Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective Based on performance assessment indicators for tertiary public hospitals,a retrospec-tive analysis was carried out on the surgical medical quality and operational efficiency of a specific tertiary A-level public hospital for the first quarter of 2024.The analysis yielded recommendations for the advancement of hospital sur-gical departments.Methods The comprehensive evaluation of the surgical performance level of a certain tertiary A-level public hospital was conducted using the weighted TOPSIS method,the rank sum ratio(RSR)method,and a fuzzy combination of the two methods.Results For the first quarter of 2024,A12,A13,and A6 were ranked in the top three by the complete review,while A3,A22,and A1 were listed in the bottom three.The majority of depart-ments fell into the middle.The evaluation's findings mainly matched the hospital departments'real state of develop-ment,showing variations in each department's performance.Conclusion The overall performance level of the surgical department in the tertiary public general hospital needs improvement.The results of surgical performance are signifi-cantly impacted by"functional positioning".In order to raise performance levels,technical innovation and efficiency optimisation should be prioritised,along with a greater attention on different components.

Objective:To explore the risk factors of bortezomib-related peripheral neuropathy (BIPN) and the clinical and electrophysiological characteristics of patients in treatment of multiple myeloma (MM).Methods:The clinical data of 71 newly diagnosed MM patients treated with BD (bortezomib + dexamethasone) regimen in Yancheng First People's Hospital from March 2016 to December 2019 were retrospectively analyzed. The bone marrow morphology, immunology, cytogenetics, molecular biology (MICM), routine electrophysiological examination before and after treatment were performed. All patients were divided into the peripheral neuropathy (PN) group and the non-PN group according to the presence or not of BIPN, and the clinicopathological differences of both groups were also compared; a binary logistic regression model was used to analyze the factors affecting the occurrence of PN. The electrophysiological characteristics were summarized and fluorescence in situ hybridization (FISH) was used to detect karyotype of BIPN patients.Results:Among 71 MM patients, there were 40 cases (56.3%) of PN and 31 cases (43.7%) of non-PN. The proportion of patients at international staging system (ISS) staging Ⅲ, and the levels of IgA, IgG, IgM, serum creatinine, β 2-microglobulin (β 2-MG) in the PN group were higher than those in the non-PN group, and hemoglobin (Hb) level in the PN group was lower than that in the non-PN group, and the differences were statistically significant (both P < 0.05). Binary logistic regression analysis showed that increased IgA ( OR = 1.151, 95% CI 1.012-1.309, P = 0.033), increased IgG ( OR = 1.055, 95% CI 1.000~1.112, P = 0.049), increased IgM ( OR = 1.010, 95% CI 1.001-1.018, P = 0.022), increased serum creatinine ( OR = 1.037, 95% CI 1.011~1.065, P = 0.005), increased β 2-MG ( OR = 1.564, 95% CI 1.039-2.354, P = 0.032) were risk factors for BIPN. Among 40 patients with BIPN, 33 cases (82.5%) of sensory nerve conduction velocity (SCV) were abnormal, 23 cases (57.5%) of motor nerve conduction velocity (MCV) were abnormal; 31 cases (77.5%) showed demyelination damage, 9 cases (22.5%) had axonal damage. Among 40 patients with BIPN, 24 cases underwent FISH detection, including 19 cases (79.2%) with chromosomal mutations, of which 12 cases (50.0%) were mixed subtype abnormal. Conclusions:MM patients with high levels of β 2-MG, IgA, IgG, IgM and serum creatinine are more prone to PN when treated with bortezomib. The electrophysiology of patients with BIPN is mainly characterized by demyelination of sensory nerves.

Objective:To investigate the expression of Toll-like receptor 8 (TLR8) in diffuse large B-cell lymphoma (DLBCL) and its correlation with clinicopathological characteristics and prognosis of patients.Methods:The data in the Oncomine database was used to analyze the difference of TLR8 mRNA expression between DLBCL tumor tissues and normal lymphocytes, and the result was verified in two independent subsets GSE 25638 and GSE 32018 of the NCBI-GEO database. The OSDLBCL online survival analysis tool was used to analyze the correlation of TLR8 mRNA relative expression level with overall survival (OS) and progression-free survival (PFS) of DLBCL patients. Gene ontology bioprocess (GO_BP) enrichment analysis was performed by using GSEA software. The correlation of TLR8 mRNA expression with tumor immune cell infiltration degree and immune checkpoint-related molecule expression was analyzed by TIMER online tool website. A total of 53 DLBCL patients who underwent lymph node biopsy in Yancheng No. 1 People's Hospital from June 2020 to June 2021 were selected. Immunohistochemistry was used to detect the expression of TLR8 protein, and its relationship with the clinicopathological characteristics of patients was analyzed.Results:The analysis result of data from Oncomine and GEO databases showed that the relative expression levels of TLR8 mRNA in tumor tissues of patients with DLBCL or activated B cell-like DLCBL were higher than those in normal lymphocytes (all P < 0.001). The results of OSDLBCL online survival analysis indicated that the OS ( P = 0.020) and PFS ( P = 0.004) in DLBCL patients with high TLR8 mRNA expression were worse than those in patients with low TLR8 mRNA expression. The level of TLR8 was related to the abnormal function of immune response, cytokine metabolism and DNA damage monitoring; the result of TIMER online analysis showed that the expression level of TLR8 mRNA was positively related to the degree of neutrophil infiltration ( r = 0.78, P < 0.001) and the expression of immunosuppressive molecules [HAVCR2 ( r = 0.85, P < 0.001), LAG3 ( r = 0.63, P < 0.001), CD274 ( r = 0.77, P < 0.001), TIGIT ( r = 0.32, P = 0.037), and C10ORF54 ( r = 0.34, P = 0.029)]. Among 53 DLBCL patients, 29 patients (54.7%) had low expression of TLR8 protein and 24 patients (45.3%) had high expression of TLR8 protein. There were statistical differences in the expressions of TLR8 protein in DLBCL patients with different serum lactate dehydrogenase and β 2-microglobulin levels (both P < 0.05). Conclusions:TLR8 is highly expressed in DLBCL patients, and TLR8 may be a prognostic marker of DLBCL.