Objective To investigate the current status of rumination and professional grief among hospice nurses,and to explore the mediating effect of death attitude between the two.Methods A total of 323 nurses in hospitals with hospice services and hospice wards in Hangzhou City were surveyed from April to July 2024 by convenience sampling method.They were investigated with general information questionnaire,Event Related Rumination Inventory,Death Attitude Profile-Revised,and Grief State Scale for Nurses by convenience sampling method.The structural equation model was used to analyze the mediating effect of death attitude between rumination and professional grief among hospice nurses.Results A total of 331 questionnaires were collected,among which 8 invalid questionnaires were deleted,and 323 valid questionnaires were retrieved,with the valid questionnaire recovery rate of 97.58％.The score of intrusive rumination dimension for hospice nurses was 13.34(7.00,20.00),and the score of deliberate rumination dimension was 16.92(11.00,24.00).The negative attitude towards death scored 38.35(29.00,48.00),while the positive attitude towards death scored 62.88(49.00,78.00).The total score of Grief State Scale for Nurses was 47.05(40.00,53.00).Hospice nurses'intrusive rumination was positively correlated with negative attitudes toward death,professional grief,and negatively correlated with positive attitudes toward death(all P＜0.05);deliberate rumination was negatively correlated with negative attitudes toward death,professional grief,and positively correlated with positive attitudes toward death(all P＜0.05).Negative death attitudes and positive death attitudes partially mediated between intrusive rumination and professional grief,with mediation effects of 0.053 and 0.037,accounting for 12.70％and 9.25％of the total effect.Negative death attitudes and positive death attitudes similarly partially mediated between deliberate rumination and professional grief,with mediation effects of-0.033 and-0.080,accounting for 10.03％and 21.33％of the total effect.Conclusion Death attitudes are a mediating variable between hospice nurses'rumination and professional grief.Nursing managers can take effective measures to improve hospice nurses'ruminative contemplation ability and positively guide positive attitudes toward death,thereby reducing their professional grief levels.

Objective To investigate the current status of rumination and professional grief among hospice nurses,and to explore the mediating effect of death attitude between the two.Methods A total of 323 nurses in hospitals with hospice services and hospice wards in Hangzhou City were surveyed from April to July 2024 by convenience sampling method.They were investigated with general information questionnaire,Event Related Rumination Inventory,Death Attitude Profile-Revised,and Grief State Scale for Nurses by convenience sampling method.The structural equation model was used to analyze the mediating effect of death attitude between rumination and professional grief among hospice nurses.Results A total of 331 questionnaires were collected,among which 8 invalid questionnaires were deleted,and 323 valid questionnaires were retrieved,with the valid questionnaire recovery rate of 97.58％.The score of intrusive rumination dimension for hospice nurses was 13.34(7.00,20.00),and the score of deliberate rumination dimension was 16.92(11.00,24.00).The negative attitude towards death scored 38.35(29.00,48.00),while the positive attitude towards death scored 62.88(49.00,78.00).The total score of Grief State Scale for Nurses was 47.05(40.00,53.00).Hospice nurses'intrusive rumination was positively correlated with negative attitudes toward death,professional grief,and negatively correlated with positive attitudes toward death(all P＜0.05);deliberate rumination was negatively correlated with negative attitudes toward death,professional grief,and positively correlated with positive attitudes toward death(all P＜0.05).Negative death attitudes and positive death attitudes partially mediated between intrusive rumination and professional grief,with mediation effects of 0.053 and 0.037,accounting for 12.70％and 9.25％of the total effect.Negative death attitudes and positive death attitudes similarly partially mediated between deliberate rumination and professional grief,with mediation effects of-0.033 and-0.080,accounting for 10.03％and 21.33％of the total effect.Conclusion Death attitudes are a mediating variable between hospice nurses'rumination and professional grief.Nursing managers can take effective measures to improve hospice nurses'ruminative contemplation ability and positively guide positive attitudes toward death,thereby reducing their professional grief levels.

This article introduces the concept analysis and theoretical basis of family caregiver benefit finding, reviews intervention research on benefit finding of family caregivers in children with autism spectrum disorder, including writing emotional expression, caregiver skill training, peer support intervention, Mind the Gap, acceptance and commitment therapy, parent-child cooperative music therapy, mindfulness yoga intervention, and Satir model intervention. This article also proposes thoughts and prospects for conducting interventions on benefit finding of family caregivers in children with autism spectrum disorder in China.

Oral medicine and deep brain stimulation are two main treatments for Parkinson′s disease (PD). But their long-term efficacies are decreasing, which limit the choice of patients in advanced stage. As a special way of sensory intervention, rhythmic cueing can improve gait parameters, reduce freezing of gait severity and improve gait-related mobility by activating the motor pathway directly, repairing internal clock, promoting internal dopamine release and improving cognitive function to maintain gait stability. Rhythmic auditory and visual cueing has a potential in PD treatment.

Clinical scales and external devices are two important ways to quantify the severity of motor symptoms for Parkinson′s disease (PD). As one representative of scales, the Unified Parkinson′s Disease Rating Scale is considered the "gold standard" in the comprehensive assessment of PD. External devices are divided into electrophysiological and mechanical devices based on the type of sensors. Both sides can monitor the PD motor symptoms objectively. Currently, numerous and ununified parameters of devices make the clinical quantification of PD symptoms still rely on scales. This article reviewed the progress on quantitative assessments of motor symptoms for Parkinson′s disease.

Maple syrup disease (MSUD) is a rare autosomal recessive disorder caused primarily by mutations of branched-chain keto acid dehydrogenase complex (BCKDC). BCKDC includes at least four pathogenic genes of BCKDHA, BCKDHB, DLD and DBT. The clinical manifestations of MSUD are complex, and the main symptoms at the early stage include difficulty in feeding, drowsiness, change in muscle tone and special urine flavor of maple syrup. As the disease progresses, convulsion, hypoglycemia, coma and systemic failure may occur. MSUD is easily missed or misdiagnosed during the neonatal period. This paper provides a review for recent progress made in research on MSUD including etiology, physiopathology, clinical manifestation, auxiliary examination and treatment, with a particular emphasis on genetic testing and treatment.
3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) ; genetics ; Humans ; Maple Syrup Urine Disease ; diagnosis ; genetics ; therapy ; Mutation

Reviewing the current research status of quaLity of Life assessment tooLs in coronary heart disease in China, this paper summarizes 14 evaLuation tooLs, incLuding 5 foreign universaL scaLes, 8 specific scaLes, and 1 domestic specific scaLe. The most commonLy used tooLs are the Concise HeaLth Status ScaLe (SF-36), the SeattLe Angina ScaLe (SAQ), and the Chinese CardiovascuLar Patient QuaLity of Life Assessment Questionnaire. In generaL, the number of studies on the quaLity of Life of patients with coronary heart disease has graduaLLy increased in recent years. The scaLe of quaLity of Life in coronary heart disease abroad is reLativeLy mature and wideLy used, and the deveLopment of scaLes in this fieLd started Late,hence the current study focused on the use of scaLes introduced abroad.

OBJECTIVETo detect potential mutations of chloride channel l (CLCN1) gene in a family affected with myotonia congenita.

METHODSClinical data of the proband and her parents and brother was collected. The coding regions of the CLCN1 gene were subjected to PCR and Sanger sequencing.

RESULTSTwo missense mutations (c.937G>A and c.1205C>T), which were respectively located within exons 8 and 11 of the CLCN1 gene, were identified in the proband. The mother and father of the proband were found to harbor the c.937G>A and c.1205C>T mutation, respectively, whilst neither mutation was found in her brother.

CONCLUSIONThe novel missense CLCN1 mutations probably underlie the disease in this family. These have enriched the spectrum of CLCN1 mutations and may facilitate further research on this disorder.

Multimedia is a widely-used teaching means in contemporary medical education.Establishing and improving the multimedia teaching material library is a strong guarantee for the smooth implementation of multimedia.The causes,significance and methods for establishment of pediatric surgery teaching multimedia material library according to the characteristics of pediatric surgery teaching are described in this article,with a view to provide a reference to other relevant professional institutions.

Many pediatric surgeons have little training in laparoscopic application.The major problem in clinical practice of laparoscopic technician is without regularly training,unsuitable indication,and ignoring peroperation management.so that there are much more serious complications.For these reasons,it is a prerequisite that surgon and anesthetist must be trained before clinical practice,and the qualification of admission should be strictly controlled.