Objective To explore the efficacy of imipenem cilastatin injection in patients with pulmonary bacterial infection and its effect on serum procalcitonin(PCT)and CD64.Methods A total of 94 patients with pulmonary bacterial infection who were diagnosed and treated in Puer People's Hospital of Yunnan from January 2021 to December 2022 were selected as research objects.The patients were randomly divided into control group and study group(n=47)by random number table method.The control group received cefoperazone-sulbactam sodium,and the study group was given imipenem cilastatin injection.Serum tumor necrosis factor-α(TNF-α),interleukin 6(IL-6),high-sensitivity C reactive protein(hs-CRP),PCT,CD64,clinical efficacy,bacterial clearance and adverse reactions were compared between the two groups.Results TNF-α,IL-6,hs-CRP,PCT and CD64 were decreased after treatment in both groups(P＜0.05),and these indexes in the study group were significantly lower than those in the control group(P＜0.05).The overall clinical response rate of the study group was higher than that of the control group(97.87%vs.80.85%,P＜0.05).The bacterial clearance rate in the study group was higher than that in the control group(89.36%vs.68.09%,P＜0.05).The incidence of adverse reactions in the study group was significantly lower than that in the control group(2.13%vs.14.89%,P＜0.05).Conclusion Imipenem cilastatin can effectively reduce inflammatory reaction and serum PCT and CD64,improve clinical efficacy and bacterial clearance rate,and reduce adverse reactions in patients with pulmonary bacterial infection.

Objectives To investigate the clinical, pathological and endoscopic characteristics of colorectal polyps treated by endoscopic mucosal resection (EMR), then evaluate its therapeutic effect and security, and analyze its significance in diagnosis and treatment. Methods Clinical and pathological data of 437 patients (687 lesions), who underwent EMR from August, 2014 to August, 2015 were collected. A retrospective analysis was made, and lesions were statistically analyzed by variables such as age, sex, endoscopic features and clinical and pathological characteristics, and so on, according to the group procedure of adenoma cancerization and 'high risk adenomas - low risk adenomas - non-adenoma polyps' to observe the curative effect and safety on EMR. Results 48.28% of the patients who received colonoscopy examines were detected with polyps, and 34.90% of them were operated EMR, including advanced adenomas, which were 17.08% of the total quantity. From non-adenoma to advanced adenoma, with a increasing possibility of carcinogenesis, the location of polyps are transferred from proximal colon to distal colon and lesions are readily to be pedunculated ones with a higher level of mucosal lobulation and other kinds of mucosal changing. The degeneration of the colorectum is associated with pedunculated polyps, distal colorectal polyps, the size (>1.0 cm), adenomas containing villous structures and mucosal lobulation. As for EMR treatment, the en bloc resection rate can reach as high as 99.70%, with a complication rate of 1.14%. Conclusions Some special characteristics can be found in the site and the endoscopic feature of advanced adenomas and degenerated adenomas. To polyps sizing in 0.5 ~ 3.0 cm, EMR with endoclips has a remarkable effect and a low complication incidence. It can reduce the process of colorectal adenoma degenerates to multiple colorectal adenocarcinoma, which can be regarded as an effective method to prevent and cure the colorectal carcinoma.