Hypertension is a serious disease that endangers human health. Although the clinical efficiency of anti-hypertensive drugs have achieved good results, there are still many different types of resistant hypertension such as drug tolerance, and the incidence of complications of hypertension such as heart failure and stroke is still high. Therefore, the development and application of non-pharmacological treatment strategies have become an important aspect of the treatment of hypertension. The sympathetic nervous system plays a key role in the pathogenesis of hypertension. At present, most non-pharmacological treatment technologies for the prevention and treatment of hypertension mainly target the sympathetic nerve function. These technologies mainly include deep brain stimulation and renal denervation. Central iliac arteriovenous anastomosis, baroreflex activation therapy, endovascular baroreflex amplification, carotid body ablation, etc. This review focuses on the application status and related advantages and disadvantages of the above-mentioned non-pharmacological treatment methods based on the sympathetic nervous system, and provides new ideas and multiple options for treatment of hypertension.