Misophonia is a psychophysiological and behavioral disorder characterized by an individual's low tolerance to specific sounds， leading to intense negative emotional experiences and physiological responses. Currently， there is no standardized and universally effective treatment for misophonia in clinical practice worldwide. This article reports the case of an 18-year-old male patient with misophonia who showed poor response to sertraline combined with exposure and response prevention therapy. Subsequently， the patient received 8 weeks of Morita therapy （once a week， 50 minutes per session）， with symptomatic improvement. By presenting this case， we explore the potential efficacy of Morita therapy in treating misophonia， aiming to provide a reference for its clinical management. ［Funded by Scientific Research Development Fund Project of Shandong Second Medical University （number， 2024FYM034）］

This article compares the diagnostic criteria for Obsessive-Compulsive Disorder (OCD) in the Diagnostic and Statistical Manual of Mental Disorders-5 th edition (DSM-5) and the International Classification of Diseases-11 th edition (ICD-11), and systematically analyzes the issues in the conceptualization and symptom classification of OCD in China, combining the Chinese Classification and Diagnostic Criteria of Mental Disorders-3 rd edition (CCMD-3), domestic psychiatry textbooks, and the Chinese Guidelines for the Prevention and Treatment of OCD. The main issues identified include imprecise concept translation, inadequate logical structure in symptom classification, inappropriate terminology, and insufficient functional understanding of "obsession and compulsion". Based on these issues, new perspectives are proposed regarding the concepts and symptom classification of OCD in China. The aim of this article is to provide suggestions for optimizing the domestic theoretical framework of OCD and to promote academic exchange and development in the field of OCD diagnosis and treatment.

General anesthesia, pivotal for surgical procedures, requires precise depth monitoring to mitigate risks ranging from intraoperative awareness to postoperative cognitive impairments. Traditional assessment methods, relying on physiological indicators or behavioral responses, fall short of accurately capturing the nuanced states of unconsciousness. This study introduces a machine learning-based approach to decode anesthesia depth, leveraging EEG data across different anesthesia states induced by propofol and esketamine in rats. Our findings demonstrate the model's robust predictive accuracy, underscored by a novel intra-subject dataset partitioning and a 5-fold cross-validation method. The research diverges from conventional monitoring by utilizing anesthetic infusion rates as objective indicators of anesthesia states, highlighting distinct EEG patterns and enhancing prediction accuracy. Moreover, the model's ability to generalize across individuals suggests its potential for broad clinical application, distinguishing between anesthetic agents and their depths. Despite relying on rat EEG data, which poses questions about real-world applicability, our approach marks a significant advance in anesthesia monitoring.
Animals ; Machine Learning ; Electroencephalography/methods* ; Ketamine/administration & dosage* ; Rats ; Male ; Propofol/administration & dosage* ; Rats, Sprague-Dawley ; Anesthesia, General/methods* ; Brain/physiology* ; Intraoperative Neurophysiological Monitoring/methods*

Objective To analyze the current status of medical services in secondary and tertiary hospitals in Shandong Province based on DRG,and to provide effective support for the implementation strategies of bidirectional referral.Methods The DRG group was used to analyze 42.348 3 million cases from 75 secondary hospitals and 69 tertiary hospitals in Shandong Province from 2019 to 2023.Experts were organized to establish standards for bidirectional referral of diseases.Results(1)35 high-frequency DRG disease groups with diagnosis,treatment ability and medical resources in secondary hospitals were selected,(2)The medical expenses and medical quality in the high-frequency DRG disease groups within secondary hospitals were lower than those in tertiary hospitals,(3)To develop standardized referral standards and programs with esophageal cancer as an example.Conclusion It is urgent to triage patients gradually and accurately through disease classification management,and formulate disease diagnosis and treatment plans and bidirectional referral standards to improve the medical quality of secondary hospitals.

Objective To analyze the current status of medical services in secondary and tertiary hospitals in Shandong Province based on DRG,and to provide effective support for the implementation strategies of bidirectional referral.Methods The DRG group was used to analyze 42.348 3 million cases from 75 secondary hospitals and 69 tertiary hospitals in Shandong Province from 2019 to 2023.Experts were organized to establish standards for bidirectional referral of diseases.Results(1)35 high-frequency DRG disease groups with diagnosis,treatment ability and medical resources in secondary hospitals were selected,(2)The medical expenses and medical quality in the high-frequency DRG disease groups within secondary hospitals were lower than those in tertiary hospitals,(3)To develop standardized referral standards and programs with esophageal cancer as an example.Conclusion It is urgent to triage patients gradually and accurately through disease classification management,and formulate disease diagnosis and treatment plans and bidirectional referral standards to improve the medical quality of secondary hospitals.

This article compares the diagnostic criteria for Obsessive-Compulsive Disorder (OCD) in the Diagnostic and Statistical Manual of Mental Disorders-5 th edition (DSM-5) and the International Classification of Diseases-11 th edition (ICD-11), and systematically analyzes the issues in the conceptualization and symptom classification of OCD in China, combining the Chinese Classification and Diagnostic Criteria of Mental Disorders-3 rd edition (CCMD-3), domestic psychiatry textbooks, and the Chinese Guidelines for the Prevention and Treatment of OCD. The main issues identified include imprecise concept translation, inadequate logical structure in symptom classification, inappropriate terminology, and insufficient functional understanding of "obsession and compulsion". Based on these issues, new perspectives are proposed regarding the concepts and symptom classification of OCD in China. The aim of this article is to provide suggestions for optimizing the domestic theoretical framework of OCD and to promote academic exchange and development in the field of OCD diagnosis and treatment.

Objective To discuss the pathogenesis of postmenopausal osteoporosis,and to validate molecular docking and predict the composition of traditional Chinese medicine based on reverse network pharmacological.Methods The shared targets of"osteoporosis"and"postmenopausal"were extracted and demonstrated by using Venn diagram.The common targets were analyzed for gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment.The protein-protein interaction(PPI)network was constructed to clarify the pathogenesis,pathways and key targets of postmenopausal osteoporosis,and finally the key target-active ingredient-traditional Chinese medicine network was constructed,and the characteristics,taste and tropism of traditional Chinese medicines with high identification values were sorted out.Results For postmenopausal osteoporosis,17 key targets of which degree value ≥ 10 that could match with traditional Chinese medicines were analysis in traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),and the results of 18 times of molecular docking tests were stable and good which performed on the highest degree value 3 targets with 6 traditional Chinese medicines components(degree value≥5,oral bioavailability≥30％,drug likeness≥0.18).Collected 52 kinds of traditional Chinese medicines(degree value ≥4)were mainly cold and bitter,belonging to liver and lung channels in channel tropism,promoting blood circulation and removing blood stasis in efficacy from 300 kinds of traditional Chinese medicines.Conclusion In this study,the targets,pathways,compositions and prescriptions were predicted for postmenopausal osteoporosis based on reverse network pharmacological and molecular docking.However,the thinking be broadening for the formulation of traditional Chinese medicine which appropriately added bitter cold drugs、drugs entering liver and lung channels,blood-activating and blood-stasis removing drugs and high-value Chinese medicines such as Ginkgo biloba,Cuscuta,Cauleratholoba,Licorice and Astragalus to improve joint inflammation,inhibit osteoclast differentiation,promote osteoblast differentiation and prevent osteoporosis for the treatment of postmenopausal osteoporosis.

Misophonia is a complex multifactorial psychophysiological and behavioral disorder, characterized by abnormally intense emotional and physiological responses to specific sounds, such as chewing, coughing, and tapping noises. Misophonia has a high prevalence rate, causes intense suffering in patients and severely impairs social functioning. There is no consensus on the classification and diagnostic criteria for misophonia. This review summarizes the clinical characteristics, epidemiology, pathogenesis, diagnosis, and treatments to provide references for further clinical research.

Misophonia is a complex multifactorial psychophysiological and behavioral disorder, characterized by abnormally intense emotional and physiological responses to specific sounds, such as chewing, coughing, and tapping noises. Misophonia has a high prevalence rate, causes intense suffering in patients and severely impairs social functioning. There is no consensus on the classification and diagnostic criteria for misophonia. This review summarizes the clinical characteristics, epidemiology, pathogenesis, diagnosis, and treatments to provide references for further clinical research.

AIM:To explore the promoting action of chloroquine on the anti-proliferation effect of dexametha-sone on acute lymphoblastic leukemia cells .METHODS:CCK-8 assay was used to assess the viability of the dexametha-sone-resistant human acute lymphoblastic leukemia CEM-C1 cell line treated with the combination of chloroquine and dexa-methasone .Western blotting , quantitative real-time PCR and LysoTracker Red staining were utilized to examine the mecha-nism.RESULTS:Combination of chloroquine and dexamethasone significantly inhibited the proliferation of CEM -C1 cells compared with control group (P<0.01).The combination of chloroquine and dexamethasone increased the abundance of glucocorticoid receptor and inhibited lysosomal function , while lysosomal inhibitor bafilomycin A 1 also increased glucocorti-coid signaling .CONCLUSION:Dexamethasone combined with chloroquine triggers an anti-proliferation effect on CEM-C1 cells via a lysosome-mediated pathway .