Salvia miltiorrhiza (S. miltiorrhiza) represents a crucial component of traditional Chinese medicine, demonstrating effects on blood circulation activation and stasis removal, and has been widely utilized in asthma treatment. This study isolated a novel phenolic acid (S1) from S. miltiorrhiza and investigated its anti-asthmatic activity and underlying mechanisms for the first time. An allergic asthma (AA) model was established using ovalbumin (OVA). The mechanism of S1's effects on AA was investigated using multi-factor joint analysis, flow cytometry, and co-culture systems to facilitate clinical asthma treatment. S1 (10 or 20 mg·kg^-1) was administered daily to mice with OVA-induced AA (OVA-AA) during days 21-25. The study examined airway responsiveness, lung damage, inflammation, and levels of immunoglobulin E (IgE), PGD2, interleukins (IL-4, 5, 10, 13, 17A), tumor necrosis factor α (TNF-α), GM-CSF, CXCL1, CCL11, and mMCP-1. Additionally, mast cell (MC) activation and degranulation were explored, along with T helper type 17 (Th17)/Treg immune cells and TLR4 pathway biomarkers. The antagonistic activity of that specific antagonist of TLR4 (TAK-242) (1 µmol·L^-1), a specific TLR4 blocker, against S1 (10 µmol·L^-1) was examined in co-cultured 16HBE cells and bone marrow-derived cells (BMDCs) or splenic lymphocytes (SLs) induced with LPS (1 µg·mL^-1) to elucidate the TLR4 pathway's mediating role. S1 demonstrated reduced airway responsiveness, lung damage, and inflammation, with downregulation of IgE, PGD2, interleukins, TNF-α, GM-CSF, CXCL1, CCL11, and mMCP-1. It also impeded MC activation and degranulation, upregulated IL-10, and influenced Th17/Treg immune cell transformation following OVA challenge. Furthermore, S1 inhibited the TLR4 pathway in OVA-AA mice, and TLR4 antagonism enhanced S1's positive effects. Analysis using an OVA-AA mouse model demonstrated that S1 alleviates AA clinical symptoms, restores lung function, and inhibits airway response. S1's therapeutic effects occur through regulation of Th17/Treg immune cells and inflammation, attributable at least partially to the TLR4 pathway. This study provides molecular justification for S1 in AA treatment.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To explore quality evaluation system for standardized training of general residents based on the six core competencies of World Organization of Family Doctors(WONCA).Methods The literatures meeting the requirements were selected by literature screening method under the framework of WONCA's six core competencies.The qualitative data were collected in the form of open questionnaires,and the indicator system was determined after two rounds of consultation.The evaluation indexes for residents training quality were selected by Colaizzi 7-step analysis method based on phenomenology.The weights of all indexes were calculated by analytic hierarchy process(AHP)to formulate quality evaluation system.Results 33 indexes in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.)were determined to construct quality evaluation system for standardized training of general residents.The weights of all indexes were determined by AHP.In all the indexes,weights of trainees'income(0.082),superiors attention(0.081)and the total completion assessment(0.113)were the highest.Conclusion The research results show that in the evaluation of quality system for standardized training of general residents,it is necessary to pay close attentions to the indexes with the highest weights in the 10 dimensions(information about residents,understanding about training content,basic information about the training hospital,et al.),especially for trainees'income,superiors attention and the total completion assessment to improve the evaluation system.

Objective To compare the changes of brain voxel-mirrored homotopic connectivity(VMHC)of patients before and after Tai Chi Chuan training based on functional magnetic resonance imaging(fMRI)technology;To discuss the central effect mechanism of Tai Chi Chuan in treating chronic fatigue syndrome(CFS).Methods A total of 25 CFS patients(experiment group)and 27 healthy individuals(control group)were recruited to undergo a 1-month Tai Chi Chuan intervention.All receive one month of Tai Chi Chuan training.Differences in SF-36 scores and VMHC between CFS patients and HCs were compared.Results Before training,the SF-36 scores in the experimental group were significantly lower than those in the control group(P<0.001),and the VMHC in the bilateral inferior occipital gyrus,paracentral lobule,lingual gyrus,insula and superior temporal gyrus brain areas were weakened.After training,the scores of SF-36 in the experimental group significantly increased(P<0.001),and the VMHC in bilateral inferior occipital gyrus,superior temporal gyrus,anterior cuneiform lobe and paracentral lobule were significantly enhanced.The difference in whole brain VMHC was positively correlated with the difference in energy scores in SF-36(r=0.456,P=0.025);some scores of SF-36 in the control group significantly increased(P<0.05),and no significant changes in VMHC were observed in brain regions.Conclusion Tai Chi Chuan can effectively improve the quality of life of patients with CFS.This change may be related to the enhancement of functional connections in brain regions such as inferior occipital gyrus,superior temporal gyrus,precuneus,paracentral lobule,et al.