Objective:To systematically evaluate qualitative researches on the real experience of adolescent cancer patients returning to school, and provide theoretical basis for formulating intervention measures to promote adolescent cancer returning to school.Methods:This study is a Meta-synthesis of qualitative researches. Using computers to search PubMed, CINAHL, Cochrane Library, Joanna Briggs Institute (JBI) Evidence-based Healthcare Center Database in Australia, Web of Science, ScienceDirect, China Biology Medicine Disc, China National Knowledge Infrastructure, Wanfang and VIP Databases for qualitative researches on the real experience of adolescent cancer patients returning to school. The search period was from the establishment of the databases to March 8, 2023. The literatures were evaluated using the qualitative research quality evaluation standards of JBI Evidence-based Healthcare Center, and the results were summarized and integrated using a collection and integration method.Results:A total of 8 qualitative studies were included, similar results were classified into 12 categories, and 4 themes were integrated. The integration results included that returning to school was a complex process, the benefits of returning to school, the difficulties of returning to school and social support as important promoting factors for patients returning to school.Conclusions:Adolescent cancer patients face practical difficulties such as being isolated, distancing themselves from friends, consciously being different from others and falling behind in learning. Medical staffs need to pay attention to the mental health of patients, encourage them to return to school, and can collaborate with families and schools to build a family hospital school response plan for adolescent cancer patients returning to school.