Objective:To explore the related factors and treatment effect observation of Parkinson disease(PD) accompanied by depression.Methods:Two hundred patients with PD admitted to Baoding Zhuozhou Baoshihua Hospital from March 2016 to March 2020 were selected. According the scores of Hamilton depression inventory 24-item version (HAMD-24), they were divided into the case group (PD accompanied by depression, HAMD-24≥8 scores, 98 cases) and the control group (PD without depression, HAMD-24<8 scores,102 cases). Single factor analysis and multivariate regression analysis were used to analyze the influencing factors of PD accompanied by depression. The patients in the case group were divided into psychological treatment group and non-psychological treatment group by random number table method, each group with 49 cases. The differences in depression degree, quality of life and sleep quality before and after treatment between the two groups were compared.Results:The incidence rate of PD accompanied by depression was 49.0% (98/200). The multivariate regression analysis showed that the Hoehn-Yahr classification (H-Y classification), Pittsburgh Sleep Quality Index (PSQI) scores and abnormal marital status were the influence factors of PD accompanied by depression ( P<0.05); the education years was the protective factor of PD accompanied by depression ( P<0.05). After treatment, the scores of HAMD-24 and PSQI in the psychological treatment group and the non-psychological treatment group were decreased, and the scores of HAMD-24 and PSQI in the psychological treatment group were lower than those in the non-psychological treatment group: (11.78 ± 2.94) scores vs. (15.55 ± 3.91) scores, (5.18 ± 1.05) scores vs. (5.74 ± 1.12) scores, the differences were statistically significant ( P<0.05). After treatment, the improved degree of scores of five item of HAMD-24 in the psychological treatment group were higher than those in the non-psychological treatment group, the differences were statistically significant ( P<0.05). Conclusions:PD accompanied by depression is affected by multiple factors. Strengthening psychological treatment can reduce the degree of depression in patients with PD accompanied by depression and improve the quality of sleep and life.

Objective To discuss the clinical characteristics of hepatic perivascularepithelioid cell tumor (PEComa). Methods Clinical data of one patient with hepatic PEComa in the Second Affiliated Hospital, Zhejiang University School of Medicine in 2011 were analyzed retrospectively. The informed consent of the patient was obtained and the ethical committee approval was received. The patient was a 25-year-old female and was admitted in hospital for the physical examination finding of space occupying lesions in the liver. The results of physical and laboratory examinations were normal. Multiple round-like mass of low density with poorly defined borders were observed in the liver by CT scan. Significant enhancement was observed in the arterial phase by enhancement scan, and homo- or hypo-enhancement in the delayed phase. The liver lesions showed intermediated signal intensity on T1WI by MRI and slightly hyperintense on T2WI. Significant enhancement was observed in the arterial phase after enhancement and degraded in the delayed phase. The patient was primarily diagnosed with liver focal nodular hyperplasia clinically. Results After sufficient preoperative preparation, hepatectomy was performed on the patient under general anesthesia by tracheal intubation on December 8th , 2011. The tumor was observed
composed of polygonal morphology cells of epithelial cells without lipocytes or abnormal blood vessels by pathological examination. The tumor was observed with strongly positive human melanoma black-45 (HMB-45), smooth muscle actin (SMA), and positive vimentin, cluster of differentiation (CD) 34. The diagnosis of hepatic PEComa was confirmed pathologically. The patient recovered well and was discharged from hospital 1 week after operation. No recurrence or metastasis was observed during the regular follow-up till the submission date. Conclusions Hepatic PEComa is extremely rare without specific clinical manifestation. The diagnosis depends on the pathological examination. Surgical resection is an effective method for the tumor with a good prognosis.