Mitochondria play a crucial role as organelles, managing several physiological processes such as redox balance, cell metabolism, and energy synthesis. Initially, the assumption was that mitochondria primarily resided in the host cells and could exclusively transmit from oocytes to offspring by a mechanism known as vertical inheritance of mitochondria. Recent scholarly works, however, suggest that certain cell types transmit their mitochondria to other developmental cell types via a mechanism referred to as intercellular or horizontal mitochondrial transfer. This review details the process of which mitochondria are transferred across cells and explains the impact of mitochondrial transfer between cells on the efficacy and functionality of cancer cells in various cancer forms. Specifically, we review the role of mitochondria transfer in regulating cellular metabolism restoration, excess reactive oxygen species (ROS) generation, proliferation, invasion, metastasis, mitophagy activation, mitochondrial DNA (mtDNA) inheritance, immune system modulation and therapeutic resistance in cancer. Additionally, we highlight the possibility of using intercellular mitochondria transfer as a therapeutic approach to treat cancer and enhance the efficacy of cancer treatments.

Objective To investigate the correlation between serum remnant cholesterol(RC)levels and the occurrence of arteriosclerosis obliterans(ASO)of the lower extremity in patients with type 2 diabetes mellitus(T2DM).Methods 355 cases of T2DM patients hospitalized in the department of endocrinology of Tianjin Hospital affiliated with Tianjin University from January 2018 to December 2022 were selected and di-vided into the non-ASO group(180 cases)and the ASO group(175 cases)according to whether the patients were combined with ASO or not.General clinical and laboratory data of patients were collected and RC levels were calculated;Spearman rank correlation analysis was performed to evaluate the correlation between RC lev-els and metabolic indices,and multivariate logistic regression analysis was conducted to assess the association between serum RC levels and the risk of ASO in T2DM patients.Results Compared with the non-ASO group,the ASO group had older age,the course of diabetes was longer,the incidence rates of diabetic peripher-al neuropathy,diabetic nephropathy,coronary heart disease,hypertension,and cerebral infarction were higher,statin use was more frequent,the levels of systolic blood pressure(SBP),triglyceride(TG),creatinine(Cr),uric acid(UA),and RC were higher,and the level of high-density lipoprotein cholesterol(HDL-C)was lower,all differences were statistically significant(P＜0.05).Spearman rank correlation analysis showed that serum RC levels were positively correlated with TG,total cholesterol(TC),and UA(r=0.628,0.289,0.192,P＜0.001),and negatively correlated with HDL-C(r=-0.202,P＜0.001).Multivariate logistic regression anal-ysis revealed that age(OR=1.095,95％CI:1.066-1.124,P＜0.001),diabetic peripheral neuropathy(OR=1.877,95％CI:1.114-3.162,P=0.018),diabetic nephropathy(OR=2.149,95％CI:1.272-3.629,P=0.004),systolic blood pressure(OR=1.017,95％CI:1.004-1.031,P=0.012),and RC(OR=2.644,95％CI:1.569-4.453,P＜0.001)were independent influencing factors for ASO in T2DM patients.Conclusion Elevated serum RC levels are closely associated with ASO in T2DM patients.

A 53-year woman and her 18-year daughter presenting with bone pain, bone fractures, bone deformities and short stature were admitted to Gansu Provincial People′s Hospital in March 2021. Laboratory tests showed low blood phosphorus, low renal phosphorus threshold, normal or low blood calcium, and normal or increased PTH. The high-throughput sequencing indicated heterozygous mutations of the PHEX gene (Phosphate-regulating gene with Homology to Endopeptidases on the X chromosome) in two patients, which was not detected in other family members; finally the diagnosis of X-linked dominant hypophosphatemic rickets/osteomalacia(XLH)was confirmed for these two patients. Treated with neutral phosphorus solution and Rocaltrol, bone pain was relieved completely in the younger patient, but not for her mother due to long disease course and severe complications. Because of the large heterogeneity of the disease there are high missed diagnosis and misdiagnosis rates for XLH. In this paper a pedigree of XLH is reported with literature review.

Objective To investigate the therapy effect of fermented cordyceps powder on diabetic cardiomyopathy, and the effect on expressions of NLRP3, Caspase-1 and interleukin (IL)-1βin myocardium of diabetic rats. Methods A total of 45 male SD rats were randomly divided into normal control group (group CON), diabetes group (group DM) and fermented cordyceps powder administration group (group CS, 1 g · kg-1 · d-1). Diabetes rat model was induced by tail vein injection with streptozotocin (45 mg/kg) in group DM and group CS. The rats in group CS were given fermented cordyceps powder solution by gavage at a single dose of 1 g·kg-1·d-1 for 18 weeks. Rats of group CON and group DM were given 0.9%NaCl in the same way. All rats were sacrificed after 18 weeks. The pathological changes in myocardium were observed by HE staining and electron microscope. The expression of NLRP3 in myocardium was detected by Western blotting. The expression levels of NLRP3, Caspase-1 and IL-1βin myocardium were detected by immunohistochemistry. Results (1) Myocardial necrosis and fibrosis and mitochondrial damages were observed under electron microscope in group DM. The above-mentioned pathological changes were improved in the group CS. (2) The result of Western blotting showed that the expression of NLRP3 in myocardium was significantly increased in group DM and group CS than that in group CON, and the expression of NLRP3 was significantly lower in group CS than that in group DM. (3) The result of immunohistochemistry showed that, compared with the group CON, the expressions of NLRP3, Caspase-1 and IL-1β in myocardium were significantly increased in group DM and group CS, and which were significantly lower in group CS than those in group DM. Conclusion Fermented cordyceps powder can improve diabetic cardiomyopathy through decreasing the expressions of NLRP3, Caspase-1 and IL-1βin myocardium.

Objective To investigate the effect of Jinqi Jiangtang tablet on the activation of T helper type 17 (Th17) and the expressions of interleukin (IL)-17 and IL-23 in kidney of diabetic rats. Methods A total of 45 male SD rats were randomly divided into normal control group (NC, n=15) and experimental group (n=30). Diabetes was induced by tail vein injection with streptozotocin (STZ, 45 mg/kg). The well-established 28 diabetic model rats were then randomly divided into diabetes group (DM, n=14) and Jinqi Jiangtang tablet administration group (Jinqi, n=14). The rats in Jinqi group were given Jinqi Jiangtang tablet solution by gavage at a single dose of 2.1 g·kg-1·d-1 for 18 weeks, while NC group and DM group were given 0.9%NaCl in the same way. All rats were sacrificed after 18 weeks. The circulating Th17 frequencies were assessed using flow cytometry. Serum IL-17 and IL-23 levels were measured by enzyme-linked immunosorbent assay. The pathological changes in kidney were studied by electron microscope. The expressions of IL-17 and IL-23 in kidney were detected using immunohistochemistry. Results (1) Compared with the group NC, the circulating Th17 frequencies were significantly increased in group DM and group Jinqi. The circulating Th17 frequencies were significantly lower in group Jinqi than those in group DM. (2) Compared with the group NC, the serum IL-17 and IL-23 levels were significantly increased in group DM and group Jinqi. The serum IL-17 and IL-23 levels were significantly lower in group Jinqi than those in group DM. (3) In group DM, irregular thickening of glomerular basement membrane, fusion of epithelial cell foot processes and mesangial expansion were observed by electron microscope. The above-mentioned pathological changes were improved inthe group Jinqi. (4) Compared with the group NC, the expressions of IL-17 and IL-23 in the renal cortex were significantly increased in group DM and group Jinqi, and those were significantly lower in group Jinqi than those in group DM. Conclusion The activation of Th17 and the increased expressions of IL-17 and IL-23 in kidney play a potential role in diabetic nephropathy. Jinqi Jiangtang tablet can improve diabetic nephropathy through inhibiting the activating Th 17 and decreasing the expression of IL-17 and IL-23 in kidney.

In recent years,the prevalence of diabetes has increased rapidly,and which has become a serious public health problem worldwide.Diabetic nephropathy is a major cause of end-stage renal failure,which is also one of the most common chronic complication of diabetes.However,the pathogenesis of diabetes and diabetic nephropathy has not been fully elucidated up to now.IL-17 plays a key role in autoimmune disease and inflammatory disease.This article reviews the role of IL-17 in the pathogenesis of diabetes and diabetic nephropathy.