1.Association between Monocyte-to-high-density lipoprotein cholesterol Ratio and Sarcopenia
Feng CUI ; Chen MI ; Yuanhua SHE
Journal of Medical Research 2025;54(2):147-151,158
Objective To investigate the association between the monocyte-to-high-density lipoprotein cholesterol ratio(MHR)and sarcopenia in an adult population.Methods A cross-sectional study was conducted with 8085 participants aged 20 years and older,selected from four cycles(2011-2018)of the National Health and Nutrition Examination Survey(NHANES).Multivariate Logistic re-gression model was used to evaluate the association between MHR and sarcopenia.Variance inflation factors(VIF)were calculated to as-sess multicollinearity between variables.Restricted cubic splines were employed to explore nonlinear relationships,with interaction tests and subgroup analyses performed as well.Results In the fully adjusted model,MHR was positively associated with sarcopenia(OR=2.56,95％CI:1.73-3.79,P＜0.001).This association was more pronounced in participants with smoking history and cardiovascular disease.Additionally,restricted cubic spline analysis indicated a linear relationship between MHR and sarcopenia.Conclusion MHR is positively associated with the risk of sarcopenia and may serve as a potential early indicator for identifying sarcopenia.
2.Association between Monocyte-to-high-density lipoprotein cholesterol Ratio and Sarcopenia
Feng CUI ; Chen MI ; Yuanhua SHE
Journal of Medical Research 2025;54(2):147-151,158
Objective To investigate the association between the monocyte-to-high-density lipoprotein cholesterol ratio(MHR)and sarcopenia in an adult population.Methods A cross-sectional study was conducted with 8085 participants aged 20 years and older,selected from four cycles(2011-2018)of the National Health and Nutrition Examination Survey(NHANES).Multivariate Logistic re-gression model was used to evaluate the association between MHR and sarcopenia.Variance inflation factors(VIF)were calculated to as-sess multicollinearity between variables.Restricted cubic splines were employed to explore nonlinear relationships,with interaction tests and subgroup analyses performed as well.Results In the fully adjusted model,MHR was positively associated with sarcopenia(OR=2.56,95％CI:1.73-3.79,P＜0.001).This association was more pronounced in participants with smoking history and cardiovascular disease.Additionally,restricted cubic spline analysis indicated a linear relationship between MHR and sarcopenia.Conclusion MHR is positively associated with the risk of sarcopenia and may serve as a potential early indicator for identifying sarcopenia.
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