Objective To compare the clinical efficacy and safety of catheter-directed intra-arterial thrombolysis(CDT)and percutaneous mechanical thrombectomy(PMT)in treating long-segment occlusion of lower extremity artery complicated by thrombosis.Methods The clinical data of 21 patients with long-segment occlusion of lower extremity artery complicated by thrombosis,who were admitted to the Ningbo Municipal Medical Center Lihuili Hospital from January 2021 to June 2024,were retrospectively analyzed.According to the treatment methods,the patients were divided into CDT group(n=10)and PMT group(n=11).SPSS statistical software was used to analyze the patient's general data,intraoperative condition,postoperative short-term complications,average hospital stay,and used dose of urokinase.The clinical efficacy and safety of the two treatment methods were compared between the two groups.Results No statistically significant differences in the surgical success rate,perioperative bleeding,ischemia-reperfusion injury,intraoperative thrombus falling off,operation time,and hospitalization days existed between the two groups(all P＞0.05).During hospital stay the total used dose of urokinase in CDT group was obviously higher than that in PMT group(P＜0.05).Conclusion For long-segment occlusion of lower extremity artery complicated by thrombosis,both CDT and PMT are effective thrombus clearance regimen.However,in CDT treatment the total used amount of urokinase is higher,which carries certain risk for patients with abnormal coagulation function and for patients having a higher risk of bleeding,therefore,the clinicians should seriously take this point into account when making treatment decisions.