Objective To explore the characteristics and influencing factors of drug-induced liver injury(DILI)associated with the postoperative use of propacetamol,and to provide guidance for rational clinical medication.Methods A retrospective analysis was conducted on hospitalized patients who underwent surgical treatment and were administered propacetamol from January 2022 to June 2024.Cases were screened based on established inclusion and exclusion criteria.Statistical analyses were performed on patients'demographic data,medication information,liver function indicators before and after medication,comorbid conditions,and concomitant medications to assess the incidence and influencing factors of propacetamol-related DILI.A multivariate Logistic regression analysis was conducted to identify related risk factors.Results A total of 7,579 patients were sampled,of which 2,114 met the inclusion criteria.Among them,531 patients(25.1%)experienced DILI,primarily presenting with abnormal liver function indicators.This included elevated alanine aminotransferase in 379 cases(71.4%),elevated aspartate aminotransferase in 197 cases(37.1%),elevated alkaline phosphatase in 209 cases(39.4%),and elevated total bilirubin in 92 cases(17.3%).Univariate analysis revealed that there were significant differences in gender,height,age,weight,body mass index(BMI),duration of propacetamol use,total medication dosage,concomitant use of hepatic-metabolized antibiotics,and history of liver disease between the DILI group and non-DILI group(P<0.05).Multivariate Logistic regression analysis showed that patient gender,BMI,total propacetamol dosage,liver-related diseases,and concomitant use of hepatic-metabolized antibiotics as independent risk factors for DILI(P<0.05).Conclusion The use of propacetamol for postoperative analgesia presents a risk for liver injury,and the risk is particularly pronounced in males,obesity,high-dose dosing,patients with underlying hepatic disease,and comorbid hepatic metabolism of antimicrobial drug use.It is recommended to strengthen the monitoring of liver function in clinical application,strictly control the dosage and duration of treatment,and avoid co-administration with hepatotoxic drugs to ensure the safety of drug use.

Objective To explore the characteristics and influencing factors of drug-induced liver injury(DILI)associated with the postoperative use of propacetamol,and to provide guidance for rational clinical medication.Methods A retrospective analysis was conducted on hospitalized patients who underwent surgical treatment and were administered propacetamol from January 2022 to June 2024.Cases were screened based on established inclusion and exclusion criteria.Statistical analyses were performed on patients'demographic data,medication information,liver function indicators before and after medication,comorbid conditions,and concomitant medications to assess the incidence and influencing factors of propacetamol-related DILI.A multivariate Logistic regression analysis was conducted to identify related risk factors.Results A total of 7,579 patients were sampled,of which 2,114 met the inclusion criteria.Among them,531 patients(25.1%)experienced DILI,primarily presenting with abnormal liver function indicators.This included elevated alanine aminotransferase in 379 cases(71.4%),elevated aspartate aminotransferase in 197 cases(37.1%),elevated alkaline phosphatase in 209 cases(39.4%),and elevated total bilirubin in 92 cases(17.3%).Univariate analysis revealed that there were significant differences in gender,height,age,weight,body mass index(BMI),duration of propacetamol use,total medication dosage,concomitant use of hepatic-metabolized antibiotics,and history of liver disease between the DILI group and non-DILI group(P<0.05).Multivariate Logistic regression analysis showed that patient gender,BMI,total propacetamol dosage,liver-related diseases,and concomitant use of hepatic-metabolized antibiotics as independent risk factors for DILI(P<0.05).Conclusion The use of propacetamol for postoperative analgesia presents a risk for liver injury,and the risk is particularly pronounced in males,obesity,high-dose dosing,patients with underlying hepatic disease,and comorbid hepatic metabolism of antimicrobial drug use.It is recommended to strengthen the monitoring of liver function in clinical application,strictly control the dosage and duration of treatment,and avoid co-administration with hepatotoxic drugs to ensure the safety of drug use.

Objective To assess the level of knowledge and influencing factors related to osteoporosis in elderly patients with osteoporotic vertebral fractures after surgery in China,providing a basis for improving their under-standing.Methods A total of 5 955 elderly patients with osteoporotic vertebral fractures in 31 provinces(au-tonomous regions and municipalities)were selected as survey subjects from September to November 2023.A gener-al information questionnaire and an osteoporosis knowledge assessment tool were used for a cross-sectional survey.The univariate analysis and logistic regression were used to analyze the influencing factors.Results 5 248 valid questionnaires were collected,and the effective questionnaire recovery rate was 88.13％.The score of osteoporosis knowledge assessment tool of elderly patients with osteoporotic vertebral fractures after surgery was 11.00(7.00,13.00).70.03％of the patients had poor knowledge of osteoporosis.The location of the hospital(eastern re-gion hospitals),presence of tumors,past surgical history,admission for falls,diagnosis of severe osteoporosis,postop-erative complications,use of walking aids,use of anti-osteoporosis drugs,osteoporosis health education,fall prevention health education,and health education forms(video,telephone,manual,and WeChat)were the influencing factors of osteoporosis knowledge in elderly patients with osteoporotic vertebral fractures after surgery(P＜0.05).Conclusion The osteoporosis knowledge of elderly patients with osteoporotic vertebral fractures after surgery needs to be im-proved.To help the secondary prevention of osteoporosis,the standardized osteoporosis health education should be strengthened,and attention should be paid to key groups.

Objective To investigate the impact of SARS-CoV-2 infection on male semen quality through meta-analysis and retrospec-tive study.Methods Literature retrieval was conducted in PubMed,CNKI,Wanfang Database and CBM database.Meta-analysis was performed using Stata 15.0.The male patients meeting the inclusion criteria from our hospital were enrolled as study subjects.General demographic data and semen parameters were collected.Single factor analysis of variance and graphing of semen parameters were con-ducted using GraphPad Prism 9.5.1.The test level was set at 0.05.Results A total of 9 studies involving 267 patients were included in the meta-analysis.There were no significant differences in sperm concentration and survival rate before and after SARS-CoV-2 infec-tion(P＞0.05).Semen volume and percentage of normal morphology significantly increased during 1-3 months after infection(P=0.005,P=0.010),with semen volume recovering to pre-infection level＞3 months later(P＞0.05).Sperm motility and progressive mo-tility increased＞3 months after infection(P=0.046,P=0.045),recovering to pre-infection levels(P=0.099,P=0.098).Sperm DNA fragmentation index may be temporarily elevated within 3 months after infection but gradually decreased＞3 months later.In the retrospective study of 8 cases,there were no statistical differences in semen parameters at different stages compared with pre-infection(P＞0.05),but semen parameters showed a negative trend during＜1 month after infection and recovered to pre-infection levels＞3 months later.Conclusion The results of this laboratory study are basically consistent with the meta-analysis.SARS-CoV-2 infection in males only caused short-term negative effects on sperm morphology,vitality and DNA integrity,but generally recovered to pre-infection levels＞3 months after infection.Due to the limitations of study subjects and sample size,the impact of SARS-CoV-2 infection on male semen quality needs to be further confirmed by long-term large-scale prospective studies.

Objective To assess the level of knowledge and influencing factors related to osteoporosis in elderly patients with osteoporotic vertebral fractures after surgery in China,providing a basis for improving their under-standing.Methods A total of 5 955 elderly patients with osteoporotic vertebral fractures in 31 provinces(au-tonomous regions and municipalities)were selected as survey subjects from September to November 2023.A gener-al information questionnaire and an osteoporosis knowledge assessment tool were used for a cross-sectional survey.The univariate analysis and logistic regression were used to analyze the influencing factors.Results 5 248 valid questionnaires were collected,and the effective questionnaire recovery rate was 88.13％.The score of osteoporosis knowledge assessment tool of elderly patients with osteoporotic vertebral fractures after surgery was 11.00(7.00,13.00).70.03％of the patients had poor knowledge of osteoporosis.The location of the hospital(eastern re-gion hospitals),presence of tumors,past surgical history,admission for falls,diagnosis of severe osteoporosis,postop-erative complications,use of walking aids,use of anti-osteoporosis drugs,osteoporosis health education,fall prevention health education,and health education forms(video,telephone,manual,and WeChat)were the influencing factors of osteoporosis knowledge in elderly patients with osteoporotic vertebral fractures after surgery(P＜0.05).Conclusion The osteoporosis knowledge of elderly patients with osteoporotic vertebral fractures after surgery needs to be im-proved.To help the secondary prevention of osteoporosis,the standardized osteoporosis health education should be strengthened,and attention should be paid to key groups.

Objective To understand the current situation and influencing factor of information needs in nursing administrators , so as to seek the effective methods and ways to meet their needs and improve their information ability .Methods Sixty-eight nursing administrators were surveyed by the self -designed questionnaire about the demographic data , the contents, the ways and barriers of information needs and so on .Results The percent of nursing administrators who often participated in the training of management related knowledge and information retrieval were respectively 23.5% and 1.5%.The information needs in daily work is mainly the business management (38.3%) and professional knowledge and skills (36.8%).The contents of information needs in nursing administrators were mainly the nursing quality management (42.6%), final cost management (23.5%) and management psychology (22.1%).The analysis of the location of searching the information showed that the cases of nurses who searched the information in the library , department , home and internet bar were respectively 58 (85.3%),3 (4.4%),27 (39.7%),2 (2.9%).The main obstacles to search the information were respectively the poor level of computer (3,4.4%), the poor level of English (44,64.7%), the lack of time (32,47.1%) and the lack of retrieval knowledge (28,41.2%).Conclusions The information needs in nursing administrators is mainly the information of increasing the quality of nursing management , and the main factors on affecting the needs were the level of English and the knowledge of literature retrieval .The management departments should strengthen the training of nursing administrators , and the library should play its functions to meet the needs of nursing administrators .