This study compared and evaluated the color change and fracture resistance of reattached tooth fragments stored in different media after trauma. Sixty extracted permanent incisors were examined. Tap water, saline solution, milk, artificial saliva, and casein phosphopeptide-amorphous calcium and phosphate (CPP-ACP) were used as storage media. The control group used no storage media. Color changes were calculated using CIE L*a*b* values measured by a spectrophotometer at seven time points: just before reproducing the tooth fracture (T0); after drying the fractured crown for 24 hours following fracture (T1); immediately after rehydration in the storage medium for 20 minutes (T2); and 12 hours (T3), 24 hours (T4), 1 week (T5), and 3 weeks (T6) after reattaching the fractured crown. Fracture resistance was uniformly measured 3 weeks after reattachment. The results showed that the CPPACP group showed significantly more effective color recovery than the other storage media groups, with the color returning to natural levels by T2. Color recovery was observed in all groups at T6. Fracture resistance did not differ significantly between the six groups. No significant difference was observed between the storage media regarding color recovery and fracture resistance three weeks after reattachment.

This study compared and evaluated the color change and fracture resistance of reattached tooth fragments stored in different media after trauma. Sixty extracted permanent incisors were examined. Tap water, saline solution, milk, artificial saliva, and casein phosphopeptide-amorphous calcium and phosphate (CPP-ACP) were used as storage media. The control group used no storage media. Color changes were calculated using CIE L*a*b* values measured by a spectrophotometer at seven time points: just before reproducing the tooth fracture (T0); after drying the fractured crown for 24 hours following fracture (T1); immediately after rehydration in the storage medium for 20 minutes (T2); and 12 hours (T3), 24 hours (T4), 1 week (T5), and 3 weeks (T6) after reattaching the fractured crown. Fracture resistance was uniformly measured 3 weeks after reattachment. The results showed that the CPPACP group showed significantly more effective color recovery than the other storage media groups, with the color returning to natural levels by T2. Color recovery was observed in all groups at T6. Fracture resistance did not differ significantly between the six groups. No significant difference was observed between the storage media regarding color recovery and fracture resistance three weeks after reattachment.

Objective: This study aimed to evaluate the utility of the Korean version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in hospital settings and to identify items sensitive for detecting autism spectrum disorder (ASD) trait. Methods: The Q-CHAT was administered to a clinical sample of children presenting with developmental delays with a high probability of ASD in a hospital setting (n=37), as well as to typically developing community children (n=67), aged 12 to 54 months. Results: The mean Q-CHAT total score in the hospital sample (42.0±13.6) was significantly higher than in the community sample (29.9±7.8), with maximized sensitivity and adequate specificity at 32.5 (sensitivity=0.811, specificity=0.687). The internal consistency of Q-CHAT was 0.764 for the overall sample and 0.825 for the hospital sample. Q-CHAT total scores and item scores in the hospital sample remained stable across age groups, indicating age-invariant properties. The hospital sample showed higher endorsement of less favorable development in social interaction and reciprocity items compared to community sample. No difference in the Q-CHAT item scores was present among age groups in the hospital samples. In the community samples, item scores, such as comprehending a child’s speech, using the hand of others as a tool, adapting to a change in routine, repeating the same action, and making unusual finger movements, decreased with the advance of age. Conclusion The Korean version of the Q-CHAT demonstrates good validity and reliability and is effective in discriminating autistic traits even in children older than 24 months. The items endorsed for hospital samples varied from community samples, implying item-specific sensitivity for hospital samples.

Objective: This study aimed to evaluate the utility of the Korean version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in hospital settings and to identify items sensitive for detecting autism spectrum disorder (ASD) trait. Methods: The Q-CHAT was administered to a clinical sample of children presenting with developmental delays with a high probability of ASD in a hospital setting (n=37), as well as to typically developing community children (n=67), aged 12 to 54 months. Results: The mean Q-CHAT total score in the hospital sample (42.0±13.6) was significantly higher than in the community sample (29.9±7.8), with maximized sensitivity and adequate specificity at 32.5 (sensitivity=0.811, specificity=0.687). The internal consistency of Q-CHAT was 0.764 for the overall sample and 0.825 for the hospital sample. Q-CHAT total scores and item scores in the hospital sample remained stable across age groups, indicating age-invariant properties. The hospital sample showed higher endorsement of less favorable development in social interaction and reciprocity items compared to community sample. No difference in the Q-CHAT item scores was present among age groups in the hospital samples. In the community samples, item scores, such as comprehending a child’s speech, using the hand of others as a tool, adapting to a change in routine, repeating the same action, and making unusual finger movements, decreased with the advance of age. Conclusion The Korean version of the Q-CHAT demonstrates good validity and reliability and is effective in discriminating autistic traits even in children older than 24 months. The items endorsed for hospital samples varied from community samples, implying item-specific sensitivity for hospital samples.

Objective: This study aimed to evaluate the utility of the Korean version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in hospital settings and to identify items sensitive for detecting autism spectrum disorder (ASD) trait. Methods: The Q-CHAT was administered to a clinical sample of children presenting with developmental delays with a high probability of ASD in a hospital setting (n=37), as well as to typically developing community children (n=67), aged 12 to 54 months. Results: The mean Q-CHAT total score in the hospital sample (42.0±13.6) was significantly higher than in the community sample (29.9±7.8), with maximized sensitivity and adequate specificity at 32.5 (sensitivity=0.811, specificity=0.687). The internal consistency of Q-CHAT was 0.764 for the overall sample and 0.825 for the hospital sample. Q-CHAT total scores and item scores in the hospital sample remained stable across age groups, indicating age-invariant properties. The hospital sample showed higher endorsement of less favorable development in social interaction and reciprocity items compared to community sample. No difference in the Q-CHAT item scores was present among age groups in the hospital samples. In the community samples, item scores, such as comprehending a child’s speech, using the hand of others as a tool, adapting to a change in routine, repeating the same action, and making unusual finger movements, decreased with the advance of age. Conclusion The Korean version of the Q-CHAT demonstrates good validity and reliability and is effective in discriminating autistic traits even in children older than 24 months. The items endorsed for hospital samples varied from community samples, implying item-specific sensitivity for hospital samples.

Objective: This study aimed to evaluate the utility of the Korean version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in hospital settings and to identify items sensitive for detecting autism spectrum disorder (ASD) trait. Methods: The Q-CHAT was administered to a clinical sample of children presenting with developmental delays with a high probability of ASD in a hospital setting (n=37), as well as to typically developing community children (n=67), aged 12 to 54 months. Results: The mean Q-CHAT total score in the hospital sample (42.0±13.6) was significantly higher than in the community sample (29.9±7.8), with maximized sensitivity and adequate specificity at 32.5 (sensitivity=0.811, specificity=0.687). The internal consistency of Q-CHAT was 0.764 for the overall sample and 0.825 for the hospital sample. Q-CHAT total scores and item scores in the hospital sample remained stable across age groups, indicating age-invariant properties. The hospital sample showed higher endorsement of less favorable development in social interaction and reciprocity items compared to community sample. No difference in the Q-CHAT item scores was present among age groups in the hospital samples. In the community samples, item scores, such as comprehending a child’s speech, using the hand of others as a tool, adapting to a change in routine, repeating the same action, and making unusual finger movements, decreased with the advance of age. Conclusion The Korean version of the Q-CHAT demonstrates good validity and reliability and is effective in discriminating autistic traits even in children older than 24 months. The items endorsed for hospital samples varied from community samples, implying item-specific sensitivity for hospital samples.

This study compared and evaluated the color change and fracture resistance of reattached tooth fragments stored in different media after trauma. Sixty extracted permanent incisors were examined. Tap water, saline solution, milk, artificial saliva, and casein phosphopeptide-amorphous calcium and phosphate (CPP-ACP) were used as storage media. The control group used no storage media. Color changes were calculated using CIE L*a*b* values measured by a spectrophotometer at seven time points: just before reproducing the tooth fracture (T0); after drying the fractured crown for 24 hours following fracture (T1); immediately after rehydration in the storage medium for 20 minutes (T2); and 12 hours (T3), 24 hours (T4), 1 week (T5), and 3 weeks (T6) after reattaching the fractured crown. Fracture resistance was uniformly measured 3 weeks after reattachment. The results showed that the CPPACP group showed significantly more effective color recovery than the other storage media groups, with the color returning to natural levels by T2. Color recovery was observed in all groups at T6. Fracture resistance did not differ significantly between the six groups. No significant difference was observed between the storage media regarding color recovery and fracture resistance three weeks after reattachment.

Objective: This study aimed to evaluate the utility of the Korean version of the Quantitative Checklist for Autism in Toddlers (Q-CHAT) in hospital settings and to identify items sensitive for detecting autism spectrum disorder (ASD) trait. Methods: The Q-CHAT was administered to a clinical sample of children presenting with developmental delays with a high probability of ASD in a hospital setting (n=37), as well as to typically developing community children (n=67), aged 12 to 54 months. Results: The mean Q-CHAT total score in the hospital sample (42.0±13.6) was significantly higher than in the community sample (29.9±7.8), with maximized sensitivity and adequate specificity at 32.5 (sensitivity=0.811, specificity=0.687). The internal consistency of Q-CHAT was 0.764 for the overall sample and 0.825 for the hospital sample. Q-CHAT total scores and item scores in the hospital sample remained stable across age groups, indicating age-invariant properties. The hospital sample showed higher endorsement of less favorable development in social interaction and reciprocity items compared to community sample. No difference in the Q-CHAT item scores was present among age groups in the hospital samples. In the community samples, item scores, such as comprehending a child’s speech, using the hand of others as a tool, adapting to a change in routine, repeating the same action, and making unusual finger movements, decreased with the advance of age. Conclusion The Korean version of the Q-CHAT demonstrates good validity and reliability and is effective in discriminating autistic traits even in children older than 24 months. The items endorsed for hospital samples varied from community samples, implying item-specific sensitivity for hospital samples.

Purpose: HLA-DR(–) is a well-known characteristic of acute promyelocytic leukemia (APL), but also observed in some acute myeloid leukemia (AML) patients without PML::RARA fusion gene. We investigated the prevalence of clonal hematopoiesis of indeterminate potential (CHIP), immunophenotypic and cytogenetic abnormalities of HLA-DR(–) AML patients by comparing with those of APL patients. Materials and Methods: Thirteen patients diagnosed with HLA-DR(–) AML were enrolled. Twenty patients diagnosed with APL were assigned as a control group. Next-generation sequencing of CHIP genes (58 genes) was performed. Bone marrow or peripheral blood samples were used for flow cytometry to immunophenotype the leukemic blasts according to the laboratory protocol. Results: In HLA-DR(–) AML patients, CD117 positivity was less frequent. CD13 showed lower expression level. The median number of variants was three per patient, which was significantly higher than in the APL group. NPM1 variants were found in five patients. FLT3-ITD was frequently co-existed with NPM1 variant. Conclusion HLA-DR(–) AML patients exhibit a higher frequency of complex genetic abnormalities (three or more), which may explain why their prognosis is worse than that of APL patients, despite the frequent observation of NPM1. It is necessary to gather the results for each gene and conduct further evaluation.

Sleep disorders represent multifaceted pathophysiological conditions beyond simple sleep duration or quality disruptions. They are frequently associated with neuropsychiatric symptoms, cognitive decline, and systemic health deterioration. Among them, insomnia and obstructive sleep apnea (OSA) are highly prevalent and chronic, with established links to reduced quality of life and an increased risk of neurodegenerative diseases. This review summarized recent findings from neuroimaging studies that used quantitative cerebral blood flow (CBF) techniques, including arterial spin labeling (ASL) and single-photon emission computed tomography (SPECT), to examine functional brain changes associated with these disorders. Both insomnia and OSA consistently showed perfusion abnormalities in regions such as the prefrontal cortex, cingulate cortex, and hippocampus—areas that are critical for the sleep-arousal cycle, emotional regulation, and cognitive control. These alterations may reflect underlying mechanisms that include hemodynamic dysregulation, impaired metabolic regulation, and reduced connectivity in large-scale brain networks.Collectively, the evidence suggested that sleep disorders should be understood not merely as disturbances of sleep architecture, but as conditions involving cerebral hemodynamic dysregulation. Brain perfusion metrics thus hold clinical promise as sensitive biomarkers for early diagnosis, risk stratification, and treatment monitoring in sleep disorders and support the development of precision-guided interventions based on quantitative neuroimaging.