1.Rescue Intraventricular Thrombolysis for Intraventricular Hemorrhage in Moyamoya disease: A Case Report and Literature Review
Yoseb OH ; Dong-Wan KANG ; Hyung Seok GUK ; Yong Soo KIM ; Han-Gil JEONG ; Sung Dae IM ; Seung Bin SUNG ; Tae Won CHOI ; Sang Hyo LEE ; Si Un LEE ; Jae Seung BANG
Journal of Neurointensive Care 2025;8(2):52-56
Hemorrhagic moyamoya disease (MMD) often manifests with pure intraventricular hemorrhage (IVH) or intracerebral hemorrhage (ICH) with IVH, causing increased intracranial pressure (ICP) and neurological decline. Although intraventricular injection of recombinant tissue plasminogen activator (rt-PA) has been proven safe, its safety in MMD is uncertain. We introduce a case of rescue intraventricular rt-PA injection for an ICP crisis caused by IVH in MMD. A patient with MMD presented with acute ICH with IVH. Bilateral external ventricular drains (EVD) were placed, but the both EVD lost patency immediately due to an intraventricular clot. The next day, due to increased ICP, we injected rt-PA into the right EVD catheter to facilitate intraventricular drainage and reduce clot burden. After injection, IVH volume and ICP decreased significantly without rebleeding, leading to gradual neurological improvement. Intraventricular rt-PA effectively reduced ICP and IVH burden without rebleeding in hemorrhagic MMD, warranting further safety studies.
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