Background: Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. Statin therapy is the primary approach to dyslipidemia management in T2D, however, the role of non-statin therapy remains unclear. Ezetimibe reduces cholesterol burden by inhibiting intestinal cholesterol absorption. Fibrates lower triglyceride levels and increase high-density lipoprotein cholesterol (HDL-C) levels via peroxisome proliferator- activated receptor alpha agonism. Therefore, when combined, these drugs effectively lower non-HDL-C levels. Despite this, few clinical trials have specifically targeted non-HDL-C, and the efficacy of triple combination therapies, including statins, ezetimibe, and fibrates, has yet to be determined. Methods: This is a multicenter, prospective, randomized, open-label, active-comparator controlled trial involving 3,958 eligible participants with T2D, cardiovascular risk factors, and elevated non-HDL-C (≥100 mg/dL). Participants, already on moderate-intensity statins, will be randomly assigned to either Ezefeno (ezetimibe/fenofibrate) addition or statin dose-escalation. The primary end point is the development of a composite of major adverse cardiovascular and diabetic microvascular events over 48 months. Conclusion This trial aims to assess whether combining statins, ezetimibe, and fenofibrate is as effective as, or possibly superior to, statin monotherapy intensification in lowering cardiovascular and microvascular disease risk for patients with T2D. This could propose a novel therapeutic approach for managing dyslipidemia in T2D.

This study describes a unique case of single mucin-rich brain metastasis in a patient with breast cancer, mimicking the T2-fluid attenuation inversion recovery (FLAIR) mismatch sign and masquerading as an isocitrate dehydrogenase-mutant astrocytoma. This case highlights the importance of considering mucin-rich lesions in the differential diagnosis of intracranial tumors exhibiting T2-FLAIR mismatch. Clinicians must recognize the potential convergence in imaging characteristics between these metastases and gliomas to guarantee prompt and accurate patient care.

In fully edentulous patients with severe mandibular alveolar bone resorption, the retention and stability of a mandibular complete denture may be limited. There are two primary impression techniques for complete denture fabrication: the open-mouth impres-sion technique and the closed-mouth impression technique. These two methods differ in how they achieve retention and stability, and each has its own advantages and disadvantages. The study aims to compare the difference in supporting area, retention, and patient satisfaction between mandibular complete dentures fabricated using two impression techniques: the open-mouth impres-sion technique and the closed-mouth impression technique.

In fully edentulous patients with severe mandibular alveolar bone resorption, the retention and stability of a mandibular complete denture may be limited. There are two primary impression techniques for complete denture fabrication: the open-mouth impres-sion technique and the closed-mouth impression technique. These two methods differ in how they achieve retention and stability, and each has its own advantages and disadvantages. The study aims to compare the difference in supporting area, retention, and patient satisfaction between mandibular complete dentures fabricated using two impression techniques: the open-mouth impres-sion technique and the closed-mouth impression technique.

This study describes a unique case of single mucin-rich brain metastasis in a patient with breast cancer, mimicking the T2-fluid attenuation inversion recovery (FLAIR) mismatch sign and masquerading as an isocitrate dehydrogenase-mutant astrocytoma. This case highlights the importance of considering mucin-rich lesions in the differential diagnosis of intracranial tumors exhibiting T2-FLAIR mismatch. Clinicians must recognize the potential convergence in imaging characteristics between these metastases and gliomas to guarantee prompt and accurate patient care.

In recent years, next-generation sequencing (NGS)–based genetic testing has become crucial in cancer care. While its primary objective is to identify actionable genetic alterations to guide treatment decisions, its scope has broadened to encompass aiding in pathological diagnosis and exploring resistance mechanisms. With the ongoing expansion in NGS application and reliance, a compelling necessity arises for expert consensus on its application in solid cancers. To address this demand, the forthcoming recommendations not only provide pragmatic guidance for the clinical use of NGS but also systematically classify actionable genes based on specific cancer types. Additionally, these recommendations will incorporate expert perspectives on crucial biomarkers, ensuring informed decisions regarding circulating tumor DNA panel testing.

In fully edentulous patients with severe mandibular alveolar bone resorption, the retention and stability of a mandibular complete denture may be limited. There are two primary impression techniques for complete denture fabrication: the open-mouth impres-sion technique and the closed-mouth impression technique. These two methods differ in how they achieve retention and stability, and each has its own advantages and disadvantages. The study aims to compare the difference in supporting area, retention, and patient satisfaction between mandibular complete dentures fabricated using two impression techniques: the open-mouth impres-sion technique and the closed-mouth impression technique.