46XY simple gonadal hypoplasia, also known as Sweyer syndrome, patients often due to primary amenorrhea or pubertal secondary sex characteristics do not develop the doctor, its combined gonadal tumor is more likely, in the treatment process is often recommended prophylactic removal of gonads, postoperative hormone replacement therapy. We describe two patients diagnosed with Sweyer syndrome, one with gonadowlastoma and mature teratoma, and one with nodular Leydig cell hyperplasia and ectopic adrenal tissue, and reviews the literature.

Objective:To design a simulated navigation scheme of cranial puncture based on three dimensional (3D) infrared optical locator,so as to achieve accurately puncture of trigeminal nerve semilunar node and ensure maximization of the effect of clinical surgery. Methods:The experiment used computed tomography (CT) to scan skull phantom,and imported its data into 3D Slicer system. Spatial coordinates of skull phantom,surgical tool,surgical needle and needle tips were converted to 3D Slicer through the 3D optical locator and 3D Slicer's image guided therapy (IGT) module,so as to display the relationship of spatial position between needle tip and skull model in real-time,and to verify the accuracy of actual measurement of 3D optical locator,and the located accuracy of navigation scheme of skull puncture. Results:After the verification of 10 verification tests,the defined accuracy of 3D optical locator reached 0.2 mm. The operation of virtual world of 3D Slicer system can real-timely and accurately correspond with that of real world. The measured result of simulated navigation and position was (0.87±0.49) mm. Conclusion:The testing results verify the accuracy of navigation of simulated cranial puncture,which has favorable effect,and which can provide a reference for planning navigation scheme before percutaneous puncture balloon compression (PBC) surgery.

Objective:To design a simulated navigation scheme of cranial puncture based on three dimensional (3D) infrared optical locator,so as to achieve accurately puncture of trigeminal nerve semilunar node and ensure maximization of the effect of clinical surgery. Methods:The experiment used computed tomography (CT) to scan skull phantom,and imported its data into 3D Slicer system. Spatial coordinates of skull phantom,surgical tool,surgical needle and needle tips were converted to 3D Slicer through the 3D optical locator and 3D Slicer's image guided therapy (IGT) module,so as to display the relationship of spatial position between needle tip and skull model in real-time,and to verify the accuracy of actual measurement of 3D optical locator,and the located accuracy of navigation scheme of skull puncture. Results:After the verification of 10 verification tests,the defined accuracy of 3D optical locator reached 0.2 mm. The operation of virtual world of 3D Slicer system can real-timely and accurately correspond with that of real world. The measured result of simulated navigation and position was (0.87±0.49) mm. Conclusion:The testing results verify the accuracy of navigation of simulated cranial puncture,which has favorable effect,and which can provide a reference for planning navigation scheme before percutaneous puncture balloon compression (PBC) surgery.

OBJECTIVE:To evaluate the dissolution curves similarity of generic and original preparation of Losartan potassium tablets,and to provide reference for improving quality evaluation of the preparation.METHODS:Using hydrochloric acid solution (pH 3.0),phosphate buffer solution(pH 4.5),phosphate buffer solution (pH 6.8) and water as medium,paddle method was adopted for dissolution test with dissolution medium volume of 900 mL and rotation speed of 50 r/min.UV-visible spectrophotometry was adopted to determine accumulative dissolution of generic and original preparation of Losartan potassium tablets with the detection wavelength of 256 um.The similarity of dissolution curves were evaluated by calculating similarity factor(f2).RESULTS:The linear range of losartan potassium was 12.11-35.96 μg/mL (r≥0.999 7).RSDs of precision,stability and reproducibility tests were all lower than 5.0％.The recoveries of 4 dissolution media were 98.66％-100.84％ (RSD=0.77％,n=9),98.91％-100.59％ (RSD=0.49％,n=9),98.33％-101.39％ (RSD=0.85％,n=9),99.46％-101.32％ (RSD=0.55％,n=9).In 4 dissolution media,f2 of the dissolution curves of 3 batches of generic and original preparation of Losartan potassium tablets were all higher than 70.CONCLUSIONS:The dissolution curves of self-made and original preparation of Losartan potassium tablets show good similarity.