Objective To discuss the application and practice of TBL teaching mode in the clinical teaching of oncology . Methods Physicians on rotational medical tour in Huadong hospital from April 2017 to August 2017 were selected as research sub-jects, and were randomly divided into 2 groups:the experimental group and the control group .Theory test and manipulation test scores were compared and analyzed between the physicians of the 2 groups.Questionnaire feedback was used to evaluate the effect of TBL teaching mode.Results Total average scores of the experimental group were 84.15 ±4.50, while those of the control group were 78.80 ±2.38, and statistically significance could be noted , when comparisons were made between the 2 groups.Results of the questionnaire survey indicated that most of the students thought that TBL teaching mode was more beneficial to comprehensive grasp of oncology knowl -edge , and TBL teaching mode was more interesting , as compared with the conventional teaching mode .More importantly , TBL teaching mode could not only improve their learning initiative , but enhance the spirit of teamwork and cooperation .Conclusion The application of TBL teaching mode in oncology clinical teaching could fully improve learning initiative of the students , strengthen the spirit of team-work, and enhance the quality of teaching .