Objective:To systematically evaluate the associations of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) with post-stroke depression (PSD).Methods:PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang databases were searched to collect literature comparing levels of CRP, IL-6, and TNF-α at the peripheral blood between PSD and non-PSD patients, with retrieval time limit from inception to June 2024. Literature was screened according to inclusion and exclusion criteria, and data were extracted. Newcastle-Ottawa Scale (NOS) was used to assess the quality of included literature. Meta analysis was conducted using Stata 18.0 software, and publication bias was assessed.Results:A total of 21 pieces of literature with 3,177 participants were collected, including 1,425 patients with PSD and 1,752 patients with non-PSD. Meta analysis results showed that CRP level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients (standardized mean difference [ SMD]=0.930, 95% CI: 0.580-1.280, P<0.001). Subgroup analysis results showed that, among the 7 pieces of literature with CRP detection<14 days after stroke, CRP level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients ( SMD=0.640, 95% CI: 0.38-0.89, I2=83.9%, P<0.001); among the 4 pieces of literature with CRP detection≧14 days after stroke, CRP level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients ( SMD=1.450, 95% CI: 0.820-2.090, P<0.001), enjoying higher heterogeneity ( I2=90.6%). IL-6 level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients ( SMD=2.659, 95% CI: 1.583-3.735, P<0.001). No significant difference in TNF-α level at the peripheral blood was noted between PSD patients and non-PSD patients ( SMD=0.403, 95% CI: -0.208-1.014, P=0.196). Conclusion:CRP and IL-6 levels at the peripheral blood in PSD patients are obviuosly higher than those in non-PSD patients, suggesting that CRP and IL-6 may be potential biomarkers for early identification and intervention of PSD.

Objective:To investigate the relationship between dietary behavior and sarcopenia in older adults aged ≥65 years in longevity areas of China based on latent class analysis.Methods:A total of 4 358 older adults aged ≥65 years were selected from the 2021 Healthy Aging and Biomarkers Cohort Study. The information about their demographic characteristics, lifestyles, and chronic disease histories were collected. A simplified food frequency questionnaire was used to collect information about their dietary intake in the last month. The food intake frequency and food category score were calculated, and the higher the food category score, the richer the dietary intake. Latent class analysis was used to identify the latent classes of the dietary behavior. Sarcopenia was diagnosed using the SARC-CalF. Multivariate logistic regression model was used to analyze the association of food category scores and different latent classes of the dietary behavior with the risk for sarcopenia.Results:In 4 358 older adults, 1 841 (42.24%) had sarcopenia. The frequencies of intakes of cereals and potatoes, vegetable and fruit, meat and bean products were lower in the sarcopenia group than in the non-sarcopenia group. The risk for sarcopenia decreased with the increase of food category score in older adults ( OR=0.850, 95% CI: 0.796-0.907). Latent class analysis identified 4 latent classes of the dietary behavior. Compared with those with class 1 (frequency of intake of all 5 food species was higher probability in T3 group), those with class 2 (frequency of intake of vegetables and fruits and energy-only foods were less likely to be in the T3 group) and class 3 (frequency of intake of all 5 food species was lower probability in T3 group) had significantly increased risk for sarcopenia ( OR=1.377, 95% CI: 1.131-1.676) and ( OR=1.354, 95% CI: 1.091-1.680), 37.7% and 35.4% increased risk for sarcopenia, respectively. Conclusion:Increasing dietary intake category and sufficient intake of various foods for a balanced dietary pattern can reduce the risk of sarcopenia in older adults.

Objective:To explore the relationships between physical activity and cognitive impairment in older adults aged ≥65 years in longevity areas in China.Methods:A total of 6 081 older adults aged ≥65 years from the Healthy Ageing and Biomarkers Cohort Study in China in 2021 were included in this study. Information about their demographic characteristics, lifestyles, and chronic disease histories were collected, the intensity of physical activity was evaluated by using Physical Activity Scale for the Elderly, and the cognitive function was evaluated by using Mini-Mental State Examination Scale (Chinese version). Multifactorial logistic regression model was used to analyze the associations between different levels and types of physical activity and cognitive impairment in older adults.Results:In the 6 081 older adults, 1 829 (30.1%) had cognitive impairment. After adjusting for confounders, older adults with T2 and T3 levels of physical activity had lower risks for cognitive impairment compared with those with T1 levels of physical activity, with ORs of 0.47 (95% CI: 0.40-0.55) and 0.22 (95% CI: 0.18-0.28). The results of different types of physical activities showed that the ORs in leisure activity T2 and T3 groups were 0.52 (95% CI: 0.44-0.63) and 0.49 (95% CI: 0.41-0.58), and the ORs in housework activity T2 and T3 groups were 0.36 (95% CI: 0.30-0.42) and 0.19 (95% CI: 0.16-0.24). There was no significant association between work-related activity and cognitive impairment. Conclusion:There is a negative association between the intensity level of physical activity and cognitive impairment, and active leisure and household activities might reduce the risk for cognitive impairment.

Objective:To construct a performance assessment system based on the supply chain operations reference(SCOR)model for medical consumables,and explore its application effect in management for medical consumables of hospital.Methods:Based on the SCOR framework,the performance indicators such as cost,management for asset,flexibility,reliability and response speed were selected to construct a performance assessment system based on SCOR for medical consumables.A total of 585 batches of medical consumables that were used clinically in our hospital from November 2022 to October 2024 were selected,and 268 batches of them that were used during November 2022 to October 2023 were managed by using conventional management mode(conventional management mode)for medical consumables,and 317 batches of them that were used during November 2023 to October 2024 were managed by using the management mode with performance assessment system(performance management mode)based on SCOR for medical consumables.The management efficiency and the score of management quality of two management modes for medical consumables were compared.Results:The review duration,average turnover efficiency in hospital,average turnover efficiency out of hospital,average occupancy rate of inventory capital,and the number of monthly average rush order of adopting performance management mode were respectively(0.89±0.26)d,(0.83±0.32)%,(0.76±0.17)%,(0.23±0.03)%and(3.58±0.89)times,all of which were lower than those of conventional management mode,and the differences were significant(t=17.139,34.836,42.851,29.747,27.878,P<0.05).The scores in different dimensions included management methods,counting and transportation for medical consumables,and management contents and forms for medical consumables of adopting performance management mode were significantly higher than those of adopting conventional management mode,and the differences were significant(t=14.629,11.239,10.891,12.696,10.830,P<0.05).Conclusion:The performance assessment system based on SCOR for medical consumables can improve the efficiency and quality of management for medical consumables,and reduce occupation for capital,and promote sustainable economic development of hospitals.

Objective To investigate the predictive value of serum vasoactive intestinal peptide(VIP)and 5-hydroxytryptamine(5-HT)levels on the outcome of spinal cord electrical stimulation(SCS)in patients with postherpetic neuralgia(PHN).Methods A total of 96 PHN patients who received SCS treatment in Ziy-ang Central Hospital from January 2022 to December 2023 were selected.According to the disease outcomes of all PHN patients after 6 months of treatment,a good group(n=71)and a poor group(n=25)were set up.The clinical data of the two groups were collected and the serum VIP and 5-HT levels were detected in all pa-tients before treatment.The predictive value of serum VIP and 5-HT on disease outcome after SCS treatment in PHN patients was evaluated by receiver operating characteristic(ROC)curve,and the influencing factors of disease outcome after SCS treatment in PHN patients was explored by multivariate Logistic steppe gression a-nalysis.Results The levels of serum VIP and 5-HT in poor group were higher than those in good group(P＜0.05).The area under the curve(AUC)of serum VIP and 5-HT for predicting the disease outcome of PHN patients after SCS treatment were 0.829(95％CI:0.779-0.874)and 0.743(95％CI:0.693-0.793),respec-tively,and the AUC of combined prediction was 0.941(0.891-0.986).There were no significant differences in age,gender,body moss index,education,location of onset,hypertension and drinking history between the two groups(P＞0.05).The time of initial hospital admission in the poor group was longer than that in the good group,skin rash area in the poor group was larger than that in the good group,and diabetes mellitus and smoking history in the poor group were higher than those in the good group(P＜0.05).The time of admis-sion for initial treatment＞3 d(OR=2.188,95％CI:1.383-3.461),skin rash area＞10 cm2(OR=2.018,95％CI:1.283-3.173),diabetes mellitus(OR=2.264,95％CI:1.379-3.717),serum VIP level ≥41.78 ng/L(OR=3.022,95％CI:1.685-5.420),serum 5-HT level ≥99.27 ng/mL(OR=3.579,95％CI:1.885-6.793)were the influencing factors of disease outcome after SCS treatment in PHN patients(P＜0.05).Con-clusion The elevated levels of serum VIP and 5-HT before treatment are associated with poor outcomes after SCS in patients with PHN,and could be used as potential markers to predict the outcomes of SCS in patients with PHN.

ObjectiveTo establish the specific chromatogram and quantitative analysis of multi-components by single-marker（QAMS） based on linear calibration using two reference substances（LCTRS）， explore the consistency between Hedyotis Herba dispensing granules and standard decoction， and evaluate the quality of the dispensing granules. MethodsHigh performance liquid chromatography（HPLC） specific chromatogram was established based on 15 batches of Hedyotis Herba standard decoction and 10 batches of the dispensing granules， and LCTRS was used to locate chromatographic peaks. The actual retention times of 7 characteristic peaks in the specific chromatogram was measured on 24 different types of C₁₈ columns， taking deacetyl asperulosidic acid and asperulosidic acid as the dual standard compounds， the retention times of the other 5 characteristic peaks were predicted and validated. Based on this， QAMS was developed to determine the contents of four components（deacetyl asperulosidic acid， deacetyl asperulosidic acid methyl ester， asperulosidic acid， and p-coumaric acid）. Then， the relative correction factors of deacetyl asperulosidic acid， deacetyl asperulosidic acid methyl ester and p-coumaric acid were calculated using the reference peak of asperulosidic acid in the dual standard compounds， and each component was quantified accordingly. Finally， the consistency between the dispensing granules and standard decoction was assessed by taking extract rate of the standard decoction， consistency of the specific chromatograms， contents and transfer rates of the indicator components as indexes， and the quality of the dispensing granules was evaluated. ResultsThere were 7 common peaks in the characteristic chromatogram of samples of Hedyotis Herba standard decoction and the dispensing granules， and four of them were identified by reference standards， namely deacetyl asperulosidic acid（peak 1）， deacetyl asperulosidic acid methyl ester（peak 3）， asperulosidic acid（peak 6） and p-coumaric acid（peak 7）. The similarity between the dispensing granules and the standard decoction was >0.9. The absolute deviation in the predicted retention time for each component by LCTRS was lower than that of the relative retention time method. The extract rate of the 15 batches of Hedyotis Herba standard decoction ranged from 7.89% to 14.60%， the contents of deacetyl asperulosidic acid， deacetyl asperulosidic acid methyl ester， asperulosidic acid and p-coumaric acid were 6.62-19.70， 3.83-17.99， 1.57-6.69， 1.62-4.52 mg·g^-1， and the transfer rates of these components from decoction pieces to the standard decoction were 22.89%-39.60%， 34.03%-62.24%， 24.25%-43.70%， and 40.58%-73.71%， respectively. The extract rate， index component contents and transfer rates from decoction pieces to the three batches of Hedyotis Herba dispensing granules（P1-P3）， produced by manufacturer A， were similar to those of the standard decoction prepared from the same batch of decoction pieces， and all fell within the specified range. The contents of the 4 indicator components in 7 batches of the dispensing granules（P4-P10） from manufacturers B-E were all within the range of the content converted from the standard decoction based on the quantity of the dispensing granules. ConclusionThe established specific chromatogram and QAMS based on LCTRS are reasonable and reliable. Based on the evaluation indicators of standard decoction yield， consistency of specific chromatograms， contents and transfer rates of the four index components， the 10 batches of Hedyotis Herba dispensing granules from various manufacturers have exhibited good consistency with the standard decoction， indicating that the current production process is relatively reasonable.

Objective:To systematically evaluate the associations of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) with post-stroke depression (PSD).Methods:PubMed, Embase, Cochrane Library, Web of Science, CNKI, and Wanfang databases were searched to collect literature comparing levels of CRP, IL-6, and TNF-α at the peripheral blood between PSD and non-PSD patients, with retrieval time limit from inception to June 2024. Literature was screened according to inclusion and exclusion criteria, and data were extracted. Newcastle-Ottawa Scale (NOS) was used to assess the quality of included literature. Meta analysis was conducted using Stata 18.0 software, and publication bias was assessed.Results:A total of 21 pieces of literature with 3,177 participants were collected, including 1,425 patients with PSD and 1,752 patients with non-PSD. Meta analysis results showed that CRP level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients (standardized mean difference [ SMD]=0.930, 95% CI: 0.580-1.280, P<0.001). Subgroup analysis results showed that, among the 7 pieces of literature with CRP detection<14 days after stroke, CRP level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients ( SMD=0.640, 95% CI: 0.38-0.89, I2=83.9%, P<0.001); among the 4 pieces of literature with CRP detection≧14 days after stroke, CRP level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients ( SMD=1.450, 95% CI: 0.820-2.090, P<0.001), enjoying higher heterogeneity ( I2=90.6%). IL-6 level at the peripheral blood in PSD patients was significantly higher than that in non-PSD patients ( SMD=2.659, 95% CI: 1.583-3.735, P<0.001). No significant difference in TNF-α level at the peripheral blood was noted between PSD patients and non-PSD patients ( SMD=0.403, 95% CI: -0.208-1.014, P=0.196). Conclusion:CRP and IL-6 levels at the peripheral blood in PSD patients are obviuosly higher than those in non-PSD patients, suggesting that CRP and IL-6 may be potential biomarkers for early identification and intervention of PSD.

Objective:To investigate the relationship between dietary behavior and sarcopenia in older adults aged ≥65 years in longevity areas of China based on latent class analysis.Methods:A total of 4 358 older adults aged ≥65 years were selected from the 2021 Healthy Aging and Biomarkers Cohort Study. The information about their demographic characteristics, lifestyles, and chronic disease histories were collected. A simplified food frequency questionnaire was used to collect information about their dietary intake in the last month. The food intake frequency and food category score were calculated, and the higher the food category score, the richer the dietary intake. Latent class analysis was used to identify the latent classes of the dietary behavior. Sarcopenia was diagnosed using the SARC-CalF. Multivariate logistic regression model was used to analyze the association of food category scores and different latent classes of the dietary behavior with the risk for sarcopenia.Results:In 4 358 older adults, 1 841 (42.24%) had sarcopenia. The frequencies of intakes of cereals and potatoes, vegetable and fruit, meat and bean products were lower in the sarcopenia group than in the non-sarcopenia group. The risk for sarcopenia decreased with the increase of food category score in older adults ( OR=0.850, 95% CI: 0.796-0.907). Latent class analysis identified 4 latent classes of the dietary behavior. Compared with those with class 1 (frequency of intake of all 5 food species was higher probability in T3 group), those with class 2 (frequency of intake of vegetables and fruits and energy-only foods were less likely to be in the T3 group) and class 3 (frequency of intake of all 5 food species was lower probability in T3 group) had significantly increased risk for sarcopenia ( OR=1.377, 95% CI: 1.131-1.676) and ( OR=1.354, 95% CI: 1.091-1.680), 37.7% and 35.4% increased risk for sarcopenia, respectively. Conclusion:Increasing dietary intake category and sufficient intake of various foods for a balanced dietary pattern can reduce the risk of sarcopenia in older adults.

Objective:To explore the relationships between physical activity and cognitive impairment in older adults aged ≥65 years in longevity areas in China.Methods:A total of 6 081 older adults aged ≥65 years from the Healthy Ageing and Biomarkers Cohort Study in China in 2021 were included in this study. Information about their demographic characteristics, lifestyles, and chronic disease histories were collected, the intensity of physical activity was evaluated by using Physical Activity Scale for the Elderly, and the cognitive function was evaluated by using Mini-Mental State Examination Scale (Chinese version). Multifactorial logistic regression model was used to analyze the associations between different levels and types of physical activity and cognitive impairment in older adults.Results:In the 6 081 older adults, 1 829 (30.1%) had cognitive impairment. After adjusting for confounders, older adults with T2 and T3 levels of physical activity had lower risks for cognitive impairment compared with those with T1 levels of physical activity, with ORs of 0.47 (95% CI: 0.40-0.55) and 0.22 (95% CI: 0.18-0.28). The results of different types of physical activities showed that the ORs in leisure activity T2 and T3 groups were 0.52 (95% CI: 0.44-0.63) and 0.49 (95% CI: 0.41-0.58), and the ORs in housework activity T2 and T3 groups were 0.36 (95% CI: 0.30-0.42) and 0.19 (95% CI: 0.16-0.24). There was no significant association between work-related activity and cognitive impairment. Conclusion:There is a negative association between the intensity level of physical activity and cognitive impairment, and active leisure and household activities might reduce the risk for cognitive impairment.

Objective:To construct a performance assessment system based on the supply chain operations reference(SCOR)model for medical consumables,and explore its application effect in management for medical consumables of hospital.Methods:Based on the SCOR framework,the performance indicators such as cost,management for asset,flexibility,reliability and response speed were selected to construct a performance assessment system based on SCOR for medical consumables.A total of 585 batches of medical consumables that were used clinically in our hospital from November 2022 to October 2024 were selected,and 268 batches of them that were used during November 2022 to October 2023 were managed by using conventional management mode(conventional management mode)for medical consumables,and 317 batches of them that were used during November 2023 to October 2024 were managed by using the management mode with performance assessment system(performance management mode)based on SCOR for medical consumables.The management efficiency and the score of management quality of two management modes for medical consumables were compared.Results:The review duration,average turnover efficiency in hospital,average turnover efficiency out of hospital,average occupancy rate of inventory capital,and the number of monthly average rush order of adopting performance management mode were respectively(0.89±0.26)d,(0.83±0.32)%,(0.76±0.17)%,(0.23±0.03)%and(3.58±0.89)times,all of which were lower than those of conventional management mode,and the differences were significant(t=17.139,34.836,42.851,29.747,27.878,P<0.05).The scores in different dimensions included management methods,counting and transportation for medical consumables,and management contents and forms for medical consumables of adopting performance management mode were significantly higher than those of adopting conventional management mode,and the differences were significant(t=14.629,11.239,10.891,12.696,10.830,P<0.05).Conclusion:The performance assessment system based on SCOR for medical consumables can improve the efficiency and quality of management for medical consumables,and reduce occupation for capital,and promote sustainable economic development of hospitals.