Objective To investigate the relationship between serum microRNA-101-3p(miR-101-3p),pol-ypeptide N-acetylgalactosaminyltransferase 1(GALNT1)and the efficacy and prognosis of neoadjuvant chem-otherapy(NAC)in breast cancer.Methods A total of 203 breast cancer patients who underwent NAC in this hospital from January 2017 to August 2019 were selected as breast cancer group.They were divided into the ineffective group and the effective group according to the therapeutic effect of NAC,and divided into the death group and the survival group according to the 5-year survival situation.Additionally,203 healthy women who underwent routine physical examination during the same period were selected as the control group.The clini-cal data and the levels of serum miR-101-3p and GALNT1 were detected and compared.The binding sites of miR-101-3p and GALNT1 were predicted through the online database.Pearson correlation analysis was per-formed to assess the correlation between serum miR-101-3p and GALNT1 expression in breast cancer pa-tients.The relationship between serum miR-101-3p,GALNT1 and the efficacy and prognosis of NAC in breast cancer patients were analyzed by multivariate unconditional Logistic regression and Cox regression.The pre-dictive value of serum miR-101-3p and GALNT1 for the ineffectiveness and mortalit of NAC treatment in breast cancer patients were analyzed by receiver operating characteristic(ROC)curve.Results Compared with the control group,the expression level of serum miR-101-3p in the breast cancer group decreased,and the level of GALNT1 increased,and the differences were statistically significant(P＜0.05).Serum miR-101-3p in patients with breast cancer was negatively correlated with GALNT1(P＜0.05).High expression of Ki-67,≥4 axillary lymph node metastases after surgery and high expression of GALNT1 were independent risk factors for ineffective NAC treatment in breast cancer patients(P＜0.05),and high expression of miR-101-3p was an independent protective factor(P＜0.05).TNM stage Ⅲ,postoperative axillary lymph node metastasis ≥10,and high expression of GALNT1 were independent risk factors for ineffective NAC treatment in breast cancer patients(P＜0.05),while high expression of miR-101-3p was an independent protective fac-tor(P＜0.05).The predictive efficacy of combined detection of serum miR-101-3p and GALNT1 for ineffec-tive NAC treatment and death in breast cancer patients was higher than that predicted by either of them alone(both P＜0.05).Conclusion Low serum miR-101-3p and high GALNT1 expression in breast cancer patients are closely related to NAC efficacy and prognosis.The combination of the two has a high predictive value for both the efficacy and prognosis of NAC.

Objective:To investigate the correlation between serum vascular endothelial growth factor (VEGF), von Willebrand factor (vWF) and coagulation index and prognosis of differentiated thyroid cancer (TC) .Methods:136 TC patients admitted in Department of Head and Neck Surgery Shanxi Cancer Hospital from Jan. 2021 to Dec. 2022 were selected as TC group, and 80 patients with confirmed thyroid benign nodule during the same period were selected as control group. VEGF, vWF and coagulation indexes were compared between the two groups. The tumor free survival was calculated by Kaplan-Meier method.Results:Compared with the control group, the levels of VEGF, vWF, TT, Fbg in TC group were higher, and the levels of PT, APTT were lower ( P < 0.001). Compared with patients < 55 years old, the levels of VEGF, vWF, TT and Fbg were higher in patients ≥55 years old, and the levels of PT and APTT were lower ( P < 0.001). Compared with papillary carcinoma, the levels of VEGF, vWF, TT and Fbg were higher in follicular carcinoma patients, and the levels of PT and APTT were lower ( P < 0.001). The levels of VEGF, vWF, TT and Fbg were higher and the levels of PT and APTT were lower in patients with TNM stage III to IV than in patients with TNM stage I to II ( P < 0.001). Compared with patients without lymph node metastasis, VEGF, vWF, TT, Fbg levels were higher in patients with lymph node metastasis, and PT, APTT levels were lower ( P < 0.001). Compared with patients with tumor size < 2 cm, VEGF and vWF levels were higher in patients with tumor size ≥ 2 cm ( P < 0.001). Survival curve analysis showed that the tumor free survival of high VEGF, high vWF, high TT and high Fbg groups was shorter than that of low VEGF, low vWF, low TT and low Fbg groups (Log-rank=9.149, 8.856, 4.683, 5.867, P < 0.001) . Conclusion:VEGF, vWF and coagulation indexes in TC patients were correlated with clinicopathological features, and were helpful to predict postoperative tumor-free survival.

Objective:To investigate the correlation between serum vascular endothelial growth factor (VEGF), von Willebrand factor (vWF) and coagulation index and prognosis of differentiated thyroid cancer (TC) .Methods:136 TC patients admitted in Department of Head and Neck Surgery Shanxi Cancer Hospital from Jan. 2021 to Dec. 2022 were selected as TC group, and 80 patients with confirmed thyroid benign nodule during the same period were selected as control group. VEGF, vWF and coagulation indexes were compared between the two groups. The tumor free survival was calculated by Kaplan-Meier method.Results:Compared with the control group, the levels of VEGF, vWF, TT, Fbg in TC group were higher, and the levels of PT, APTT were lower ( P < 0.001). Compared with patients < 55 years old, the levels of VEGF, vWF, TT and Fbg were higher in patients ≥55 years old, and the levels of PT and APTT were lower ( P < 0.001). Compared with papillary carcinoma, the levels of VEGF, vWF, TT and Fbg were higher in follicular carcinoma patients, and the levels of PT and APTT were lower ( P < 0.001). The levels of VEGF, vWF, TT and Fbg were higher and the levels of PT and APTT were lower in patients with TNM stage III to IV than in patients with TNM stage I to II ( P < 0.001). Compared with patients without lymph node metastasis, VEGF, vWF, TT, Fbg levels were higher in patients with lymph node metastasis, and PT, APTT levels were lower ( P < 0.001). Compared with patients with tumor size < 2 cm, VEGF and vWF levels were higher in patients with tumor size ≥ 2 cm ( P < 0.001). Survival curve analysis showed that the tumor free survival of high VEGF, high vWF, high TT and high Fbg groups was shorter than that of low VEGF, low vWF, low TT and low Fbg groups (Log-rank=9.149, 8.856, 4.683, 5.867, P < 0.001) . Conclusion:VEGF, vWF and coagulation indexes in TC patients were correlated with clinicopathological features, and were helpful to predict postoperative tumor-free survival.