ObjectiveTo summarize the application experience of the "Three-Separation" model in the pre-service training of laboratory animal practitioners and scientifically evaluate its training effectiveness. MethodsA retrospective analysis was conducted on 8 009 practitioners who participated in pre-service training at the Fujian Provincial Laboratory Animal Training Base from January 2010 to December 2025. Among them, 1 250 trainees from January 2010 to December 2017 were included in the control group (traditional training model), and 6 759 trainees from January 2018 to December 2025 were included in the evaluation group ("Three-Separation" model, based on separating job requirements, differentiating exam content, and categorizing exam methods). Meanwhile, a questionnaire survey was conducted to evaluate training effectiveness, yielding 1 624 valid questionnaires (585 from the control group and 1 039 from the evaluation group). The "Three-Separation" model simultaneously optimized fee structures to improve affordability and inclusiveness. The comprehensive competencies and training satisfaction of the two groups after training were compared and analyzed using the independent sample t-test, χ² test, and Wilcoxon rank-sum test. ResultsThe overall satisfaction rate of the evaluation group was 92.49% (961/1 039), significantly higher than that of the control group (77.78%, 455/585), with a highly significant difference (χ²=72.50, P<0.001). The evaluation group showed a more favorable distribution of positive, neutral, and negative ratings in dimensions such as course pertinence, time flexibility, assessment rationality, and reasonableness of fees, and the positive rating rates were highly significantly higher than those in the control group (P<0.001). The comprehensive pass rate of the evaluation group (95.53%) was significantly higher than that of the control group (86.24%), with a highly significant difference (P<0.001). ConclusionThe scientific application of the "Three-Separation" model can accurately match the competency requirements of different positions, optimize the training and assessment system, reduce participation barriers by making training fees more affordable and accessible, effectively improve the comprehensive quality and training satisfaction of laboratory animal practitioners, achieve better teaching outcomes, and provide replicable and promotable practical references for the standardized upgrading of the training system in the laboratory animal industry and other industries.

Background: and Purpose This study aimed to investigate the association between residual inflammatory risk (RIR) and vulnerable plaques using high-resolution magnetic resonance imaging (HRMRI) in symptomatic intracranial atherosclerotic stenosis (ICAS). Methods: This retrospective study included 70%–99% symptomatic ICAS patients hospitalized from January 2016 to December 2022. Patients were classified into four groups based on high-sensitivity C-reactive protein (hs-CRP) and low-density lipoprotein cholesterol (LDL-C): residual cholesterol inflammatory risk (RCIR, hs-CRP ≥3 mg/L and LDL-C ≥2.6 mmol/L), RIR (hs-CRP ≥3 mg/L and LDL-C <2.6 mmol/L), residual cholesterol risk (RCR, hs-CRP <3 mg/L and LDL-C ≥2.6 mmol/L), and no residual risk (NRR, hs-CRP <3 mg/L and LDL-C <2.6 mmol/L). Vulnerable plaque features on HRMRI included positive remodeling, diffuse distribution, intraplaque hemorrhage, and strong enhancement. Results: Among 336 included patients, 21, 60, 58, and 197 were assigned to the RCIR, RIR, RCR, and NRR groups, respectively. Patients with RCIR (adjusted odds ratio [aOR], 3.606; 95% confidence interval [CI], 1.346–9.662; P=0.011) and RIR (aOR, 3.361; 95% CI, 1.774–6.368, P<0.001) had higher risks of strong enhancement than those with NRR. Additionally, patients with RCIR (aOR, 2.965; 95% CI, 1.060–8.297; P=0.038) were more likely to have intraplaque hemorrhage compared with those with NRR. In the sensitivity analysis, RCR (aOR, 2.595; 95% CI, 1.201–5.608; P=0.015) exhibited an additional correlation with an increased risk of intraplaque hemorrhage. Conclusion In patients with symptomatic ICAS, RIR is associated with a higher risk of intraplaque hemorrhage and strong enhancement, indicating an increased vulnerability to atherosclerotic plaques.

Background: and Purpose This study aimed to investigate the association between residual inflammatory risk (RIR) and vulnerable plaques using high-resolution magnetic resonance imaging (HRMRI) in symptomatic intracranial atherosclerotic stenosis (ICAS). Methods: This retrospective study included 70%–99% symptomatic ICAS patients hospitalized from January 2016 to December 2022. Patients were classified into four groups based on high-sensitivity C-reactive protein (hs-CRP) and low-density lipoprotein cholesterol (LDL-C): residual cholesterol inflammatory risk (RCIR, hs-CRP ≥3 mg/L and LDL-C ≥2.6 mmol/L), RIR (hs-CRP ≥3 mg/L and LDL-C <2.6 mmol/L), residual cholesterol risk (RCR, hs-CRP <3 mg/L and LDL-C ≥2.6 mmol/L), and no residual risk (NRR, hs-CRP <3 mg/L and LDL-C <2.6 mmol/L). Vulnerable plaque features on HRMRI included positive remodeling, diffuse distribution, intraplaque hemorrhage, and strong enhancement. Results: Among 336 included patients, 21, 60, 58, and 197 were assigned to the RCIR, RIR, RCR, and NRR groups, respectively. Patients with RCIR (adjusted odds ratio [aOR], 3.606; 95% confidence interval [CI], 1.346–9.662; P=0.011) and RIR (aOR, 3.361; 95% CI, 1.774–6.368, P<0.001) had higher risks of strong enhancement than those with NRR. Additionally, patients with RCIR (aOR, 2.965; 95% CI, 1.060–8.297; P=0.038) were more likely to have intraplaque hemorrhage compared with those with NRR. In the sensitivity analysis, RCR (aOR, 2.595; 95% CI, 1.201–5.608; P=0.015) exhibited an additional correlation with an increased risk of intraplaque hemorrhage. Conclusion In patients with symptomatic ICAS, RIR is associated with a higher risk of intraplaque hemorrhage and strong enhancement, indicating an increased vulnerability to atherosclerotic plaques.

Background: and Purpose This study aimed to investigate the association between residual inflammatory risk (RIR) and vulnerable plaques using high-resolution magnetic resonance imaging (HRMRI) in symptomatic intracranial atherosclerotic stenosis (ICAS). Methods: This retrospective study included 70%–99% symptomatic ICAS patients hospitalized from January 2016 to December 2022. Patients were classified into four groups based on high-sensitivity C-reactive protein (hs-CRP) and low-density lipoprotein cholesterol (LDL-C): residual cholesterol inflammatory risk (RCIR, hs-CRP ≥3 mg/L and LDL-C ≥2.6 mmol/L), RIR (hs-CRP ≥3 mg/L and LDL-C <2.6 mmol/L), residual cholesterol risk (RCR, hs-CRP <3 mg/L and LDL-C ≥2.6 mmol/L), and no residual risk (NRR, hs-CRP <3 mg/L and LDL-C <2.6 mmol/L). Vulnerable plaque features on HRMRI included positive remodeling, diffuse distribution, intraplaque hemorrhage, and strong enhancement. Results: Among 336 included patients, 21, 60, 58, and 197 were assigned to the RCIR, RIR, RCR, and NRR groups, respectively. Patients with RCIR (adjusted odds ratio [aOR], 3.606; 95% confidence interval [CI], 1.346–9.662; P=0.011) and RIR (aOR, 3.361; 95% CI, 1.774–6.368, P<0.001) had higher risks of strong enhancement than those with NRR. Additionally, patients with RCIR (aOR, 2.965; 95% CI, 1.060–8.297; P=0.038) were more likely to have intraplaque hemorrhage compared with those with NRR. In the sensitivity analysis, RCR (aOR, 2.595; 95% CI, 1.201–5.608; P=0.015) exhibited an additional correlation with an increased risk of intraplaque hemorrhage. Conclusion In patients with symptomatic ICAS, RIR is associated with a higher risk of intraplaque hemorrhage and strong enhancement, indicating an increased vulnerability to atherosclerotic plaques.

Hand degloving injury represents one of the most severe forms of hand trauma, characterised by challenging treatment and a complex prognostic outcome. It is crucial to effectively utilise the degloved tissues in emergency or primary repair of a hand degloving injury. This consensus provides a comprehensive review of the existing literature on definition, classification, emergency assessment, debridement, judgment of skin viability, in situ repair of the degloved skin, and adjunctive treatment for degloving injury of hand. Based on conclusion of both domestic and international experiences, this expert consensus on the classification of hand degloving injury and the emergency repair with the avulsed skin is established, aiming to provide a guidance to surgeons on standardised treatment strategy and improve the management of hand degloving injury.

Hand degloving injury represents one of the most severe forms of hand trauma, characterised by challenging treatment and a complex prognostic outcome. It is crucial to effectively utilise the degloved tissues in emergency or primary repair of a hand degloving injury. This consensus provides a comprehensive review of the existing literature on definition, classification, emergency assessment, debridement, judgment of skin viability, in situ repair of the degloved skin, and adjunctive treatment for degloving injury of hand. Based on conclusion of both domestic and international experiences, this expert consensus on the classification of hand degloving injury and the emergency repair with the avulsed skin is established, aiming to provide a guidance to surgeons on standardised treatment strategy and improve the management of hand degloving injury.

Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.

Objective:To investigate the hemodynamic characteristics of frontal cortex and bilateral temporal lobes in patients with obsessive-compulsive disorder (OCD) during verbal fluency tasks using functional near-infrared spectroscopy (fNIRS), and assess the value of fNIRS in aiding OCD diagnosis.Methods:Clinical data of 30 OCD patients who visited the Psychology Department at Ruijin Hospital, affiliated with the Shanghai Jiaotong University School of Medicine between June 2022 and June 2023 were prospectively collected. There were 17 males and 13 females aged 16-41 years, and the education level was 9-19 years. Another 30 healthy control participants voluntarily participated in the study, including 12 males and 18 females aged 19-54 years with 9-19 years of education. Cerebral hemodynamic changes in the prefrontal and bilateral temporal lobes were detected using fNIRS during verbal fluency tasks. Specific parameters including integral values, centroid values, and slopes for both the prefrontal and bilateral temporal lobes were analyzed using independent two-sample t-tests and non-parametric Mann-Whitney U tests. Influencing indicators for OCD were analyzed using a binary logistic regression model. Receiver Operating Characteristic (ROC) curve analysis was plotted to evaluate the diagnostic performance of fNIRS indicators in distinguishing OCD patients from healthy controls, and the optimal cutoff value were calculated. Results:OCD patients generated significantly less words during the verbal fluency task compared to healthy controls ( M( Q1, Q3)) (Number of 9.0 (7.0, 12.0) vs 12.0 (10.0, 16.3), Z=2.80, P=0.005). The integral values and slopes of the frontal lobe, and the integral values of the bilateral temporal lobes, were significantly lower in OCD patient group (32.3 (-7.8, 62.2) vs 123.7 (96.2, 181.3), Z=5.76; 0.000 5±0.001 2 vs 0.001 5±0.001 6, t=-2.54; 87.0±71.4 vs 186.1±90.3, t=-4.71), while centroid values of both the frontal and bilateral temporal lobes were higher ((60.4±13.8) seconds vs (54.4±7.8) seconds, t=2.80; 60.3 (55.5, 65.0) seconds vs 56.2 (52.7, 59.2) seconds, Z=-2.42), with all the differences statistically significant (all P<0.05). No significant difference was observed in slope of bilateral temporal lobes between two groups ( t=-1.60, P=0.116). Binary logistic regression showed that integral value of frontal cortex significantly influenced OCD occurrence ( OR=0.958, 95% CI: 0.932-0.985, P=0.003). ROC analysis indicated ideal diagnostic performance of integral value of frontal lobe in distinguishing OCD patients from healthy controls with an optimal cut-off value of 68.2, sensitivity of 0.900, specificity of 0.833, and AUCs of 0.931 (95% CI: 0.869-0.993, P<0.001). AUCs of number of words generated, integral value of frontal cortex, slope of frontal cortex, integral value of bilateral temporal lobes, and centroid value of bilateral temporal lobes were 0.709 (95% CI: 0.580-0.839), 0.931 (95% CI: 0.869-0.993), 0.665 (95% CI: 0.527-0.803), 0.793 (95% CI: 0.683-0.904), and 0.682 (95% CI: 0.542-0.822), respectively (all P<0.05). Centroid value of frontal cortex showed poor diagnostic performance (AUC=0.637, 95% CI: 0.493-0.781, P=0.069). Conclusion:OCD patients generated less words and have decreased integrated values and increased centroid values of frontal cortex and bilateral temporal lobes during verbal fluency tasks. Integral values of frontal cortex significantly influence OCD occurrence and demonstrate high sensitivity and specificity in distinguishing OCD patients from healthy controls.

Objective:To investigate the hemodynamic characteristics of frontal cortex and bilateral temporal lobes in patients with obsessive-compulsive disorder (OCD) during verbal fluency tasks using functional near-infrared spectroscopy (fNIRS), and assess the value of fNIRS in aiding OCD diagnosis.Methods:Clinical data of 30 OCD patients who visited the Psychology Department at Ruijin Hospital, affiliated with the Shanghai Jiaotong University School of Medicine between June 2022 and June 2023 were prospectively collected. There were 17 males and 13 females aged 16-41 years, and the education level was 9-19 years. Another 30 healthy control participants voluntarily participated in the study, including 12 males and 18 females aged 19-54 years with 9-19 years of education. Cerebral hemodynamic changes in the prefrontal and bilateral temporal lobes were detected using fNIRS during verbal fluency tasks. Specific parameters including integral values, centroid values, and slopes for both the prefrontal and bilateral temporal lobes were analyzed using independent two-sample t-tests and non-parametric Mann-Whitney U tests. Influencing indicators for OCD were analyzed using a binary logistic regression model. Receiver Operating Characteristic (ROC) curve analysis was plotted to evaluate the diagnostic performance of fNIRS indicators in distinguishing OCD patients from healthy controls, and the optimal cutoff value were calculated. Results:OCD patients generated significantly less words during the verbal fluency task compared to healthy controls ( M( Q1, Q3)) (Number of 9.0 (7.0, 12.0) vs 12.0 (10.0, 16.3), Z=2.80, P=0.005). The integral values and slopes of the frontal lobe, and the integral values of the bilateral temporal lobes, were significantly lower in OCD patient group (32.3 (-7.8, 62.2) vs 123.7 (96.2, 181.3), Z=5.76; 0.000 5±0.001 2 vs 0.001 5±0.001 6, t=-2.54; 87.0±71.4 vs 186.1±90.3, t=-4.71), while centroid values of both the frontal and bilateral temporal lobes were higher ((60.4±13.8) seconds vs (54.4±7.8) seconds, t=2.80; 60.3 (55.5, 65.0) seconds vs 56.2 (52.7, 59.2) seconds, Z=-2.42), with all the differences statistically significant (all P<0.05). No significant difference was observed in slope of bilateral temporal lobes between two groups ( t=-1.60, P=0.116). Binary logistic regression showed that integral value of frontal cortex significantly influenced OCD occurrence ( OR=0.958, 95% CI: 0.932-0.985, P=0.003). ROC analysis indicated ideal diagnostic performance of integral value of frontal lobe in distinguishing OCD patients from healthy controls with an optimal cut-off value of 68.2, sensitivity of 0.900, specificity of 0.833, and AUCs of 0.931 (95% CI: 0.869-0.993, P<0.001). AUCs of number of words generated, integral value of frontal cortex, slope of frontal cortex, integral value of bilateral temporal lobes, and centroid value of bilateral temporal lobes were 0.709 (95% CI: 0.580-0.839), 0.931 (95% CI: 0.869-0.993), 0.665 (95% CI: 0.527-0.803), 0.793 (95% CI: 0.683-0.904), and 0.682 (95% CI: 0.542-0.822), respectively (all P<0.05). Centroid value of frontal cortex showed poor diagnostic performance (AUC=0.637, 95% CI: 0.493-0.781, P=0.069). Conclusion:OCD patients generated less words and have decreased integrated values and increased centroid values of frontal cortex and bilateral temporal lobes during verbal fluency tasks. Integral values of frontal cortex significantly influence OCD occurrence and demonstrate high sensitivity and specificity in distinguishing OCD patients from healthy controls.

The 24th National Conference of Neurology of Chinese Medical Association was held in Zhuhai City, Guangdong Province during September 23-26,2021.The conference adopted a combination of online and offline methods, with a total of 2 plenary meetings, 20 special seminars, 284 invited reports, 382 papers exchanged at the conference and 1 088 papers exchanged on the wall. The conference focused on cerebrovascular diseases, epilepsy, cognitive disorders, myopathy, peripheral neuropathy, neurodegenerative diseases, nerve infectious diseases, demyelinating diseases, neuroimmune diseases, genetic and metabolic nerve diseases, nerve rehabilitation, anxiety and depression, headache, sleep disorders, nerve nursing, nerve intervention, neuroimaging, neuroelectrophysiology, translational medicine, precision medicine and other related nervous system diseases. There were more than 7 000 participants who attended this conferece.