The advent of single-cell transcriptomics marked a paradigm shift in biology, enabling in-depth analysis of cellular heterogeneity and molecular mechanisms at a previously unachievable resolution. Single-cell transcriptomics has revealed previously unrecognized subpopulations, rare cell types, transitional states, and molecular signatures. Many of these novel insights have been successfully translated to therapeutic applications. This review examines the brief history and computational strategies involved in the single-cell transcriptomics technique, as well as the applications of single-cell transcriptomics in musculoskeletal regenerative medicine, focusing on recent discoveries in bone, cartilage, muscle, and tendon biology. Key findings include identification of novel progenitor populations, differentiation pathways, and insights into disease mechanisms. We discuss how single-cell transcriptomics is making breakthroughs in therapeutic strategies through improved understanding of regenerative processes and cellular dynamics.

PURPOSE: The aim of this study was to examine the effects of long-term endurance exercise and natural fermented vinegar on body composition and cardiopulmonary function of 50-aged postmenopausal women. METHODS: Subjects were divided into four groups (sedentary group, aerobic exercise group, natural fermented vinegar group, and aerobic exercise plus natural fermented vinegar group) to perform natural fermented vinegar intake or aerobic exercise for 8 weeks. Body weight, body composition, cardio-pulmonary function test, and blood concentration of glucose, lipid profiles, aspartate aminotransferase, and alanine aminotransferase were measured. RESULTS: The results showed that natural fermented vinegar or aerobic exercise training for 8 weeks no significantly improved body weight control and body composition. However, natural fermented vinegar plus aerobic exercise training for 8 weeks significantly improved cardiopulmonary function. CONCLUSION: These results suggest that natural fermented vinegar plus aerobic exercise training has a significant effect on anti-fatigue.
Acetic Acid* ; Alanine Transaminase ; Aspartate Aminotransferases ; Body Composition* ; Body Weight ; Exercise* ; Fatigue ; Female ; Glucose ; Humans ; Middle Aged* ; Obesity

No abstract available.
Carcinoma, Renal Cell* ; Humans ; Polycystic Kidney, Autosomal Dominant* ; Translocation, Genetic