Depressive disorder is a prevalent psychiatric disorder with complicated pathological mechanism.It has been proved that aseptic inflammation of the central nervous system (CNS) plays an important role in the pathogenesis of depressive disorder. High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein widely presented in eukaryotic nuclei that can induce the central inflammatory response when released into the extracellular space, which in turn participates in the onset of depressive disorder. Therefore, this paper reviewed the researches of HMGB1 in depressive disorder, in order to provide reference for further research.

Depressive disorder is a prevalent psychiatric disorder with complicated pathological mechanism.It has been proved that aseptic inflammation of the central nervous system (CNS) plays an important role in the pathogenesis of depressive disorder. High mobility group box 1 (HMGB1) is a non-histone DNA-binding protein widely presented in eukaryotic nuclei that can induce the central inflammatory response when released into the extracellular space, which in turn participates in the onset of depressive disorder. Therefore, this paper reviewed the researches of HMGB1 in depressive disorder, in order to provide reference for further research.

Objective To study the change pattern of cognition of the ship crew at different stages during prolonged sea deployment,so as to provide scientific evidence for the screening of the ship crew,development of the protocols for the prevention,treatment and improvement of cognition impairment that occurred among the ship crew with a view to reduce the rate of accidents during prolonged deployment at sea.Methods A retrospective study was made on the 185 naval ship personnel who were involved in the 3-month prolonged sea deployment.Detection,comparison,and analysis were performed by using the occupational fatigue scale,the on-line test (A,B) and the continuous performance test (CPT).Results During the 3-month prolonged sea deployment,the fatigue level of the ship crew at day 35 was significantly greater than the fatigue level one week before and after the prolonged deployment,and statistical significance could be seen,when comparisons were made between them (P ＜ 0.05).The length of time spent on the on-line test A and B was longer than that one week before and after the prolonged deployment,and statistical significance could also be seen,when comparisons were made between them (P ＜ 0.05).The accumulated scores of the continuous performance test were all lower than those one week before and after the prolonged deployment,and statistical significance was also noticed,when comparisons were made between them (P ＜ 0.05).Conclusions Prolonged sea deployment could affect such cognitive capabilities as information processing,reasoning,attention and alert of the ship crew.

Objective To study the change pattern of cognition of the ship crew at different stages during prolonged sea deployment,so as to provide scientific evidence for the screening of the ship crew,development of the protocols for the prevention,treatment and improvement of cognition impairment that occurred among the ship crew with a view to reduce the rate of accidents during prolonged deployment at sea.Methods A retrospective study was made on the 185 naval ship personnel who were involved in the 3-month prolonged sea deployment.Detection,comparison,and analysis were performed by using the occupational fatigue scale,the on-line test (A,B) and the continuous performance test (CPT).Results During the 3-month prolonged sea deployment,the fatigue level of the ship crew at day 35 was significantly greater than the fatigue level one week before and after the prolonged deployment,and statistical significance could be seen,when comparisons were made between them (P ＜ 0.05).The length of time spent on the on-line test A and B was longer than that one week before and after the prolonged deployment,and statistical significance could also be seen,when comparisons were made between them (P ＜ 0.05).The accumulated scores of the continuous performance test were all lower than those one week before and after the prolonged deployment,and statistical significance was also noticed,when comparisons were made between them (P ＜ 0.05).Conclusions Prolonged sea deployment could affect such cognitive capabilities as information processing,reasoning,attention and alert of the ship crew.