1.Investigation on the quality standard of pharmaceutical excipient steviol glycosides
Yongfang LI ; Qing YANG ; Cancan DING ; Qiao ZHANG ; Zhizhou JIANG ; Yongfu XIE ; Yuanyuan LI ; Shuai HUANG
Drug Standards of China 2025;26(5):527-532
Objective:To propose suggestions for the revision of quality standard of steviol glycosides through research on its major manufacturer's products.Methods:The inspection items in the current quality standards were inspected,with domestic and international quality standard of steviol glycosides.Results:Specific rotation was from-33.39° to-39.50°,pH was from 5.3 to 6.7,impurity absorbency was lower than 0.096 0,while the contents of weight loss on drying were lower than 5.0%,residue on ignition were lower than 0.043%,methanol residual were lower than 0.01%,ethanol residual were lower than 0.06%,residue on arsenic were lower than 0.000 054%,lead wasn't detected.The content of rebaudioside A and 13 kinds of steviol glycosides were 8.23%-68.48%and 85.78%-96.13%.Conclusion:The main components of the commercial steviol glycosides products were rebaudioside A and stevioside,with low safety risk of elemental impurities and solvent residues.It provided suggestions for the revision of quality standard of steviol glycosides in the Chinese Pharmacopoeia.
2.Investigation on the quality standard of pharmaceutical excipient steviol glycosides
Yongfang LI ; Qing YANG ; Cancan DING ; Qiao ZHANG ; Zhizhou JIANG ; Yongfu XIE ; Yuanyuan LI ; Shuai HUANG
Drug Standards of China 2025;26(5):527-532
Objective:To propose suggestions for the revision of quality standard of steviol glycosides through research on its major manufacturer's products.Methods:The inspection items in the current quality standards were inspected,with domestic and international quality standard of steviol glycosides.Results:Specific rotation was from-33.39° to-39.50°,pH was from 5.3 to 6.7,impurity absorbency was lower than 0.096 0,while the contents of weight loss on drying were lower than 5.0%,residue on ignition were lower than 0.043%,methanol residual were lower than 0.01%,ethanol residual were lower than 0.06%,residue on arsenic were lower than 0.000 054%,lead wasn't detected.The content of rebaudioside A and 13 kinds of steviol glycosides were 8.23%-68.48%and 85.78%-96.13%.Conclusion:The main components of the commercial steviol glycosides products were rebaudioside A and stevioside,with low safety risk of elemental impurities and solvent residues.It provided suggestions for the revision of quality standard of steviol glycosides in the Chinese Pharmacopoeia.
3.Effect of Radix Astragali on the Transmission Small Intestine in Health Subjects
Yongfang QIAO ; Fohu JIANG ; Baoqi KONG
Traditional Chinese Drug Research & Clinical Pharmacology 1993;0(03):-
Objective: To observe the effect of Radix Astragali on the transmission time of small intestine(TTSI).Methods: TTSI and the peak value of lactose absorption were determined by hydrogen breath test in 40 healthy subjects a week before and after administration of Radix Astragali. Results: TTSI was 116.48+ 24.57 min and 102.38+ 13.44 min respectively before and after administration (P 0.05).Conclusion: Oral administration of Radix Astragali for one week has no effect on the absorption of the lactose by small intestine,but can promote the movement of small intestine.

Result Analysis
Print
Save
E-mail