[Objective]To explore CHEN Yongcan's experience in the treatment of metabolic-associated fatty liver disease(MAFLD)combined with the cage theory.[Methods]By following the prescription,collecting clinical medical records,consulting relevant ancient books and literature,this paper expounds CHEN Yongcan's understanding of the cage theory and the MAFLD pathogenesis,summarizes his clinical experience in syndrome differentiation treatment of MAFLD combined with the cage theory and provides medical records for evidence.[Results]CHEN Yongcan believed that the pathogenesis of MAFLD was root deficiency and branch excess,which was similar to the cage theory.The primary deficiency of MAFLD was mainly caused by Qi stagnation,phlegm obstruction and stasis.On the treatment,CHEN Yongcan put forward invigorating spleen to help transportation,nourishing Yin and softening liver to raise origin and consolidate the root,clearing heat and eliminating phlegm,regulating Qi and removing blood stasis to break the cyst,and giving consideration to superficial.The attached test case was liver procomania,with syndrome differentiation of liver depression and spleen deficiency,dampness,heat and blood stasis,with treatment of relieving liver and spleen,clearing heat,dampness and phlegm,regulating Qi and blood circulation and removing blood stasis,and achieved good curative effect.[Conclusion]CHEN Yongcan has rich experiences in differentiation and treatment of MAFLD combined with the cage theory,which is practical and worthy of clinical reference.

[Objective]To explore CHEN Yongcan's experience in the treatment of metabolic-associated fatty liver disease(MAFLD)combined with the cage theory.[Methods]By following the prescription,collecting clinical medical records,consulting relevant ancient books and literature,this paper expounds CHEN Yongcan's understanding of the cage theory and the MAFLD pathogenesis,summarizes his clinical experience in syndrome differentiation treatment of MAFLD combined with the cage theory and provides medical records for evidence.[Results]CHEN Yongcan believed that the pathogenesis of MAFLD was root deficiency and branch excess,which was similar to the cage theory.The primary deficiency of MAFLD was mainly caused by Qi stagnation,phlegm obstruction and stasis.On the treatment,CHEN Yongcan put forward invigorating spleen to help transportation,nourishing Yin and softening liver to raise origin and consolidate the root,clearing heat and eliminating phlegm,regulating Qi and removing blood stasis to break the cyst,and giving consideration to superficial.The attached test case was liver procomania,with syndrome differentiation of liver depression and spleen deficiency,dampness,heat and blood stasis,with treatment of relieving liver and spleen,clearing heat,dampness and phlegm,regulating Qi and blood circulation and removing blood stasis,and achieved good curative effect.[Conclusion]CHEN Yongcan has rich experiences in differentiation and treatment of MAFLD combined with the cage theory,which is practical and worthy of clinical reference.

Beta-thalassemia major(β-TM)is an inherited disease caused by a defect in the synthesis of globin. The disease requires long-term blood transfusion and iron chelator treatment, which can cause various secondary changes in the body and eye tissues. Compared with normal peers, β-TM patients will show changes in the eye such as steeper corneal curvature, shallower anterior chamber, increased lens thickness, shorter axial length, and reduced tear secretion. At the same time, nutritional deficiencies and the use of iron chelator drugs will increase the risk of complicated cataract and retinal degeneration, thus affecting the quality of life of β-TM patients.This article combines relevant domestic and foreign literatures to explore and review the changes in the eye of β-TM patients, with a view to providing valuable insights for clinical practice.

Chronic atrophic gastritis with intestinal metaplasia is a necessary stage for chronic gastritis to develop into gastric cancer.Chen Yongcan believes that the theory of"yang transforming into qi and yin forming shape"can explain the development and diagnosis of chronic atrophic gastritis with intestinal metaplasia.The deficiency of"yang transforming into qi"leads to too much"yin forming shape",which changes the physiological function of the spleen and stomach,and then develops into the pathological process of chronic atrophic gastritis with intestinal metaplasia.Based on the theory of"yang transforming into qi and yin forming shape",the pathogenesis of this disease was briefly analyzed.In clinical treatment,the state of yin and yang was first identified,and the treatment principle of tonifying yang qi to remove yin turbidity was put forward to achieve the purpose of treating both manifestation and root causes.

β thalassemia is a hereditary hemolytic disease caused by the defect of β globin gene. Transfusion-dependent β thalassemia patients need long-term blood transfusion to survive, and a series of systemic and ocular complications will occur in the disease itself and long-term blood transfusion. Retinal blood vessel density decreases, retinal thickness thinned and elastic pseudoxanthoxanoma syndrome are found in fundus due to long-term anemia and side effects of iron chelating agent. At present, there are few reports about eye changes in thalassemia patients, and the cognition is relatively scarce. Therefore, it is necessary to be vigilant for physicians, deeply explore the cause and symptomatic treatment, combined with individual disease characteristics, to provide a more scientific and accurate plan for clinical treatment.

[Objective]To elaborate the clinical experience of CHEN Yongcan,a national expert in traditional Chinese medicine,in the treatment of spleen and stomach diseases,from the perspective of combination of classic prescriptions.[Methods]Select three medical cases from CHEN Yongcan's outpatient clinic that can reflect the characteristics of his active use of traditional Chinese medicine,namely Shengjiang Banxia Decoction combined with Erchen Decoction for treating functional vomiting in children,Dahuang Fuzi Decoction combined with Simo Yinzi for treating stubborn constipation,Taohua Decoction combined with Gegen Qinlian Decoction for treating ulcerative colitis.Provide a detailed introduction for the differentiation and treatment approach,with a focus on the flexible use of the above-mentioned Zhongjing formulas and unique insights into the provisions of the treatise on Shanghan Lun.[Results]Shengjiang Banxia Decoction is mainly used,combined with Erchen Decoction,to better exert its effects of reducing reflux,stopping vomiting,resolving accumulation and stomach problems,thereby quickly solving vomiting in children;The addition of Dahuang Fuzi Decoction to Simo Yinzi has transformed the concept of warming and promoting digestion,breaking through the dilemma of stubborn constipation;Taohua Decoction combined with Gegen Qinlian Decoction treats ulcerative colitis with the direction of clearing dampness heat,detoxifying stagnation and cooling blood heat.The therapeutic effect is satisfactory,and the unique insight that Taohua Decoction is not a warm and astringent agent is proposed.[Conclusion]CHEN Yongcan is adept at using traditional Chinese medicine formulas to treat spleen and stomach diseases,which has positive reference significance for the improvement of the clinical level of traditional Chinese medicine among today's doctors.

[Objective]To elaborate the clinical experience of CHEN Yongcan,a national expert in traditional Chinese medicine,in the treatment of spleen and stomach diseases,from the perspective of combination of classic prescriptions.[Methods]Select three medical cases from CHEN Yongcan's outpatient clinic that can reflect the characteristics of his active use of traditional Chinese medicine,namely Shengjiang Banxia Decoction combined with Erchen Decoction for treating functional vomiting in children,Dahuang Fuzi Decoction combined with Simo Yinzi for treating stubborn constipation,Taohua Decoction combined with Gegen Qinlian Decoction for treating ulcerative colitis.Provide a detailed introduction for the differentiation and treatment approach,with a focus on the flexible use of the above-mentioned Zhongjing formulas and unique insights into the provisions of the treatise on Shanghan Lun.[Results]Shengjiang Banxia Decoction is mainly used,combined with Erchen Decoction,to better exert its effects of reducing reflux,stopping vomiting,resolving accumulation and stomach problems,thereby quickly solving vomiting in children;The addition of Dahuang Fuzi Decoction to Simo Yinzi has transformed the concept of warming and promoting digestion,breaking through the dilemma of stubborn constipation;Taohua Decoction combined with Gegen Qinlian Decoction treats ulcerative colitis with the direction of clearing dampness heat,detoxifying stagnation and cooling blood heat.The therapeutic effect is satisfactory,and the unique insight that Taohua Decoction is not a warm and astringent agent is proposed.[Conclusion]CHEN Yongcan is adept at using traditional Chinese medicine formulas to treat spleen and stomach diseases,which has positive reference significance for the improvement of the clinical level of traditional Chinese medicine among today's doctors.

Objective:To illustrate a relatively complete knowledge system (e.g., research outputs, current hotspots, and future trends) in the sepsis field and to help scholars grasp the scientific research direction or clinical focus of treatment.Methods:The relevant literatures of sepsis during the time from 1985 to 2019 in Web of Science database were collected. Sepsis-related research contents were generated using softwares (CiteSpace 5.6.R2 and VOSviewer 1.6.13), which using data mining, information processing and knowledge map methods, to analyze the historical evolution and predict the development trend.Results:A total of 8 189 papers on sepsis were published. The volume of publications were increasing yearly from 1985 to 2019, and reached the top list of 1 276 in 2019. For research contents of sepsis, it has formed the basic characteristics of sepsis which focusing on epidemiological studies and animal experiments. Through cluster analysis, the researches mainly focused on six aspects: septic rat, necrotizingenterocolitis, sepsis-associated encephalopathy, acute kidney injury (AKI), gut-derived sepsis, and inflammatory mediator. And it presented the literature characteristics that related to the injury or dysfunction of intestines, brain, liver, kidney or other organs, but the heart and lung researches were more marginal. Additionally, based on the top key words with the strongest citation bursts, it reflected that the development trend of the continuous attention hotspots with "endotoxin" or "endotoxin shock", the significant attention hotspots with "inflammation", "immunity" and "multiple organ dysfunction syndrome" (MODS), and the novel burst attention hotspots with sepsis management including "diagnosis" and "chemotherapy".Conclusions:Through the hotspots and trends visualization of sepsis, the current researches are prefer to animal experiments, epidemiology, or other basic scientific aspects. Meanwhile, the researches are mostly focusing on inflammatory reaction, immune function or organ dysfunctions. Integrating the knowledge maps of hotspots and trends, based on researches of epidemiology, diagnosis, risk factors, pathogenesis, or treatment, we predict that the future scientific topics will concentrating on childhood sepsis, organ injury mechanism or intervention relating to MODS, and integrated management of sepsis by combining traditional Chinese medicine and Western medicine.

OBJECTIVE: To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). METHODS: We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak to February 19, 2020. The frequency analysis, cluster analysis and association analysis were performed. RESULTS: The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. The high frequently used herbs were , and . The commonly used traditional formulations included decoction, powder, and decoction. The Chinese patent drugs included pill, injection, and capsule. The most common paired medications were and and Two core combinations and one novel formula were discovered in the study. CONCLUSIONS powder and decoction are the basic formulations for syndrome of COVID-19. In addition, decoction, powder, decoction and decoction are the basic formulations for syndrome of COVID-19. The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. It shows that removing toxicity and eliminating evil are the prescription thought in treating epidemic disease of traditional Chinese medicine.
Betacoronavirus ; isolation & purification ; Coronavirus Infections ; therapy ; Data Mining ; Drugs, Chinese Herbal ; chemistry ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Pandemics ; Pneumonia, Viral ; therapy

OBJECTIVE: To analysis the medication characteristics of the prescriptions issued via open channel by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine in treating coronavirus disease 2019 (COVID-19). METHODS: We collected the data of traditional Chinese medicine related to treatment plans published by the National and Provincial Health Committee and the State Administration of Traditional Chinese Medicine from the start of COVID-19 outbreak in Wuhan to February 19, 2020. The frequency analysis, cluster analysis and correlation analysis were performed. RESULTS: The study collected 4 national and 34 regional prevention and treatment plans, 578 items, 84 traditional Chinese formulations, 60 Chinese patent medicines, and 230 Chinese herbs. The high frequently used herbs were , , , and . The commonly used traditional formulations included Decoction, Powder, and Decoction. The Chinese patent drugs included Pill, Injection, and Capsule. The most common paired medications were and , and . Two core combinations and one novel formula were discovered in the study. CONCLUSIONS Powder and Decoction are the basic formulations for syndrome of COVID-19. In addition, Decoction, Powder, Decoction and Decoction are the basic formulations for syndrome of COVID-19. The main medication characteristics are clearing heat, entilating lung, removing toxicity and removing turbidity. It shows that removing toxicity and eliminating evil are the prescription thought in treating epidemic disease of traditional Chinese medicine.
Betacoronavirus ; Cluster Analysis ; Coronavirus Infections ; therapy ; Data Mining ; Drugs, Chinese Herbal ; analysis ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; statistics & numerical data ; Pandemics ; Pneumonia, Viral ; therapy