Objective To construct an innovative CNN-Transformer dual-stream parallel network architecture integrating clinical data and imaging features for improving the predictive accuracy of pectoralis major myofascial metastasis in breast cancer,and to optimize the model performance by screening the optimal feature subset through genetic algorithm.Methods The proposed architecture concurrently processed clinical records and imaging data,including physical characteristics such as resolution,contrast,grayscale distribution,and texture features to identify their latent correlations.Meanwhile,genetic algorithms were employed to remove redundant features while retaining the most clinically and physically relevant features for pectoralis major myofascial metastasis prediction.Results The CNN-Transformer model that integrated imaging and clinical features showed superior performance across all evaluation metrics such as weighted F1 score and AUCROC,outperforming models relying only on imaging or clinical data.Conclusion The proposed dual-stream parallel network architecture combined with feature selection strategy significantly enhances the predictive accuracy of pectoralis major myofascial metastasis in breast cancer,and demonstrates the critical role of imaging features in improving model performance.

Under the guidance of China′s national innovation-driven development strategy, advancing the deep integration of industry-academia-research in the healthcare sector has become a crucial pathway for enhancing medical technology levels and promoting high-quality development of hospitals. In 2021, Peking University Third Hospital established a hospital-enterprise joint research and development platform centered on hospital leadership, grounded in collaborative innovation theory. By translating the theoretical principles of " goal alignment, resource complementarity, risk sharing, and benefit sharing" into a multidimensional institutional framework, dynamic consensus mechanisms, and specialized support systems, the hospital developed a multi-tiered implementation pathway of " strategic guidance-platform implementation-research and development deployment". This approach enabled precise matching of resources and needs, efficiently advancing the innovation, transformation, and application of medical technologies. By the end of 2024, the platform had established stable partnerships with 22 enterprises, cumulatively undertaken 123 clinical research projects, as well as achieved a series of breakthroughs in fields such as cell therapy and intelligent imaging. This platform could solve problems such as divergent goals and institutional deficiencies in traditional medical enterprise cooperation, which could help to form a good innovation ecosystem and provide reference and inspiration for the construction of China′s medical technology innovation system.

Objective:To explore the effective way to improve the protection efficiency of intellectual property rights of medical institutions in the field of biomedicine by building an efficient patent pre-examination management system, so as to promote the transformation of achievements.Methods:Through literature review, case analysis and combined with the actual examination situation of the intellectual property protection center, the study analyzed and summarized the characteristics of long R&D cycle, rapid technology iteration, multidisciplinary intersection in the field of biomedicine, and the necessity of hospitals to carry out patent pre-examination work.Results:The pre-examination awareness of scientific researchers in medical institutions was weak, the drafting of application documents was not standardized, and the patent achievements were out of touch with the market.Conclusions:To accelerate intellectual property conversion of innovation achievements, innovation management strategies should be implemented: standardized processes, pre-evaluation, professional team support, process control and talent cultivation.

Objective To construct an innovative CNN-Transformer dual-stream parallel network architecture integrating clinical data and imaging features for improving the predictive accuracy of pectoralis major myofascial metastasis in breast cancer,and to optimize the model performance by screening the optimal feature subset through genetic algorithm.Methods The proposed architecture concurrently processed clinical records and imaging data,including physical characteristics such as resolution,contrast,grayscale distribution,and texture features to identify their latent correlations.Meanwhile,genetic algorithms were employed to remove redundant features while retaining the most clinically and physically relevant features for pectoralis major myofascial metastasis prediction.Results The CNN-Transformer model that integrated imaging and clinical features showed superior performance across all evaluation metrics such as weighted F1 score and AUCROC,outperforming models relying only on imaging or clinical data.Conclusion The proposed dual-stream parallel network architecture combined with feature selection strategy significantly enhances the predictive accuracy of pectoralis major myofascial metastasis in breast cancer,and demonstrates the critical role of imaging features in improving model performance.

Under the guidance of China′s national innovation-driven development strategy, advancing the deep integration of industry-academia-research in the healthcare sector has become a crucial pathway for enhancing medical technology levels and promoting high-quality development of hospitals. In 2021, Peking University Third Hospital established a hospital-enterprise joint research and development platform centered on hospital leadership, grounded in collaborative innovation theory. By translating the theoretical principles of " goal alignment, resource complementarity, risk sharing, and benefit sharing" into a multidimensional institutional framework, dynamic consensus mechanisms, and specialized support systems, the hospital developed a multi-tiered implementation pathway of " strategic guidance-platform implementation-research and development deployment". This approach enabled precise matching of resources and needs, efficiently advancing the innovation, transformation, and application of medical technologies. By the end of 2024, the platform had established stable partnerships with 22 enterprises, cumulatively undertaken 123 clinical research projects, as well as achieved a series of breakthroughs in fields such as cell therapy and intelligent imaging. This platform could solve problems such as divergent goals and institutional deficiencies in traditional medical enterprise cooperation, which could help to form a good innovation ecosystem and provide reference and inspiration for the construction of China′s medical technology innovation system.

Objective:To explore the effective way to improve the protection efficiency of intellectual property rights of medical institutions in the field of biomedicine by building an efficient patent pre-examination management system, so as to promote the transformation of achievements.Methods:Through literature review, case analysis and combined with the actual examination situation of the intellectual property protection center, the study analyzed and summarized the characteristics of long R&D cycle, rapid technology iteration, multidisciplinary intersection in the field of biomedicine, and the necessity of hospitals to carry out patent pre-examination work.Results:The pre-examination awareness of scientific researchers in medical institutions was weak, the drafting of application documents was not standardized, and the patent achievements were out of touch with the market.Conclusions:To accelerate intellectual property conversion of innovation achievements, innovation management strategies should be implemented: standardized processes, pre-evaluation, professional team support, process control and talent cultivation.

Objective lo investigate the recovery of urinary function and related influencing factors in patients with stress urinary incontinence(SUI)after the tension-free vaginal tape procedure at the mid-urethra.Methods A total of 112 SUI patients who underwent the tension-free vaginal tape procedure at the mid-urethra in Beijing Rehabilitation Hospital Affiliated to Capital Medical University from October 2018 to October 2023 were selected as the research subjects.The postoperative urinary function recovery of all patients was recorded.According to the postoperative urinary function recovery time,patients with a recovery time of≤3 days were included in the rapid recovery group,and those with a recovery time of＞3 days were included in the non-rapid recovery group.Clinical data including age,body mass index,menopausal status,vaginal delivery history,number of deliveries,disease severity,comorbid hypertension,diabetes,history of pelvic organ prolapse,maximum urinary flow rate,postoperative urinary retention,preoperative bladder residual urine volume,maximum bladder volume,hemoglobin(Hb)level,white blood cell(WBC)count,red blood cell(RBC)count,and platelet(PLT)count of patients between the two groups were compared.Factors affecting the recovery of urinary function in SUI patients were analyzed by multivariate logistic regression.Results The recovery time of urinary function in 112 patients with SUI ranged from 1 to 15(4.10±0.78)days.Specifically,64 patients(57.14％)recovered within 3 days,and 48 patients(42.86％)recovered in more than 3 days.The proportions of patients with menopause,history of vaginal delivery,history of pelvic organ prolapse,and postoperative urinary retention in the non-rapid recovery group were significantly higher than those in the rapid recovery group,and the maximum urinary flow rate was significantly lower than that in the rapid recovery group(P＜0.01).There were no significant differences in age,body mass index,number of deliveries,preoperative bladder residual urine volume,maximum bladder volume,Hb level,WBC count,RBC count,PLT count,disease severity,proportion of patients with comorbid hypertension and proportion of patients with diabetes between the two groups(P＞0.05).Multivariate logistic regression analysis showed that menopause,history of vaginal delivery,history of pelvic organ prolapse,postoperative urinary retention and maximum urinary flow rate were influencing factors for the recovery of urinary function in SUI patients after surgery(P＜0.05).Conclusion The recovery of urinary function in SUI patients after a transvaginal tension-free vaginal tape procedure at mid-urethra is not ideal.Menopause,history of vaginal delivery,history of pelvic organ prolapse,postoperative urinary retention and maximum urinary flow rate are the influencing factors for the recovery of urinary function in SUI patients.

Objectives:To search, evaluate, and summarize the evidence related to the application management of over-the-counter (OTC) medications for constipation in the elderly, providing evidence-based support for the rational use of these medications.Methods:A systematic search was conducted through computerized decision support systems, guideline websites, professional association websites, and databases for clinical decisions, guidelines, evidence summaries, and expert consensus on the management of OTC medications for constipation in the elderly. The search period spanned from January 2018 to March 2023. The quality of the literature was independently assessed, and evidence was extracted. The 2014 version of the Joanna Briggs Institute (JBI) evidence grading system was used to determine the levels of evidence.Results:A total of 18 article were included, consisting of two clinical decisions, five guidelines, seven expert consensus statements, and four evidence summaries. These covered five areas: medication principles for elderly individuals with different characteristics, medication selection, medication monitoring, health education, and precautions, culminating in a total of 30 best evidence.Conclusions:This study summarizes the best evidence for the management of OTC medications for constipation in the elderly, providing evidence-based support for the rational application of these medications.

With the continuous development of science and technology,multidisciplinary cross-fertilization has become an essential driving force to promote scientific and technological innovation.Medical interdisciplinary cooperation not only helps to solve a series of problems in the field of medicine but also promotes the overall improvement of China's medical level and the high-quality development of hospitals.By analyzing the process and bottlenecks of interdisciplinary development in medicine,it introduces the construction of the College Road Alliance led by the Peking University Third Hospital.It summarizes the construction experience of building the essential elements,mechanisms,and institutions of interdisciplinary organizational cooperation.

With the continuous development of science and technology,multidisciplinary cross-fertilization has become an essential driving force to promote scientific and technological innovation.Medical interdisciplinary cooperation not only helps to solve a series of problems in the field of medicine but also promotes the overall improvement of China's medical level and the high-quality development of hospitals.By analyzing the process and bottlenecks of interdisciplinary development in medicine,it introduces the construction of the College Road Alliance led by the Peking University Third Hospital.It summarizes the construction experience of building the essential elements,mechanisms,and institutions of interdisciplinary organizational cooperation.