To investigate the risk factors for acute kidney injury (AKI) following the use of amphotericin B deoxycholate and to develop a predictive model to guide clinical monitoring and intervention.

Objective:To investigate the current status of psychosocial adaptation in young and middle-aged patients after colorectal cancer surgery and to explore its influencing factors, providing a basis for the development of targeted interventions.Methods:A total of 200 postoperative young and middle-aged colorectal cancer patients undergoing follow-up at the outpatient department of Shanxi Cancer Hospital from June 2023 to March 2024 were selected by convenience sampling. Data were collected using a general demographic questionnaire, the Self-Report Psychosocial Adjustment to Illness Scale (PAIS-SR), the Family APGAR Index Questionnaire, and the Simplified Ways of Coping Questionnaire (SWCQ). Multiple linear regression analysis was performed to identify factors influencing psychosocial adaptation.Results:A total of 200 questionnaires were distributed, and 191 valid responses were collected, yielding a valid response rate of 95.5%. The total PAIS-SR score of participants was (57.91±23.45). Multiple linear regression analysis revealed that education level, self-perceived economic status, employment status, presence of a stoma, time since surgery, family care, and positive coping style were statistically significant influencing factors ( P<0.05), explaining 46.4% of the variance in psychosocial adaptation. Conclusions:Healthcare providers should pay particular attention to patients with lower educational levels, poor self-perceived economic conditions, unemployment, a stoma, and shorter postoperative duration. Enhancing family care—starting with patient caregivers—and encouraging the use of positive psychological interventions to foster active coping strategies may help improve psychosocial adaptation in young and middle-aged colorectal cancer patients.

Objective:To investigate the current status of psychosocial adaptation in young and middle-aged patients after colorectal cancer surgery and to explore its influencing factors, providing a basis for the development of targeted interventions.Methods:A total of 200 postoperative young and middle-aged colorectal cancer patients undergoing follow-up at the outpatient department of Shanxi Cancer Hospital from June 2023 to March 2024 were selected by convenience sampling. Data were collected using a general demographic questionnaire, the Self-Report Psychosocial Adjustment to Illness Scale (PAIS-SR), the Family APGAR Index Questionnaire, and the Simplified Ways of Coping Questionnaire (SWCQ). Multiple linear regression analysis was performed to identify factors influencing psychosocial adaptation.Results:A total of 200 questionnaires were distributed, and 191 valid responses were collected, yielding a valid response rate of 95.5%. The total PAIS-SR score of participants was (57.91±23.45). Multiple linear regression analysis revealed that education level, self-perceived economic status, employment status, presence of a stoma, time since surgery, family care, and positive coping style were statistically significant influencing factors ( P<0.05), explaining 46.4% of the variance in psychosocial adaptation. Conclusions:Healthcare providers should pay particular attention to patients with lower educational levels, poor self-perceived economic conditions, unemployment, a stoma, and shorter postoperative duration. Enhancing family care—starting with patient caregivers—and encouraging the use of positive psychological interventions to foster active coping strategies may help improve psychosocial adaptation in young and middle-aged colorectal cancer patients.

Objective:To explore the mediating effect of self-esteem between psychological resilience and social avoidance and distress in colorectal cancer patients.Methods:Totally 210 colorectal cancer patients who visited the outpatient clinic for follow-up at Shanxi Province Cancer Hospital from February to July 2023 were selected by convenience sampling. Data were collected using a general information questionnaire, the Connor-Davidson Resilience Scale (CD-RISC), the Self-Esteem Scale (SES), and the Social Avoidance and Distress Scale (SADS). A total of 210 questionnaires were distributed, with 205 valid responses.Results:The results showed that the total SADS score of colorectal cancer patients was (13.41±6.51), the total SES score was (23.14±5.68), and the total CD-RISC score was (57.27±13.33). Mediating effect analysis indicated that self-esteem partially mediated the relationship between psychological resilience and social avoidance and distress, accounting for 37.08% of the total effect.Conclusions:Colorectal cancer patients exhibit moderate to high levels of social avoidance and distress. Psychological resilience can directly affect patients' social avoidance and distress and can also have an indirect effect through self-esteem. Healthcare providers should implement intervention measures to enhance psychological resilience and self-esteem in colorectal cancer patients, thereby reducing social avoidance and distress and facilitating their reintegration into society.

Sarcopenia, characterized as the progressive decrease in skeletal muscle mass, strength, and function, has been becoming one of chronic musculoskeletal diseases in aging people. In basic research studies, a reliable experimental model would be vital significance for deeply understanding pathophysiological mechanism of sarcopenia and developing novel drugs. This review provided a preliminary summary on the potential mechanisms involved in senescence-induced sarcopenia, followed by a discussion on research progress on pharmacology models based on molecular mechanism of senescence, especially from in vitro cell models and in vivo animal models.

Objective:To analyze the prevalence of anemia and its influencing factors in the elderly population dwelling in urban communities in Beijing.Methods:A random cluster sampling method was adopted to select the elderly people of communities in Beijing, and cross-sectional research was conducted through questionnaire surveys, field tests and blood sample collection.The criteria for diagnosing anemia were from WHO standards, and the health evaluation indicators in the questionnaire survey included demographic data and eating habits, socio-economic information, information on enjoying health services, health and physical fitness and other information.Blood samples were drawn for routine blood tests and biochemical tests.Results:A total of 1 947 elderly people aged 65 years and above were investigated, including 789 males(40.5%)and 1 158 females(59.5%). Among the 1 947 survey subjects, 288 elderly people had anemia, with the prevalence of anemia of 14.79%(288/1 947). The prevalence of anemia was 16.35%(129/789)in males and 13.73%(159/1 158)in females.There was no statistically significant difference in the prevalence of anemia between male and female( χ2=2.760, P=0.097). Logistic regression analysis was used to analyze the factors affecting anemia.The results showed that the higher age( OR=1.055, P=0.000), the higher frequency of meat-eating( OR=1.353, P=0.046), the lower frequency of fruit-eating( OR=0.759, P=0.048), the worse health status of cohabitants( OR=0.757, P=0.037), the lower BMI( OR=0.905, P=0.001)and the lower exercise frequency( OR=0.769, P=0.012)were correlated to the higher anemia risk in the elderly population dwelling in urban communities in Beijing. Conclusions:The prevalence of anemia is relatively high in the elderly in Beijing communities.According to our findings, older people should reduce the frequency of eating meat, while ensuring nutritional intake, increase the intake of fruits and take appropriate exercises to reduce the prevalence of anemia.

Objective To explore the effects of program of pinyin game on children with attention deficit hyperactivity disorder (ADHD) and reading disorder by a randomized controlled trial.Methods Thirty-one cases diagnosed as ADHD according to the criteria of DSM-Ⅳ and comorbid reading disorder were involved in the study.The ADHD and reading disorder children were divided into the intervention group (n=17) and the control group (n=14) by simple random sampling.One of them accepted program of pinyin game training and the other group did not make an intervention.Phonological awareness test,phonetic recognition test and reading ability test were used to evaluate the reading ability of two groups at baseline and the end of week 8,and to make intra-group and inter-group comparisons.Results At baseline,there was no significant difference in reading ability scores between the intervention group and the control group.The scores of the Phoneme deletion (4.9± 1.9 vs.5.9±2.0),Cut pinyin word (37.5(14.0,79.0) vs.50.0(17.0,99.0)),significantly increased after the intervention by the pinyin game learning software in week 8,but there was no significant difference between the two groups(t=-2.248,P=0.043;Z--3.06,P=0.002).Conclusion The intervention effect of the ADHD comorbidity reading disorder group after 8 weeks of program of pinyin game training was not significantly better than that of the control group,but it may improve the children's phonetic awareness and pinyin recognition ability.

Objective To explore the effects of program of pinyin game on children with attention deficit hyperactivity disorder (ADHD) and reading disorder by a randomized controlled trial.Methods Thirty-one cases diagnosed as ADHD according to the criteria of DSM-Ⅳ and comorbid reading disorder were involved in the study.The ADHD and reading disorder children were divided into the intervention group (n=17) and the control group (n=14) by simple random sampling.One of them accepted program of pinyin game training and the other group did not make an intervention.Phonological awareness test,phonetic recognition test and reading ability test were used to evaluate the reading ability of two groups at baseline and the end of week 8,and to make intra-group and inter-group comparisons.Results At baseline,there was no significant difference in reading ability scores between the intervention group and the control group.The scores of the Phoneme deletion (4.9± 1.9 vs.5.9±2.0),Cut pinyin word (37.5(14.0,79.0) vs.50.0(17.0,99.0)),significantly increased after the intervention by the pinyin game learning software in week 8,but there was no significant difference between the two groups(t=-2.248,P=0.043;Z--3.06,P=0.002).Conclusion The intervention effect of the ADHD comorbidity reading disorder group after 8 weeks of program of pinyin game training was not significantly better than that of the control group,but it may improve the children's phonetic awareness and pinyin recognition ability.

Objective To observe the effects of glucagon like peptide-1 (GLP-1) analogues liraglutide on expressions of nitric oxide synthase (NOS) and cyclo-oxygen-ase (COX)2 in renal medulla of type 2 diabetes rats, and the mechanism of its lowering blood pressure and promoting excretion of water and salt in kidney. Methods Type 2 diabetes model rats were generated by high-fat and high-sugar feeding for 8 weeks followed by intraperitoneal injection of streptozotocin (STZ). Subse?quently, eighteen type 2 diabetes rats were divided into two groups: liraglutide treatment group (DMT) and diabetes group (DM). Twelve normal rats were divided into two groups: liraglutide treatment wild type group (WTT) and wild type group (WT). DMT and WTT groups were given liraglutide (200μg/kg) by subcutaneous injection, DM and WT groups were given equivalent normal saline by the same way. The levels of blood glucose and blood pressure were detected at 0, 2, 4 and 6 weeks after treatment in groups of rats. Samples of urine were collected for detecting ion concentrations (K+, Na+and Cl-) af?ter treatment for six weeks. Rats were sacrificed and blood samples were collected for detecting ion concentrations (K+, Na+and Cl-). The expression levels of NOS and COX2 mRNA and protein in renal medulla were detected by real-time PCR and Western blot assay. Results After treating with liraglutide, the values of blood glucose (F=5.933, P<0.05) and blood pres?
sure (F=22.070, P<0.05) were gradually decreased in DMT group. After treatment with liraglutide for 6 weeks, the values of blood glucose (mmol/L:12.78 ± 3.82 vs. 18.75 ± 1.68) and blood pressure (mmHg:119.98 ± 4.43 vs. 136.42 ± 4.48) were signifi?cantly decreased (P<0.05) in DMT group than those of DM group (P<0.05). There were no significant differences in the concentrations of K+, Na+and Cl-between the two groups. There were higher levels of K+(mmol/L:46.55 ± 6.43 vs. 33.13 ± 9.71), Na+(mmol/L:56.33±8.83 vs. 41.20±7.25) and Cl-(mmol/L:159.81±25.06 vs. 71.44±12.99) in urine in DMT group than those of DM group (P<0.05). The mRNA levels and protein expressions of NOS and COX2 in renal medulla were significant?ly increased in DMT group than those of DM group (P<0.05). Conclusion GLP-1 analogues liraglutide may enhance the expression of COX2 by increasing the expression of NOS to excrete water and salt, and decrease blood pressure.

It analyzed the definition, mechanism, characteristics of Mirror Visual Feedback and summarized the application of mirror visual feedback in recovering upper limb function after stroke patients at home and abroad, so as to provide evidences for the further research in China.