Objective To investigate the effects of super early enteral nutrition support on postoperative serum miR-124 levels,inflammatory markers,immune function,nutritional status,and short-term and long-term rehabilitation outcomes in patients with severe traumatic brain injury(STBI).Methods A total of123 STBI patients admitted to our hospital from January 2021 to December 2022 were selected.According to the start time of enteral nutrition,patients were divided into super early enteral nutrition group,late enteral nutrition group and parenteral nutrition group.We collect clinical data from each group and detected serum miR-124 and inflammatory factors,immune indicator,nutritional indicators levels before and after treatment,as well as postoperative complications and prognosis.Results Compared with the parenteral group and the late intestinal group,the levels of miR-124,inflammatory factors and the proportion of CD8+T cells in the super early intestinal group were significantly reduced,while the proportion of CD4+/CD8+cells was significantly increased,with statistical differences(all P＜0.05).Compared with the parenteral group,the levels of albumin,prealbumin,and transferrin in intestinal groups were significantly increased with statistical differences(both P＜0.05).Compared with the late intestinal group,the levels of albumin and prealbumin in the super early intestinal group were significantly increased,with statistical differences(both P＜0.05),while there was no significant difference in transferrin levels between two groups(P＞0.05).There was no significant difference in the incidence of various complications during hospitalization among all groups(all P＞0.05).The total incidence of complications in the super early intestinal group was significantly lower than that in the parenteral group and late intestinal group with statistical differences(both P＜0.05).During the follow-up period,there was no significant difference in prognosis,disability,and mortality among three groups(all P＞0.05).Compared with the parenteral group,the GOS scores of the intestinal groups were significantly reduced with statistical differences(P＜0.05).There was no statistically significant difference in GOS scores between two groups(P＞0.05).Conclusion Super early enteral nutrition support is effective in treating patients with STBI,which can effectively improve the patient's nutritional status,enhance immune function,suppress inflammatory reactions,help repair nerve injuries,and enhance rehabilitation effects.

Objective To investigate the effects of super early enteral nutrition support on postoperative serum miR-124 levels,inflammatory markers,immune function,nutritional status,and short-term and long-term rehabilitation outcomes in patients with severe traumatic brain injury(STBI).Methods A total of123 STBI patients admitted to our hospital from January 2021 to December 2022 were selected.According to the start time of enteral nutrition,patients were divided into super early enteral nutrition group,late enteral nutrition group and parenteral nutrition group.We collect clinical data from each group and detected serum miR-124 and inflammatory factors,immune indicator,nutritional indicators levels before and after treatment,as well as postoperative complications and prognosis.Results Compared with the parenteral group and the late intestinal group,the levels of miR-124,inflammatory factors and the proportion of CD8+T cells in the super early intestinal group were significantly reduced,while the proportion of CD4+/CD8+cells was significantly increased,with statistical differences(all P＜0.05).Compared with the parenteral group,the levels of albumin,prealbumin,and transferrin in intestinal groups were significantly increased with statistical differences(both P＜0.05).Compared with the late intestinal group,the levels of albumin and prealbumin in the super early intestinal group were significantly increased,with statistical differences(both P＜0.05),while there was no significant difference in transferrin levels between two groups(P＞0.05).There was no significant difference in the incidence of various complications during hospitalization among all groups(all P＞0.05).The total incidence of complications in the super early intestinal group was significantly lower than that in the parenteral group and late intestinal group with statistical differences(both P＜0.05).During the follow-up period,there was no significant difference in prognosis,disability,and mortality among three groups(all P＞0.05).Compared with the parenteral group,the GOS scores of the intestinal groups were significantly reduced with statistical differences(P＜0.05).There was no statistically significant difference in GOS scores between two groups(P＞0.05).Conclusion Super early enteral nutrition support is effective in treating patients with STBI,which can effectively improve the patient's nutritional status,enhance immune function,suppress inflammatory reactions,help repair nerve injuries,and enhance rehabilitation effects.

Objective To investigate the relationship between nutritional risk indexes and neurological prognosis in elderly patients with severe craniocerebral injury.Methods A total of 127 elderly patients with severe craniocerebral injury admitted to our hospital from May 2019 to October 2021 were enrolled in this retrospective study.The nutritional risk of the patients was assessed by the prognostic nutritional index(PNI)and nutrition risk in critically ill(NUTRIC)score.Multivariate logistic analysis was used to identify the risk factors affecting the prognosis of neurological function(modified Rankin scale,mRS)at 6 months of onset and a risk model was constructed.Results The patients with PNI<45 had lower Glasgow coma score(GCS)and higher proportions of pulmonary infection and mRS≥3 than the patients with PNI≥45(all P<0.05).The patients with NUTRIC≥5 had lower GCS and higher proportion of mRS≥3 than the patients with NUTRIC<5(all P<0.05).The patients with mRS≥3 were older and had higher proportions of open injury,closed injury,pulmonary infection and subarachnoid hemorrhage,higher NUTRIC score and lower GCS and PNI than the patients with mRS<3(all P<0.05).Age,pulmonary infection,GCS and PNI were risk factors affecting the prognosis of neurological function.The area under the curve(AUC)of the risk model based on the PNI for identifying poor neurological prognosis in elderly patients with severe brain injury was 0.92,with a sensitivity and specificity of 79.5%and 90.7%,respectively.The AUC of the model based on the NUTRIC score was 0.89,with a sensitivity and specificity of 89.0%and 79.6%,respectively.Conclusion Nutritional status assossment based on PNI and NUTRIC score is closely related to the neurological prognosis in patients with severe craniocerebral injury at 6 months after onset.The short-term neurological prognosis is poor in elderly patients with poor nutritional status.

Objective:To study the effects of hyperbaric oxygen (HBO) combined with the intervention of functional position keeping pillow for the hemiplegic hand on the efficacy and motor function of hemiplegic patients after brain injury.Methods:A total of 90 patients with hemiplegia after brain injury treated in Hai’an People’s Hospital from January 2017 to January 2020 were selected as the research subjects and divided into observation group and control group according to the random number table method, with 45 cases in each group. Both groups were given the intervention of functional position keeping pillow for the hemiplegic hand. The observation group was additionally treated with HBO. All patients received two-month treatment. The hand function was evaluated by the Brunnstrom Hand Function Scale and Barthel Index. The severity of pain was evaluated by the visual analogue scale (VAS). The conditions of hand care were evaluated by the hand care scale (including pressure sores, cleanliness, moisture, odor) designed by Hai’an People’s Hospital. The rehabilitation compliance was evaluated by the Posttraumatic Growth Inventory (PTGI) score and the Chinese version of the Connor-Davidson Resilience Scale (CD-RISC).Results:After treatment, the scores of Brunnstrom Hand Function Scale and Barthel Index of the two groups were significantly increased, and the scores of the observation group were significantly higher than those of the control group ( P<0.05); the VAS scores of the two groups were significantly decreased, and the scores of the observation group were significantly lower than those of the control group ( P<0.05); in terms of pressure sores, cleanliness, moisture, odor, and swelling degree, the scores of the observation group were significantly lower than those in the control group ( P<0.05); the scores of PTGI and CD-RISC of the two groups were significantly increased, and the scores of the observation group were significantly higher than those of the control group ( P<0.05). Conclusion:After brain injury, hyperbaric oxygen combined with the intervention of functional position keeping pillow for the hemiplegic hand can significantly improve the motor function of patients.

Objective:To study the effects of hyperbaric oxygen (HBO) combined with the intervention of functional position keeping pillow for the hemiplegic hand on the efficacy and motor function of hemiplegic patients after brain injury.Methods:A total of 90 patients with hemiplegia after brain injury treated in Hai’an People’s Hospital from January 2017 to January 2020 were selected as the research subjects and divided into observation group and control group according to the random number table method, with 45 cases in each group. Both groups were given the intervention of functional position keeping pillow for the hemiplegic hand. The observation group was additionally treated with HBO. All patients received two-month treatment. The hand function was evaluated by the Brunnstrom Hand Function Scale and Barthel Index. The severity of pain was evaluated by the visual analogue scale (VAS). The conditions of hand care were evaluated by the hand care scale (including pressure sores, cleanliness, moisture, odor) designed by Hai’an People’s Hospital. The rehabilitation compliance was evaluated by the Posttraumatic Growth Inventory (PTGI) score and the Chinese version of the Connor-Davidson Resilience Scale (CD-RISC).Results:After treatment, the scores of Brunnstrom Hand Function Scale and Barthel Index of the two groups were significantly increased, and the scores of the observation group were significantly higher than those of the control group ( P<0.05); the VAS scores of the two groups were significantly decreased, and the scores of the observation group were significantly lower than those of the control group ( P<0.05); in terms of pressure sores, cleanliness, moisture, odor, and swelling degree, the scores of the observation group were significantly lower than those in the control group ( P<0.05); the scores of PTGI and CD-RISC of the two groups were significantly increased, and the scores of the observation group were significantly higher than those of the control group ( P<0.05). Conclusion:After brain injury, hyperbaric oxygen combined with the intervention of functional position keeping pillow for the hemiplegic hand can significantly improve the motor function of patients.

Objective To investigate the efficacy of hyperbaric oxygen ( HBO ) combined with ganglioside on diffuse axonal injury and effects on serum-related indicators and prognosis. Methods Eighty-two patients with diffuse axonal injury admitted into our department were equally divided into 2 groups ( n=41 ) , according to different treatment methods. The control group was given such symptomatic supportive treatment as hormone, hemostasis, reduction of intracranial pressure via dehydration, nerve nutrition, maintenance of electrolyte balance, fluid infusion and routine nursing care. The study group was treated with HBO therapy combined with ganglioside in addition to the treatment received by the control group. The rate of consciousness and mean conscious recovery time, serum-related indicators, cognitive function and prognosis after treatment were compared between the patients of the 2 groups. Results After treatment, the rate of consciousness (80. 5％) and mean conscious recovery time of the study group ( 9. 3 ± 1. 4days ) were all superior to (56. 1％)and (16. 1 ± 3. 3 days) of the control group (χ2 =5. 632, t=6. 349, P<0. 05). After treatment, the levels of neuron-specific enolase (NSE) (11. 1 ± 2. 3 μg/L), S100 calcium binding protein B (S100B) (1. 1 ± 0. 1 ng/L) and myelin basic protein (MBP) (6. 6 ± 1. 2μg/L) were all significantly better than (16. 7 ±3.1)μg/L,(1.6±0.2)ng/L and(8.5 ±1.0)μg/L of the control group (t1 =4.684, t2 =5.219, t3 =4. 352, P<0. 05). Following treatment, the MMSE scores (28. 3 ± 5. 3) and ADL scores (25. 1 ± 1. 1) of the study group were significantly better than the MMSE scores (25. 2 ± 4. 1) and ADL scores (33. 6 ± 1. 5) of the control group (t1 =4. 429, t2 =5. 642, P<0. 05). Six months after treatment, the prognosis rate of the study group (73. 2％) was significantly higher than that of the control group (41. 5％) (χ2 =8. 424, P<0. 05). Conclusion HBO combined with ganglioside could produce better therapeutic effects in the treatment of diffuse axonal injury. In the meantime, it could avoid deterioration of secondary brain injury to the largest extent and promote recovery of nerve function, and ultimately improve the prognosis of patients. For this reason, it is worth further clinical application.

Objective To investigate the efficacy of hyperbaric oxygen ( HBO ) combined with ganglioside on diffuse axonal injury and effects on serum-related indicators and prognosis. Methods Eighty-two patients with diffuse axonal injury admitted into our department were equally divided into 2 groups ( n=41 ) , according to different treatment methods. The control group was given such symptomatic supportive treatment as hormone, hemostasis, reduction of intracranial pressure via dehydration, nerve nutrition, maintenance of electrolyte balance, fluid infusion and routine nursing care. The study group was treated with HBO therapy combined with ganglioside in addition to the treatment received by the control group. The rate of consciousness and mean conscious recovery time, serum-related indicators, cognitive function and prognosis after treatment were compared between the patients of the 2 groups. Results After treatment, the rate of consciousness (80. 5％) and mean conscious recovery time of the study group ( 9. 3 ± 1. 4days ) were all superior to (56. 1％)and (16. 1 ± 3. 3 days) of the control group (χ2 =5. 632, t=6. 349, P<0. 05). After treatment, the levels of neuron-specific enolase (NSE) (11. 1 ± 2. 3 μg/L), S100 calcium binding protein B (S100B) (1. 1 ± 0. 1 ng/L) and myelin basic protein (MBP) (6. 6 ± 1. 2μg/L) were all significantly better than (16. 7 ±3.1)μg/L,(1.6±0.2)ng/L and(8.5 ±1.0)μg/L of the control group (t1 =4.684, t2 =5.219, t3 =4. 352, P<0. 05). Following treatment, the MMSE scores (28. 3 ± 5. 3) and ADL scores (25. 1 ± 1. 1) of the study group were significantly better than the MMSE scores (25. 2 ± 4. 1) and ADL scores (33. 6 ± 1. 5) of the control group (t1 =4. 429, t2 =5. 642, P<0. 05). Six months after treatment, the prognosis rate of the study group (73. 2％) was significantly higher than that of the control group (41. 5％) (χ2 =8. 424, P<0. 05). Conclusion HBO combined with ganglioside could produce better therapeutic effects in the treatment of diffuse axonal injury. In the meantime, it could avoid deterioration of secondary brain injury to the largest extent and promote recovery of nerve function, and ultimately improve the prognosis of patients. For this reason, it is worth further clinical application.