Objective:To investigate the clinical feature of psoriatic arthritis (PsA) and serum negative rheumatoid arthritis (SNRA).Methods:A retrospective analysis was conducted on 77 patients with PsA who visited the Rheumatology and Immunology Department of the Second Affiliated Hospital of Wannan Medical College and the Yijishan Hospital of Wannan Medical College from October 2020 to October 2023 as the observation group. A total of 87 patients with SNRA who visited during the same period were collected as the control group. The clinical characteristics, laboratory indicators, joint magnetic resonance imaging, and extra articular manifestations of the two groups of patients were compared. The Kolmogorov-Smirnov test was used to determine whether the metric data conforms to normal distribution. The group differences of non-normal distribution of measurement data were analyzed by Mann-Whitney U test .Chi square or continuity corrected chi square analysis were used to compare rates or composition ratios. Results:The male to female incidence ratio in the PsA group was 4∶3, while in the SNRA group it was 6∶23. There were more male patients in the PsA group( χ2=21.56, P<0.001). The average age of the PsA group was (50±11) years, which was lower than that of the SNRA group (57±13) years ( t=3.84, P=0.001). The incidence of distal interphalangeal joint swelling and pain in the PsA group was 57.1%(44/77), which was higher than that in the SNRA group (9.2%, 8/87) ( χ2=43.37, P<0.001). The incidence of distal interphalangeal joint swelling and pain in the PsA group was 62.3%(48/77), which was higher than that in the SNRA group (5.7%, 5/87) ( χ2=59.81, P<0.001). The incidence of axial joint involvement in the PsA group was 28.6%(22/77), which was higher than that in the SNRA group (4.6%, 4/87) ( χ2=31.68, P<0.001). The intensity of tenosynovitis in the PsA group was 2.00 (1.00, 2.00), which was higher than that in the SNRA group 0.00(0.00, 1.00) ( Z=-2.25, P=0.047). The wrist joint bone erosion intensity in the PsA group was 5.00 (4.00, 8.00), which was higher than that in the SNRA group by 2.50 (1.00, 5.00) ( Z=-2.59, P=0.010). The intensity of wrist tenosynovitis in the PsA group was 1.00 (0.00, 1.00), which was lower than that in the SNRA group by 1.50(1.00, 2.00) ( Z=-2.61, P=0.009). The intensity of knee joint tenosynovitis in the PsA group was 0.00(0.00, 0.00), lower than that in the SNRA group by 1.00 (1.00, 2.00) ( Z=-3.98, P<0.001). The intensity of knee joint bone erosion in the PsA group was 0.00(0.00, 2.25), lower than that in the SNRA group by 1.00 (1.00, 2.50) ( Z=-2.70, P=0.007). The incidence of soft tissue edema around the knee joint in the PsA group was 85.7%(12/14), higher than that in the SNRA group by 45.0%(9/12) ( χ2=5.78, P=0.016). The incidence rate of EAMs in PsA group was 18.8%(6/32), significantly lower than that in SNRA group 67.6%(23/34) ( χ2=16.00, P<0.001). Conclusion:Compared with SNRA, PSA patients are mostly male, with a lower age of onset, often involving the axial joint and distal interphalangeal joint. Foot tenosynovitis is more severe, wrist joint bone erosion is higher, soft tissue edema around the knee joint is more common, and extraarticular manifestations are less common.

Objective:To investigate the clinical feature of psoriatic arthritis (PsA) and serum negative rheumatoid arthritis (SNRA).Methods:A retrospective analysis was conducted on 77 patients with PsA who visited the Rheumatology and Immunology Department of the Second Affiliated Hospital of Wannan Medical College and the Yijishan Hospital of Wannan Medical College from October 2020 to October 2023 as the observation group. A total of 87 patients with SNRA who visited during the same period were collected as the control group. The clinical characteristics, laboratory indicators, joint magnetic resonance imaging, and extra articular manifestations of the two groups of patients were compared. The Kolmogorov-Smirnov test was used to determine whether the metric data conforms to normal distribution. The group differences of non-normal distribution of measurement data were analyzed by Mann-Whitney U test .Chi square or continuity corrected chi square analysis were used to compare rates or composition ratios. Results:The male to female incidence ratio in the PsA group was 4∶3, while in the SNRA group it was 6∶23. There were more male patients in the PsA group( χ2=21.56, P<0.001). The average age of the PsA group was (50±11) years, which was lower than that of the SNRA group (57±13) years ( t=3.84, P=0.001). The incidence of distal interphalangeal joint swelling and pain in the PsA group was 57.1%(44/77), which was higher than that in the SNRA group (9.2%, 8/87) ( χ2=43.37, P<0.001). The incidence of distal interphalangeal joint swelling and pain in the PsA group was 62.3%(48/77), which was higher than that in the SNRA group (5.7%, 5/87) ( χ2=59.81, P<0.001). The incidence of axial joint involvement in the PsA group was 28.6%(22/77), which was higher than that in the SNRA group (4.6%, 4/87) ( χ2=31.68, P<0.001). The intensity of tenosynovitis in the PsA group was 2.00 (1.00, 2.00), which was higher than that in the SNRA group 0.00(0.00, 1.00) ( Z=-2.25, P=0.047). The wrist joint bone erosion intensity in the PsA group was 5.00 (4.00, 8.00), which was higher than that in the SNRA group by 2.50 (1.00, 5.00) ( Z=-2.59, P=0.010). The intensity of wrist tenosynovitis in the PsA group was 1.00 (0.00, 1.00), which was lower than that in the SNRA group by 1.50(1.00, 2.00) ( Z=-2.61, P=0.009). The intensity of knee joint tenosynovitis in the PsA group was 0.00(0.00, 0.00), lower than that in the SNRA group by 1.00 (1.00, 2.00) ( Z=-3.98, P<0.001). The intensity of knee joint bone erosion in the PsA group was 0.00(0.00, 2.25), lower than that in the SNRA group by 1.00 (1.00, 2.50) ( Z=-2.70, P=0.007). The incidence of soft tissue edema around the knee joint in the PsA group was 85.7%(12/14), higher than that in the SNRA group by 45.0%(9/12) ( χ2=5.78, P=0.016). The incidence rate of EAMs in PsA group was 18.8%(6/32), significantly lower than that in SNRA group 67.6%(23/34) ( χ2=16.00, P<0.001). Conclusion:Compared with SNRA, PSA patients are mostly male, with a lower age of onset, often involving the axial joint and distal interphalangeal joint. Foot tenosynovitis is more severe, wrist joint bone erosion is higher, soft tissue edema around the knee joint is more common, and extraarticular manifestations are less common.

Objective:To systematic review the clinical efficacy and safety of neoadjuvant chemotherapy and neoadjuvant concurrent chemoradiotherapy for resectable esophageal squamous cell carcinoma.Methods:Literature search was performed from Web of Science, Pubmed, Cochrane Library, Embase, CBM, Wanfang Data, CNKI and Chongqing VIP. The clinical controlled studies of neoadjuvant chemotherapy versus neoadjuvant concurrent chemoradiation in the treatment of resectable esophageal squamous cell carcinoma was searched. Relevant outcome indicators were analyzed by Revman 5.3 statistical software.Results:Nine studies were included, with a total of 1, 369 patients. Compared with the neoadjuvant chemoradiotherapy, the neoadjuvant chemotherapy had lower overall survival rates at 3 and 5 years( OR=0.68, 95% CI: 0.53-0.86, P<0.05; OR=0.51, 95% CI: 0.34-0.77, P<0.05) , lower pathological complete remission rate( OR=0.28, 95% CI: 0.18-0.45, P<0.05)and R0 resection rate( OR=0.39, 95% CI: 0.22-0.68, P<0.05), The total postoperative complication rate is similar( OR=1.07, 95% CI: 0.75-1.51, P>0.05). Conclusion:Neoadjuvant concurrent radiochemotherapy maybe superior to neoadjuvant chemotherapy among patients with resectable esophageal squamous cell carcinoma.