The gut microbiome actively regulates host immunity,digestive processes,and the function of the intesti-nal endocrine system.Additionally,it modulates host neural signal transmission and nutrient metabolism through metabo-lite generation.Vascular calcification involves the deposition of calcium phosphate in blood vessel walls,secondary to metabolic disorders such as chronic kidney disease,atherosclerosis,diabetes,and osteoporosis.Recent research spanning the past two decades has indicated a close correlation between shifts in the composition and functionality of the gut microbiota,along with its metabolites,and the onset of metabolic disease-related vascular calcification.This paper pres-ents a comprehensive review of the roles and mechanisms of the gut microbiota in this context.

The gut microbiome actively regulates host immunity,digestive processes,and the function of the intesti-nal endocrine system.Additionally,it modulates host neural signal transmission and nutrient metabolism through metabo-lite generation.Vascular calcification involves the deposition of calcium phosphate in blood vessel walls,secondary to metabolic disorders such as chronic kidney disease,atherosclerosis,diabetes,and osteoporosis.Recent research spanning the past two decades has indicated a close correlation between shifts in the composition and functionality of the gut microbiota,along with its metabolites,and the onset of metabolic disease-related vascular calcification.This paper pres-ents a comprehensive review of the roles and mechanisms of the gut microbiota in this context.