Mammalian reproduction is closely related to their metabolic status. The hypothalamus-pituitary-gonad axis ( HPG axis) is regulated by various metabolic factors. Glucagon-like peptide-1 ( GLP-1) is one of various metabolic factors that not only affect glycemic and metabolic control, but also with many other effects, including affecting HPA axis. The function of GLP-1 is related to the location of glucagon-like peptide-1 receptor ( GLP-1R) distribution. It has been confirmed that GLP-1R is widely distributed in HPG axis. The effects of GLP-1 and GLP-1R agonists on the HPG axis have also attracted much attention. The positive effects of GLP-1 and GLP-1R agonists on the HPG axis indicated it could be the new target for the new treatment for gonadal diseases. The role of GLP-1 and GLP-1R agonists in the central nervous system is reviewed.

The low expression of microRNA-335 (miR-335) indicates poor prognosis in many types of cancer,such as gastric cancer,breast cancer,lung cancer and other solid tumors.The low expression of miR-335 can promote tumor metastasis and progression,and is associated with histological grading,lymph node metastasis and tumor staging,which provids a new way of thinking for the diagnosis and treatment of tumors.