Objective:To explore the effects of hyperbaric oxygen (HBO) on inflammation and oxidative stress level in rats with cerebral atherosclerosis.Methods:A total of 30 six-week-old male Sprague Dawley (SD) rats, after being fed for one week, were divided into control group, model group, and HBO group with 10 rats in each group, according to random number table method. The rats in the model group and the HBO group were fed with a high-fat diet combined with L-nitro-arginine methyl ester (L-NAME). Those in the HBO group received HBO treatment. After treatment, all the rats’ serum was collected to assess the levels of blood lipid, inflammation factors, and oxidative stress. Results:After 30 days of treatment, the infiltration degree of inflammatory cells in brain tissues of the HBO group significantly decreased. Compared with the control group, the serum levels of triglyceride (TG), total cholesterol (TC), and atherosclerosis index (AI) in the model group significantly increased, while high-density lipoprotein-cholesterol (HDL-C) significantly decreased ( P<0.01). Compared with the model group, the serum levels of TG, TC, and AI in the HBO group significantly decreased, while HDL-C significantly increased ( P<0.05). Compared with the control group, the serum levels of pro-inflammatory factors including TNF-α, IL-1β, and IL-6 in the model group significantly increased, while anti-inflammatory factor IL-10 significantly decreased ( P<0.01). Compared with the model group, the levels of TNF-α, IL-1β, and IL-6 in HBO group significantly decreased, while IL-10 significantly increased ( P<0.05). Compared with the control group, the serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the model group significantly decreased, while malondialdehyde (MDA) significantly increased ( P<0.01). After HBO treatment, SOD and GSH-Px levels significantly increased, while MDA significantly decreased ( P<0.05). Conclusion:HBO treatment can improve the level of blood lipid and inhibit oxidative stress and inflammatory response in rats with cerebral atherosclerosis.

Objective:To explore the effects of hyperbaric oxygen (HBO) on inflammation and oxidative stress level in rats with cerebral atherosclerosis.Methods:A total of 30 six-week-old male Sprague Dawley (SD) rats, after being fed for one week, were divided into control group, model group, and HBO group with 10 rats in each group, according to random number table method. The rats in the model group and the HBO group were fed with a high-fat diet combined with L-nitro-arginine methyl ester (L-NAME). Those in the HBO group received HBO treatment. After treatment, all the rats’ serum was collected to assess the levels of blood lipid, inflammation factors, and oxidative stress. Results:After 30 days of treatment, the infiltration degree of inflammatory cells in brain tissues of the HBO group significantly decreased. Compared with the control group, the serum levels of triglyceride (TG), total cholesterol (TC), and atherosclerosis index (AI) in the model group significantly increased, while high-density lipoprotein-cholesterol (HDL-C) significantly decreased ( P<0.01). Compared with the model group, the serum levels of TG, TC, and AI in the HBO group significantly decreased, while HDL-C significantly increased ( P<0.05). Compared with the control group, the serum levels of pro-inflammatory factors including TNF-α, IL-1β, and IL-6 in the model group significantly increased, while anti-inflammatory factor IL-10 significantly decreased ( P<0.01). Compared with the model group, the levels of TNF-α, IL-1β, and IL-6 in HBO group significantly decreased, while IL-10 significantly increased ( P<0.05). Compared with the control group, the serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the model group significantly decreased, while malondialdehyde (MDA) significantly increased ( P<0.01). After HBO treatment, SOD and GSH-Px levels significantly increased, while MDA significantly decreased ( P<0.05). Conclusion:HBO treatment can improve the level of blood lipid and inhibit oxidative stress and inflammatory response in rats with cerebral atherosclerosis.

Objective To investigate the effect of statin pretreatment on collateral circulation and prognoses of patients with cardiac large artery occlusive stroke.MethodsFifty-three patients with cardiac large artery occlusive stroke admitted to our hospital from January 2016 to July 2019 were selected. All patients had unilateral middle cerebral artery occlusion. DSA was used to evaluate the collateral flows, and the differences of collateral flows and prognoses in patients took statins before onset were compared with those did not take statins.ResultsAs compared with patients did not take statins, patients took statins had higher incidences of diabetes and coronary heart disease, lower content of low density cholesterol, higher proportion of patients with good collateral circulation (grading 3 to 4), and lower modified Rankin scale scores 3 months after surgery, with statistically significant differences (P< 0.05). Multivariate Logistic regression analysis showed that percentage of patients took statins was independent factors affecting collateral flow in patients with cardiac arterial occlusive stroke(OR=5.000, 95％CI: 1.136-22.006,P=0.033).ConclusionIn patients with cardiac large artery occlusive stroke, statin pretreatment could improve collateral flow and clinical prognoses.