BackgroundMobile phone addiction among college students seriously impairs their physical and psychological health and has garnered growing social concern. Although both social anxiety and alienation are closely associated with mobile phone addiction， the mediating role of alienation in the relationship between social anxiety and mobile phone addiction， as well as its various dimensions， remains insufficiently explored. ObjectiveTo investigate the influence of social anxiety on mobile phone addiction and its dimensions among college students， and to examine the mediating role of alienation， thereby providing references for the prevention and intervention in mobile phone addiction in this population. MethodsIn June 2024， a cluster random sampling method was employed to select 850 college students from two universities in Heilongjiang Province. Participants completed the Interaction Anxiousness Scale （IAS）， the Mobile Phone Addiction Index （MPAI）， and the Adolescent Students' Alienation Scale （ASAS）. Spearman correlation analysis was conducted to examine the correlation between the scores on each scale. Mediation analysis examining the role of alienation in the relationship between social anxiety and mobile phone addiction including its dimensions were conducted using model 4 of the process macro version 3.3 in SPSS. ResultsA total of 796 valid questionnaires were recovered， yielding an effective response rate of 93.65%. The IAS total score was positively correlated with MPAI total score and all its subscale scores including loss of control， withdrawal， avoidance， and inefficiency （r=0.303， 0.207， 0.237， 0.208， 0.340， P<0.01）. The ASAS total score also showed positive correlations with the MPAI score and its subscales （r=0.506， 0.394， 0.439， 0.343， 0.470， P<0.01）. Additionally， the IAS total score was positively correlated with ASAS total score （r=0.461， P<0.01）. Alienation played a mediating role between social anxiety and mobile phone addiction as well as its subscales， with indirect effects of 0.215 （95% CI： 0.167–0.266）， 0.189 （95% CI： 0.147–0.239）， 0.161 （95% CI： 0.119–0.206）， 0.145 （95% CI： 0.103–0.191）， and 0.194 （95% CI： 0.149–0.242）， accounting for 76.51%， 82.17%， 87.98%， 74.36%， and 60.25% of the total effects， respectively. ConclusionSocial anxiety among college students not only exerts a direct effect on mobile phone addiction and its dimensions， but also indirectly influences them through the mediating role of alienation. ［Funded by Youth Project of Heilongjiang Province Philosophy and Social Sciences Research Planning （number， 25SHC011）； Teaching Research Project of Heilongjiang University of Science and Technology in 2025 （number， JY25-27）］

Coronavirus is the largest RNA virus with known genome so far,among which porcine coronavirus is an important pathogen causing acute diarrhea in piglets.Due to its highly mutable RNA nature,this virus poses a substantial challenge for disease prevention and control,leading to substantial annual economic losses within China's swine industry.The analysis of the mechanism of RNA synthesis of coronaviruses is helpful for understanding the genetic variation of coronaviruses and screening antiviral drugs.At present,more in-depth studies mainly focus on Murine coronavir-us(MHV)and human Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).In order to investigate the replication mechanism of porcine coronaviruses,this article takes MHV,SARS-CoV-2 and other coronaviruses as references to summarises the mechanism of regulating viral rep-lication in the non-coding region of porcine coronaviruses such as Porcine epidemic diarrhea virus(PEDV),Transmissible gastroenteritis virus(TGEV),Porcine deltacoronavirus(PDCoV),and Swine acute diarrhea syndrome coronavirus(SADS-CoV).Placed a specific emphasis on the func-tional roles of conserved motifs and secondary structures within the 5'UTR in facilitating viral rep-lication,elucidated how conserved structures in the 3'UTR regulate the same process.The signifi-cance of the interaction between the non-coding region of the virus and the host were discussed,and variations in the viral 5'UTR and 3'UTR were scrutinized,thereby establishing a solid theoret-ical foundation for the development of antiviral drugs that target UTRs and high titer vaccine can-didate strains.

Coronavirus is the largest RNA virus with known genome so far,among which porcine coronavirus is an important pathogen causing acute diarrhea in piglets.Due to its highly mutable RNA nature,this virus poses a substantial challenge for disease prevention and control,leading to substantial annual economic losses within China's swine industry.The analysis of the mechanism of RNA synthesis of coronaviruses is helpful for understanding the genetic variation of coronaviruses and screening antiviral drugs.At present,more in-depth studies mainly focus on Murine coronavir-us(MHV)and human Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).In order to investigate the replication mechanism of porcine coronaviruses,this article takes MHV,SARS-CoV-2 and other coronaviruses as references to summarises the mechanism of regulating viral rep-lication in the non-coding region of porcine coronaviruses such as Porcine epidemic diarrhea virus(PEDV),Transmissible gastroenteritis virus(TGEV),Porcine deltacoronavirus(PDCoV),and Swine acute diarrhea syndrome coronavirus(SADS-CoV).Placed a specific emphasis on the func-tional roles of conserved motifs and secondary structures within the 5'UTR in facilitating viral rep-lication,elucidated how conserved structures in the 3'UTR regulate the same process.The signifi-cance of the interaction between the non-coding region of the virus and the host were discussed,and variations in the viral 5'UTR and 3'UTR were scrutinized,thereby establishing a solid theoret-ical foundation for the development of antiviral drugs that target UTRs and high titer vaccine can-didate strains.

Coronary artery calcifications (CAC) is an independent risk factor for cardiovascular disease (CVD). It has been revealed that this condition can be automatically quantified through computerize tomographic (CT) scan contained in radiotherapy plan for patients with breast cancer, with which, physicians can identify the patients with increased risk of CVD after radiotherapy prematurely and take intervention measures in advance. In this article, the current literature and research progress on the correlation between CAC and cardiotoxicity in patients with breast cancer after radiotherapy were reviewed, expecting to provide a strategy to reduce the CVD risk in patients with breast cancer after radiotherapy.

BACKGROUND:High liquid-absorbing property, high-capacity imbibition property and high antibacterial property of chitosan dressings can be promoted by chemical modification.
OBJECTIVE:To observe the effect of high-absorbing chitosan dressings on hemostasis and wound healing.
METHODS: (1) Venule bleeding experiment: symmetry oozing wounds were produced on the rabbit skin, which were respectively covered by high-absorbing chitosan dressings and sterile gauze. Then, hemostatic time and bleeding volume were recorded. (2) Deep II degree burn wound healing experiment: 40 Sprague-Dawley rats were selected to prepare deep II degree burn wounds on the back, and then model rats were randomly divided into two groups: experimental group with high-absorbing chitosan dressings and control group with vaseline gauze. After 3, 7, 14, 21 days, wound tissues were taken and analyzed histopathologicaly.
RESULTS AND CONCLUSION: (1) Venule bleeding experiment: The bleeding amount and hemostatic time were significantly lower in the high-absorbing chitosan dressing group than the sterile gauze group (P < 0.05,P < 0.01). (2) Deep II degree burn wound healing experiment: the unhealed wound areas were significantly lower in the experimental group than the control group at days 7, 14, 21 after repair (P < 0.05). After 3 days of wound repair, necrosis of the squamous epithelial layer and the structural damage of the hair folicle in the corium layer and skin appendages were found in both two groups. Meanwhile, the infiltration caused by varying numbers of neutrophils and lymphocytes inside the damaged skin tissues was visible. After 21 days of repair, the epithelium healed wel in the control group, with a little lymphocyte infiltration and formation of crust on the skin surface; while in the experimental group, the epithelium healed wel, with complete squamous epithelial layer and no inflammatory cel infiltration. Thus, these experimental findings reveal that the high-absorbing chitosan dressing has an excelent effect on hemostasis and wound healing.