BackgroundMobile phone addiction among college students seriously impairs their physical and psychological health and has garnered growing social concern. Although both social anxiety and alienation are closely associated with mobile phone addiction， the mediating role of alienation in the relationship between social anxiety and mobile phone addiction， as well as its various dimensions， remains insufficiently explored. ObjectiveTo investigate the influence of social anxiety on mobile phone addiction and its dimensions among college students， and to examine the mediating role of alienation， thereby providing references for the prevention and intervention in mobile phone addiction in this population. MethodsIn June 2024， a cluster random sampling method was employed to select 850 college students from two universities in Heilongjiang Province. Participants completed the Interaction Anxiousness Scale （IAS）， the Mobile Phone Addiction Index （MPAI）， and the Adolescent Students' Alienation Scale （ASAS）. Spearman correlation analysis was conducted to examine the correlation between the scores on each scale. Mediation analysis examining the role of alienation in the relationship between social anxiety and mobile phone addiction including its dimensions were conducted using model 4 of the process macro version 3.3 in SPSS. ResultsA total of 796 valid questionnaires were recovered， yielding an effective response rate of 93.65%. The IAS total score was positively correlated with MPAI total score and all its subscale scores including loss of control， withdrawal， avoidance， and inefficiency （r=0.303， 0.207， 0.237， 0.208， 0.340， P<0.01）. The ASAS total score also showed positive correlations with the MPAI score and its subscales （r=0.506， 0.394， 0.439， 0.343， 0.470， P<0.01）. Additionally， the IAS total score was positively correlated with ASAS total score （r=0.461， P<0.01）. Alienation played a mediating role between social anxiety and mobile phone addiction as well as its subscales， with indirect effects of 0.215 （95% CI： 0.167–0.266）， 0.189 （95% CI： 0.147–0.239）， 0.161 （95% CI： 0.119–0.206）， 0.145 （95% CI： 0.103–0.191）， and 0.194 （95% CI： 0.149–0.242）， accounting for 76.51%， 82.17%， 87.98%， 74.36%， and 60.25% of the total effects， respectively. ConclusionSocial anxiety among college students not only exerts a direct effect on mobile phone addiction and its dimensions， but also indirectly influences them through the mediating role of alienation. ［Funded by Youth Project of Heilongjiang Province Philosophy and Social Sciences Research Planning （number， 25SHC011）； Teaching Research Project of Heilongjiang University of Science and Technology in 2025 （number， JY25-27）］

OBJECTIVE To study the in vitro transdermal characteristics of Tibetan new drugs hereinafter referred to as Zhengrutie cataplasm, and to evaluate the safety of skin medication by using different species of animals(guinea pigs, New Zealand rabbits). METHODS The improved vertical Franz diffusion cell method was used for in vitro transdermal testand the skin of Bama miniature pig was used as the permeation barrier. The cumulative permeation amount and rate of geniposide methyl ester and 8-O-acetyl geniposide methyl ester, borneol and camphor in the receiving medium were determined by HPLC and GC, respectively, to investigate the in vitro transdermal characteristics of Zhengrutie cataplasm. Buehler test was used to study the sensitization of Zhengrutie cataplasm on guinea pig skin. Observed the skin irritation after single or multiple application of Zhengrutie cataplasm on intact and damaged skin of New Zealand rabbits. RESULTS The cumulative permeation amount of the sum of geniposide methyl ester and 8-O-acetyl geniposide methyl ester, borneol and camphor within 24 h were 14.14, 348.21, 490.97 μg·cm-2, respectively. The cumulative permeation amount were 6.2%, 10.2% and 15.3%, respectively. The average permeation amount were 0.59, 14.51 and 20.46 μg·cm-2·h-1. No allergic reaction to guinea pig skin, no irritation to intact skin of New Zealand rabbits, mild irritation to damaged skin. CONCLUSION The in vitro transdermal performance of Zhengrutie cataplasm is good. The in vitro transdermal process conforms to the zero-order kinetic equation. It has no irritation and sensitization effect on the skin of guinea pigs and New Zealand rabbits. It is safe and reliable for skin external use and has good clinical application value.