Objective To explore the correlation between traditional Chinese medicine(TCM)syndromes of chronic gastritis and the indicators of five circuits and six qi,revealing the influence of different congenital qi endowments on TCM syndrome differentiation and providing evidence for individualized treatment.Methods Medical records meeting inclusion/exclusion criteria were collected from the Hospital Information System(HIS)of Rui Bao Street Community Health Service Center in Haizhu District,Guangzhou between January 20,2017 and January 20,2023.Data included age,birth date,and syndrome differentiation.Yearly circuit(Suiyun),celestial control-terrestrial effect(Sitian-Zaiqian)qi,three patterns of five circuits(Wuyun-Sanji),and syndrome patterns were statistically analyzed using Excel for database construction,with SPSS 23.0 for x2 tests and Logistic regression.Results(1)Among 1 882 chronic gastritis patients,spleen-stomach weakness(25.3％,477/1 882)was the most prevalent syndrome,followed by liver-stomach disharmony type,damp-heat in the spleen-stomach type,stomach-yin deficiency type,and stasis obstruction of stomach collateral type(x2=69.950,P=0.000).(2)Significant differences existed in Suiyun(Taijiao,Taigong,Taiyu,Taizhi,Shaogong,Taishang),Sitian-Zaiqian(Shaoyin-Yangming,Taiyin-Taiyang,Yangming-Shaoyin,Taiyang-Taiyin),and Wuyun-Sanji(excessive/insufficient earth/metal/water circuit)distributions among syndromes(P＜0.05 or P＜0.01).(3)For Suiyun-syndrome relationships:Birth in Taijiao/Shaogong years was the high-risk factor for developing chronic gastritis of liver-stomach disharmony type(P＜0.01);Taishang years were associated with stomach yin deficiency type(P＜0.05);Taijiao/Shaogong/Taiyu years were protective against damp-heat in the spleen-stomach type(P＜0.05 or P＜0.01).(4)For Sitian-Zaiqian-syndrome relationships:Jueyin-Shaoyang/Yangming-Shaoyin years linked to spleen-stomach weakness type(P＜0.05);Shaoyang-Jueyin years were correlated with damp-heat in the spleen-stomach type(P＜0.05).(5)For Wuyun-Sanji-syndrome relationships:Insufficient earth/water circuit years were associated with liver-stomach disharmony type(P＜0.05 or P＜0.01);excessive/balanced metal circuit years linked to stomach yin deficiency type(P＜0.05 or P＜0.01);insufficient metal circuit years were correlated with damp-heat in the spleen-stomach type(P＜0.05).Conclusion TCM syndromes of chronic gastritis are influenced by environment-body interactions,disordered visceral function and yin-yang imbalance.Clinical treatment should integrate the varied indicators of five circuits and six qi variations for personalized regimens to improve symptoms and quality of life.

AIM:To examine the effects of borneol on inflammation and myocardial remodeling after myocar-dial infarction(MI)in mice,and to investigate the underlying mechanisms.METHODS:Eight-week-old wild-type(WT)C57BL/6 mice and transient receptor potential cation channel subfamily M member 8(TRPM8)gene knockout(TRPM8-/-)mice were randomly divided into sham and MI groups,and were subsequently treated with normal saline(control group)or borneol(borneol group)via gavage.Survival curves were plotted for WT and TRPM8-/-mice with MI treated with or with-out borneol.After 28 d,cardiac function of the mice was assessed through echocardiography,and haemodynamic indexes were evaluated using a multi-channel physiological instrument.Infarct size,myocardial hypertrophy and interstitial fibro-sis were assessed via pathological staining.In addition,inflammatory response in the peri-infarct region was detected.RE-SULTS:The TRPM8 expression was up-regulated in the peri-infarct region of the mice with MI(P＜0.05),and borneol had no effect on TRPM8 expression(P＞0.05).Borneol increased the survival rate,reduced the infarct size,inhibited car-diac remodeling and improved cardiac function in WT mice with MI(P＜0.05 or P＜0.01).However,it did not affect the survival rate,infarct size,myocardial hypertrophy,myocardial fibrosis or cardiac function in TRPM8-/-mice(P＞0.05).Furthermore,borneol reduced inflammatory cell infiltration and the expression of inflammatory cytokines,tumor necrosis factor-α(TNF-α),interleukin-1β(IL-1β),IL-6 and monocyte chemotactic protein-1(MCP-1),in WT mice(P＜0.05 or P＜0.01)but not in TRPM8-/-mice(P＞0.05).CONCLUSION:Borneol attenuates inflammation,inhibits cardiac re-modeling and improves cardiac function in mice with MI via TRPM8.