Objective To explore terminal neuromagnetic activity and functional connectivity changes in childhood absence epilepsy(CAE)by multi-frequency magnetoencephalogram(MEG)analysis,and explore the mechanisms of termination and identify biological markers to better understand seizure termination and the recovery of consciousness.Methods This study recruited 20 drug-naive children with CAE and collected MEG data from 30 seizures and interictal periods using a MEG system.Minimum-norm estimation was used to model the distribution of the MEG data,the joint Welch method was used for Power Spectral Density(PSD)analysis,and corrected Amplitude Envelope Correlation was used to assess functional connectivity.Results During seizure termination,the low-frequency power decreased,with beta-band changes occurring first,while high-frequency power remained low and stable.Functional connectivity also shifted,showing transient increased synchrony in the delta band at seizure termination and continual reductions in alpha and beta connectivity.NBS analyses also showed the earliest whole-brain decrease in connectivity in the beta band and a transient enhancement of connectivity in the delta band 1 s before termination.Conclusion This study investigated neuromagnetic changes during seizure termination in CAE using MEG,highlighting the distinct roles of beta-band involvement and delta-band hypersynchronization in CAE termination.

Objective To explore terminal neuromagnetic activity and functional connectivity changes in childhood absence epilepsy(CAE)by multi-frequency magnetoencephalogram(MEG)analysis,and explore the mechanisms of termination and identify biological markers to better understand seizure termination and the recovery of consciousness.Methods This study recruited 20 drug-naive children with CAE and collected MEG data from 30 seizures and interictal periods using a MEG system.Minimum-norm estimation was used to model the distribution of the MEG data,the joint Welch method was used for Power Spectral Density(PSD)analysis,and corrected Amplitude Envelope Correlation was used to assess functional connectivity.Results During seizure termination,the low-frequency power decreased,with beta-band changes occurring first,while high-frequency power remained low and stable.Functional connectivity also shifted,showing transient increased synchrony in the delta band at seizure termination and continual reductions in alpha and beta connectivity.NBS analyses also showed the earliest whole-brain decrease in connectivity in the beta band and a transient enhancement of connectivity in the delta band 1 s before termination.Conclusion This study investigated neuromagnetic changes during seizure termination in CAE using MEG,highlighting the distinct roles of beta-band involvement and delta-band hypersynchronization in CAE termination.

OBJECTIVETo observe the clinical efficacy differences between different needling methods for dry eye syndrome.

METHODSSixty patients of dry eye syndrome were randomly divided into an observation group and a control group, 30 cases (60 eyes) in each group. Shangjingming (Extra), Xiajingming (Extra), Tongziliao (GB 1), Cuanzhu (BL 2), Fengchi (GB 20), Hegu (LI 4), Sanyinjiao (SP 6), Taixi (KI 3) and Taichong (LR 3) were selected in the two groups. The control group was treated with conventional acupuncture, while the observation group was treated with guiding-acupuncture. Electroacupuncture (EA) was used at bilateral Tongziliao (GB1) and Cuanzhu (BL 2), 30 min per treatment. The treatment was given three times per week. Totally 1-month treatment (12 treatments) was given. The eye symptom score, breakup time of tear film (BUT), Schirmer Ⅰ test (SⅠT) and visual analogue scale (VAS) score were compared before and after treatment in the two groups. The clinical efficacy was compared between the two groups.

RESULTSCompared before treatment, the eye symptom score, BUT, SⅠT and VAS score were improved after treatment in the two groups (all<0.001); the improvements of eye symptom score and SⅠT in the observation group were superior to those in the control group (both<0.05). The differences of BUT and VSA score between the two groups were not significant (both>0.05). The total effective rate was 86.7% (52/60) in the observation group, which was superior to 73.3% (44/60) in the control group (<0.05). .

CONCLUSIONThe conventional EA and guiding-acupuncture combined with EA are both effective for dry eye syndrome, and the efficacy of guiding-acupuncture combined with EA is superior to that of conventional EA.