The idea that Gypsum Fibrosum can release flesh has a long history， but its clinical popularization， application， and in-depth discussion are insufficient due to the problems of mineral drug dissolution and limited research means. Through the analysis of releasing flesh method （RFM）， this paper concluded that the RFM-targeted pathogenesis was deficiency of body fluid and disturbance in the exterior， and the core connotation of RFM of Gypsum Fibrosum was clearing heat to restore fluid and expelling pathogenic factors in the exterior. Based on the ancient and modern application of RFM and modern research on coordination chemistry， this paper enriched the connotation of RFM of Gypsum Fibrosum from compatibility with traditional Chinese medicine （TCM） classical prescriptions recorded in the Treatise on Cold Damage （《伤寒论》） and Synopsis of the Golden Chamber （《金匮要略》） as examples. Specifically， in addition to muscle discomfort symptoms after external contraction， RFM of Gypsum Fibrosum could also affect the function of internal organs， thereby treating internal injuries and miscellaneous diseases. Moreover， a new idea， RFM of Gypsum Fibrosum by compatibility， was proposed， that the fresh-releasing effect of Gypsum Fibrosum could be markedly exerted through compatibility with Ephedrae Herba， Puerariae Lobatae Radix， Stephaniae Tetrandrae Radix， Anemarrhenae Rhizoma， Ginseng Radix et Rhizoma， Paeoniae Radix Alba， Bambusae Caulis in Taenias， Rehmanniae Radix， Ophiopogonis Radix， and Polygonati Odorati Rhizoma by adjusting the expelling and heat-clearing intensity. A clinical case was presented to provide a reference for the clinical application of Gypsum Fibrosum and a direction for the study of drug mechanism of compatibility.