Objective To explore the pathogenesis and prognostic factors of liposarcoma in the head and neck region, and simultaneously analyze the efficacy of different treatment regimens. Methods A retrospective analysis was performed on all patients with primary untreated head and neck liposarcoma who were diagnosed and underwent surgical treatment at our hospital from January 2008 to January 2024. All patients were monitored during follow-up, and their prognoses were analyzed using SPSS software. Results A total of 30 patients were included in the study. Liposarcoma accounted for up to 60% of the cases in the orbit, while the remaining liposarcomas were primarily located in various interspaces of the neck. Dedifferentiated liposarcoma was the most common type, comprising 33%, while myxoid pleomorphic liposarcoma was the rarest at 4%. The tumor pathological type (P<0.001) and Ki67 (P=0.014) significantly affected the tumor control rate. However, an analysis of disease-specific survival rates revealed no significant differences across various factors (all P>0.05). Conclusion The prognosis of head and neck liposarcoma is better compared to that of liposarcomas in other parts of the body. However, myxoid pleomorphic liposarcoma, pleomorphic fat sarcoma, and high Ki67 levels are indicators of poor prognosis. Additionally, postoperative adjuvant radiotherapy does not significantly enhance disease-specific survival rates.

Abstract Upper cross syndrome (UCS) is an abnormal body posture phenomenon. The detection rate of UCS in adolescents is high in China, which has become a serious public health problem threatening the health of adolescents. Exercise therapy has a positive effect on the prevention and treatment of UCS.The article reviews the pathological mechanisms of muscle imbalance, muscle interaction inhibition, and neural control related to the occurrence and development of UCS both domestically and internationally in recent years.And it elucidates the effects and corresponding mechanisms of exercise interventions such as gentle exercise, stretching exercise and physical function training on UCS, so as to provide help for the correction of UCS.

The core idea of occupational health risk assessment models is to systematically evaluate occupational health risks according to target hazard characteristics and relevant exposure levels of workers. Occupational exposure assessment is based on concentration, frequency, exposure time, and other indicators that indicate actual exposure of workers to occupational hazards, which is a critical component of health risk assessment. However, the accuracy and comparability of assessment results are affected by differences in parameter assignment for exposure assessment across different studies, as well as insufficient emphasis on multiple occupational hazard exposure. This review aimed to explore the assignment and standardization of exposure assessment parameters for occupational health risk assessment modeling, and systematically sorted out the meaning, assignment methods, and sources of exposure assessment related parameters in commonly used occupational health risk assessment models, with the goal of providing researchers with standardized assessment tools to enhance the scientific rigor and practicality of occupational health risk assessments. Considering the individual differences and temporal fluctuations in occupational exposure, it is recommended that researchers should adopt appropriate sampling strategies, reasonably select sample subjects and time based on the division of similar exposure group (SEG), and conduct statistical inference on the obtained data to derive representative exposure parameters. For combined exposure to chemicals with similar toxic effects, the health risk assessment methods are relatively mature. However, the assessment of combined exposure to hazards with different properties and health effects still lacks scientific authority and needs further research and discussion.

Objective: To explore the potential classification of 24 hour activity time allocation among college students in Yinchuan and its association with active health levels, so as to provide references for optimizing activity time allocation to enhance active health levels. Methods: From November 18 to December 6, 2024, a stratified cluster random sampling method was used to select 2 422 first and second year college students from full time undergraduate institutions in Yinchuan. The Chinese College Students 24 hour Movement Behaviors Questionnaire (24 h MBQ) and Active Health Behavior Scale were used to assess 24 hour activity time allocation and evaluate active health levels. Latent profile analysis (LPA) was employed to categorize activity types, and a binary Logistic regression analysis was conducted to analyze the relationship between active health levels and activity types. Results: A total of 1 087 students (44.9%) were found of meeting active health standards, and significant statistical differences were found in active health levels across different genders, grades, academic qualities, sources of origin and academic categories ( χ 2= 22.03 , 7.65, 25.50, 10.12, 43.44, all P <0.01). Moreover, significant statistical differences could also be found among college students 24 hour activity time across different genders, ages, grades, sources of origin, academic qualities, and academic categories ( t/Z/H/F=-5.70-111.39, P <0.05).The 24 hour activity time allocation was classified into four types:academic high ( 6.9 %), low activity rest (8.8%), light activity (67.8%), and high activity dynamic (16.4%). Significant statistical differences were observed in activity time allocation categories across different ages, academic qualities and academic categories ( χ 2=15.52-108.46, all P <0.05). Using the high activity dynamic type as a reference, the light activity type ( OR=0.39, 95%CI =0.31-0.50), low activity rest type ( OR=0.10, 95%CI =0.06-0.15), and academic high type ( OR=0.03, 95%CI =0.02-0.07) had lower active health levels among college students (all P <0.01). Conclusion There is a significant difference in 24 hour activity time allocation among college students in Yinchuan, and different activity types are associated with active health levels.

Objective　By comparing the changes in public health emergency response capacity and epidemic response effect in Yangzhou before and after the outbreak of COVID-19, we can provide a reference for epidemic prevention and control work in the post-COVID-19 era. Methods　The three periods of 2018-2019, 2020-2022, and 2023 were selected to correspond to the pre-COVID-19 period, the middle period, and the post-COVID-19 period, respectively, and the epidemic period of COVID-19 was divided into two sub-dimensions: the early epidemic period of 2020 and the high-intensity epidemic period of 2021-2022. Through questionnaire surveys and descriptive epidemiology, a comprehensive comparison was conducted on all aspects of emergency response capacity and the effectiveness of epidemic management. Results　Since the outbreak of COVID-19, the Yangzhou emergency response system has set up a joint control and prevention network of cities, counties, and districts, as well as special emergency departments in all regions; optimized the personnel allocation and professional disposal teams; improved the number, mode, and coverage of emergency plans, emergency drills, and training; optimized emergency material reserve and dispatch; and standardized institutional construction. The overall incidence of influenza outbreaks decreased from 2.71% to 1.03% and 1.50%; During the different epidemic periods of COVID-19, the average duration of influenza outbreaks decreased continuously, which was 16.70, 11.34, and 9.88 days, respectively. The proportion of influenza outbreaks that met the criteria for a public health emergency controlled within an average incubation period increased from 18.75% in the pre-COVID-19 period to 75.00% in the post-COVID-19 period. Conclusion　The public health emergency response capacity of Yangzhou city has been improved after the COVID-19 epidemic, but there are still shortcomings in the emergency management mechanism, the function of emergency departments, the multi-trigger monitoring warning system, the quantity and quality of professionals, and the multi-department coordination mechanism. In particular, the capacity of county-level emergency response teams needs to be continuously strengthened, which can be achieved by gradually improving emergency management systems and monitoring warning systems, further strengthening talent training, continuously promoting the integration of medical and prevention, and focusing on practical effects.

[摘 要] 目的：探究三七总皂苷（PNS）通过JAK2/STAT3通路调控巨噬细胞极化对小鼠黑色素瘤B16-F10细胞的活力的影响。方法：常规培养B16-F10细胞和巨噬细胞RAW264.7，MTT法检测不同浓度PNS对RAW264.7或B16-F10细胞存活率的影响。实验分为空白组（仅B16-F10细胞）、对照组（B16-F10细胞与RAW264.7细胞共培养）、不同浓度（50、100、200 μg/mL）PNS组（B16-F10细胞与RAW 264.7细胞共培养）及200 μg/mL PNS + colivelin[（B16-F10细胞与RAW264.7细胞共培养，0.5 μmol/L colivelin JAK2/STAT3通路激活剂）]组，MTT法、流式细胞术检测各组共培养细胞的存活率和凋亡率，显微镜观察巨噬细胞形态变化；ELISA实验检测上清液中相关细胞因子TNF-α、IL-6、IL-1β的水平，qPCR法检测巨噬细胞极化相关基因诱导型一氧化氮合酶（iNOS）、IL-12、CD206、精氨酸酶-1（Arg-1）mRNA表达，WB法检测细胞中JAK2、STAT3蛋白磷酸化水平。结果：不同浓度PNS对单独培养的RAW264.7、B16-F10细胞的存活率均无明显影响（均P > 0.05）。与对照组相比，PNS呈浓度依赖性地促进共培养细胞凋亡、IL-6、TNF-α、IL-1β蛋白和IL-12、iNOS mRNA表达水平均显著增加（均P < 0.05），降低共培养细胞的存活率、JAK2与STAT3蛋白磷酸化水平（均P < 0.05），PNS对共培养细胞的作用部分被colivenlin抑制。结论：PNS通过抑制JAK2/STAT3通路促进M1巨噬细胞极化进而抑制小鼠黑色素瘤B16-F10细胞的活力。

Various types of industrial parks in Shanghai play an important role in promoting industrial upgrading and technological progress， yet they are also fraught with occupational health hazards. To effectively promote workplace health and enable various industrial parks to play a positive role， the Shanghai Municipal Government has proposed accelerating the construction of healthy industrial parks. To meet the requirements for the scientific and standardized construction of healthy parks， the Shanghai Municipal Center for Disease Control and Prevention has compiled the Guidelines for Healthy Industrial Park Construction（Guidelines）. Adhering to the overall principles of scientific， feasibility， advancement， and standardization， the Guidelines address three construction levels： industrial parks， employers， and employees. They set clear requirements for organizational management， healthy environments， health services， health activities， and occupational health in the workplaces， respectively. The Shanghai healthy industrial park evaluation form was provided as an informative appendix for the Guidelines. The Guidelines offer a scientific basis for standardizing and guiding the construction of healthy industrial parks， providing new solutions and technical support for urban occupational health management.

The BTB (broad-complex, tramtrack, and bric-à-brac) domain is a highly conserved protein interaction motif in eukaryotes. They are widely involved in transcriptional regulation, protein degradation and other processes. Recently, an increasing number of studies have shown that these genes play important roles in plant growth and development, biotic and abiotic stress processes. Here, we summarize the advances of these proteins ubiquitination-mediated development and abiotic stress responses in plants based on the protein structure, which may facilitate the study of this type of gene in plants.
Eukaryota ; Plant Development/genetics* ; Proteolysis ; Ubiquitination

With the rapid society development and broad recognition of "Healthy China", the demands for good life and health are increasing. Accordingly, the concept of "food and medicine homologous" have been attractive. The concept of "food and medicine homologous" has a long history in China, and is an essence of various ideas in traditional Chinese medicine, such as diet therapy, medicated diet, regimen and preventive treatment of disease, representing an important field in health science. Many studies have found that the active ingredients of "food and medicine homologous" substances are multiple types, multiple mechanisms and multiple targets, exerting their biological effects after oral administration and chemical or metabolic transformation. In this review, the chemical basis and biological principles of various "food and medicine homologous" substances were summarized as compounds, biological macromolecules and intestinal flora. By focusing on the intestinal flora, we discussed the detailed biological principles of several classic "food and medicine homologous" substances. The scientific significance of "food and medicine homologous" concept were also discussed. This review explores the concept of "food and medicine homologous" from the perspective of modern medicine, in order to provide insights for future drug development and human health.

Objective: To analyze the HIV detection results through different detection routes in Jiading District, Shanghai Municipality from 2009 to 2023, so as to provide the reference for improving HIV detection measures. Methods: Data pertaining to HIV detection in Jiading District from 2009 to 2023 was collected through the HIV/AIDS Comprehensive Control System of Chinese Disease Prevention and Control Information System. The number of HIV detection and HIV positive rates through detection routes including voluntary counseling and testing (VCT) clinics, sexually transmitted disease (STD) clinics, pre-operation and blood transfusion (products), premarital and antenatal periods, other clinical outpatients and other populations were described. Results: A total of 1 729 347 HIV tests were conducted in Jiading District from 2009 to 2023, with an average annual growth rate of 7.55%. A total of 1 125 HIV positive cases were confirmed, with an HIV positive rate of 6.51/104. The number of HIV detection conducted in VCT clinics, STD clinics, pre-operation and blood transfusion (products), premarital and antenatal periods, other clinical outpatients and other populations were 11 516, 112 880, 692 609, 635 770, 196 315 and 80 257, respectively. The main detection routes were pre-operation and blood transfusion (products) as well as premarital and antenatal periods, accounting for 40.05% and 36.76%, respectively. The HIV positive rates in VCT clinics, STD clinics, pre-operation and blood transfusion (products), premarital and antenatal periods, other clinical outpatients and other populations were 336.05/104, 21.79/104, 2.93/104, 0.35/104, 10.95/104 and 6.48/104, respectively. The HIV positive rate in VCT clinics was higher than that in other detection routes (all P<0.001). Conclusions From 2009 to 2023, the number of HIV tests increased in Jiading District, mainly through pre-operation and blood transfusion (products) as well as premarital and antenatal periods. The HIV positive rate was the highest in VCT clinics.