Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Taking the scope of outpatient special disease,the level of protection and the fixed-point management as the entry point.Under the"N+X"policy background,it reviewed the policies related to outpatient special diseases in 13 co-ordinated districts of Jiangsu Province to explore the similarities and differences and the existing problems,and provide relevant suggestions.Jiangsu Province has issued a guiding document to establish a unified outpatient special disease system,the differences in the scope of outpatient special disease and the medical insurance benefit level in the 13 cities should not be ignored.These differences may affect the fairness of patients and hinder the establishment of a unified outpatient special disease system in the province.In addition,there are still some problems in the selection of diseases,hierarchical medical,and disease identification.It is recommended to establish a dynamic selection mechanism for outpatient special diseases,to fully utilize the role of primary healthcare institutions in providing outpatient services for special diseases,and to develop objective and unified criteria for identifying outpatient special diseases.

Objective To explore the effect of Yizheng Recipe on pyroptosis of alveolar epithelium in rats with recurrent respiratory tract infection(RRTI)based on HMGB1/TLR4/NF-κB signal pathway.Methods SD rats were firstly grouped into normal group and model group.In the model group,the RRTI rat model of spleen-Qi deficiency and lung- Qi deficiency was induced by fatigue combined with diet disorder and shavings and tobacco leaf smoking.Then,the rats in the model group were grouped into:RRTI model group(gavaged with normal saline 0.5 mL·100 g-1·d-1)and Yupingfeng Powder control treatment group(gavaged with Yupingfeng Powder suspension 0.5 mL·100 g-1·d-1),Yizheng Recipe high,medium and low-dose treatment groups(gavaged with Yizheng Recipe 0.75,0.5,0.25 mL·100 g-1·d-1),the normal group(gavaged with normal saline 0.5 mL·100 g-1·d-1).The general activities of the rats were observed and the pulmonary function of the rats was detected by the AniRes2005 animal pulmonary function analysis system;the expression of inflammatory factors in rat serum was detected by ELISA;HE,PAS and TUNEL staining were applied to detect the pathological changes of lung tissue;Western blot was applied to detect cell pyroptosis and the expression of HMGB1/TLR4/NF-κB signaling pathway-related proteins.Results Compared with the normal group,the lung function of the RRTI model group was weakened;the inflammatory response increased,and the lung tissue damage,edema and apoptosis were obviously increased;meantime,the pyroptosis was aggravated,and the HMGB1/TLR4/NF-κB pathway was activated(P<0.05).Compared with the RRTI model group,the Yupingfeng Powder control treatment group and the Yizheng Recipe high-dose,medium-dose and low-dose treatment groups all had different degrees of remission in lung function;inflammatory response reduced,the lung tissue damage,edema and apoptosis reduced;meantime,the pyroptosis and HMGB1/TLR4/NF-κB pathway were inhibited(P<0.05).Yizheng Recipe high-dose treatment group and Yupingfeng Powder control treatment group had similar curative effect on RRTI model rats(P>0.05);and Yizheng Recipe was dose-dependent in treating RRTI model rats(P<0.05).Conclusion Yizheng Recipe may inhibit the pyroptosis of alveolar epithelial cells in RRTI model rats by reducing the inflammatory response,and then protecting the lung tissue from damage,this process may be related to the HMGB1/TLR4/NF-κB pathway.

Objective:To evaluate the diagnostic value of multiparametric cardiac magnetic resonance(CMR)or detecting the occurrence of acute rejection(AR)after heart transplantation(HT).Methods:From 2019 to 2021, 44 HT recipients are prospectively recruited from Guangdong Provincial People's Hospital.Another 51 healthy volunteers are recruited from a local community as healthy controls.CMR studies are performed for obtaining baseline parameters.According to the clinicopathological diagnostic criteria of AR by the consensus of International Society for Heart and Lung Transplantation, 81 CMR studies of 44 HT recipients are further divided into two groups of AR (18 cases)and non-AR(71 cases). CMR parameters includ global ventricular structure/function, T2, T1, extracellular volume(ECV)and late gadolinium enhancement(LGE). A combined model is established by binary Logistic regression and receiver operator characteristic curve(ROC)constructed.Results:The age range is(41.8±16.8)years in 44 HT recipients and(41.8±9.7)years in 51 healthy controls.T1 mapping indicated that myocardial global ECV of left ventricle is significantly higher in AR patients than non-AR controls(32.4%±6.0% vs 28.5%±2.4%; P<0.001 9). Global native T1 is higher in AR group than that in non-AR group(49.8±3.1 vs 47.5±2.8 ms, P=0.009)and the difference is statistically significant.The cutoff value of global ECV is 30.62% with a sensitivity of 61% and a specificity of 86% for detecting AR.And T2 mapping reveale that T2 value of global left ventricle is significantly higher in AR group than that in non-AR group(49.8±3.1 vs 47.5±2.8 ms, P=0.009). LGE extent is significantly higher in AR group than those in non-AR group( P=0.004). Through including global native T1 and ECV into a logistic regression model, multiparametric CMR can yield an area under curve(AUC)of 0.794.It hints at the potential of CMR for detecting AR. Conclusions:Multiparametric cardiac magnetic resonance offers an excellent predictive capacity for a noninvasive detection of AR.