The randomized controlled trials (RCTs) regarding acupuncture direction published from January 1st, 2013, to November 7th, 2023 were searched in China National Knowledge Infrastructure (CNKI), Wanfang Data Knowledge Service Platform, and VIP Chinese Journal Database. As a result, 21 RCTs were included. The problems identified included conceptual misunderstandings regarding acupuncture direction, incomplete selection strategies, confounding research factors, and inaccuracies in reporting. Based on the findings, four strategic approaches for enhancing therapeutic efficacy through acupuncture direction were summarized: aligning needle direction with the meridian pathway, directing the needle toward the lesion site, orienting the needle toward adjacent acupoints, and targeting special anatomical structures. Two additional strategies were proposed for optimizing the procedure: simplifying acupuncture operations and directing the needle toward safe anatomical sites. Recommendations were made to improve the rationality of research factor settings and the completeness of acupuncture operation reporting. Furthermore, three methods for reporting acupuncture direction were discussed: reporting the tip-pointed position, reporting the insertion angle and orientation, and reporting azimuth and polar angles, aiming to promote greater standardization and completeness in acupuncture practice and reporting.
Acupuncture Therapy/standards* ; Humans ; Acupuncture Points ; Randomized Controlled Trials as Topic ; Meridians

Objective: To analyze the characteristics of alcohol poisoning cases among minors receiving pre hospital 120 emergency services in Zhengzhou, providing evidence for regional management strategies of alcohol poisoning among minors. Methods: A retrospective study was conducted on 1 630 alcohol poisoning cases (aged 0-18 years) from Zhengzhou s 120 emergency system during 2017-2019 and 2023. Data on gender, age, occurrence timeframes were analyzed using t-test and χ 2 test for intergroup comparisons. Results: Annual cases were 291 (2017), 353 (2018), 483 (2019), and 503 (2023). Compared with 2017, male alcohol poisoning cases increased by 66.94% while female cases surged 104.35% by 2023. The peak incidence of alcohol poisoning among minors occurred among 16-18 year olds (85.40%), followed by 13-15 year olds (13.74%). Most cases clustered between 21:01-03:00 (60.43%), with male cases peaking at 22:01-23:00 (12.73%) and female cases peaking at 02:01-03:00 ( 11.25 %). Between 00:01-03:00, male cases progressively decreased while female cases increased. Severity distribution showed 355 mild cases (21.78%), 1 035 moderate cases (63.50%), and 240 severe cases (14.72%). Conclusions Zhengzhou region has experienced sustained growth in underage alcohol poisoning cases, predominantly occurring from evening to early morning with moderate severity, female cases demonstrate faster growth rates. Multifaceted regulatory measures should be implemented to strengthen supervision of underage drinking behaviors.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Objective:To explore the policy synergy of 71 Diagnosis-Intervention Packet(DIP)pilot cities from the perspective of policy synergy at both the national and provincial levels.Methods:Policy evaluation dimensions were constructed by text mining method,and the surface plots of policy consistency were drawn by the Policy Modeling Consistency Index(PMC),and the degree of policy synergy between each city and national policies and with cities in the province were calculated by correlation analysis.Results:Different levels of policy in pilot cities and the policy differences among pilot cities mainly focus on policy disclosure,core elements,and infrastructure,at the central level,most cities maintain a high degree of consistency with the state in terms of policy nature,management measures,infrastructure,and policy evaluation,and the policy timeliness,policy perspective,and core elements still need to be improved;at the provincial level,cities within the 20 provinces show characteristics in low level of complete synergy,high level of close synergy and differentiated partial synergy.Conclusion:The 71 DIP pilot cities have established a preliminary policy system,but there are still more cities with missing policies and a lack of coordination.In the future,efforts should be made to advance the policy development process,promote the improvement of the policy system,and promote coordination among pilot cities in policy implementation.

Background::In vitro fertilization (IVF) has emerged as a transformative solution for infertility. However, achieving favorable live-birth outcomes remains challenging. Current clinical IVF practices in IVF involve the collection of heterogeneous embryo data through diverse methods, including static images and temporal videos. However, traditional embryo selection methods, primarily reliant on visual inspection of morphology, exhibit variability and are contingent on the experience of practitioners. Therefore, an automated system that can evaluate heterogeneous embryo data to predict the final outcomes of live births is highly desirable. Methods::We employed artificial intelligence (AI) for embryo morphological grading, blastocyst embryo selection, aneuploidy prediction, and final live-birth outcome prediction. We developed and validated the AI models using multitask learning for embryo morphological assessment, including pronucleus type on day 1 and the number of blastomeres, asymmetry, and fragmentation of blastomeres on day 3, using 19,201 embryo photographs from 8271 patients. A neural network was trained on embryo and clinical metadata to identify good-quality embryos for implantation on day 3 or day 5, and predict live-birth outcomes. Additionally, a 3D convolutional neural network was trained on 418 time-lapse videos of preimplantation genetic testing (PGT)-based ploidy outcomes for the prediction of aneuploidy and consequent live-birth outcomes.Results::These two approaches enabled us to automatically assess the implantation potential. By combining embryo and maternal metrics in an ensemble AI model, we evaluated live-birth outcomes in a prospective cohort that achieved higher accuracy than experienced embryologists (46.1% vs. 30.7% on day 3, 55.0% vs. 40.7% on day 5). Our results demonstrate the potential for AI-based selection of embryos based on characteristics beyond the observational abilities of human clinicians (area under the curve: 0.769, 95% confidence interval: 0.709–0.820). These findings could potentially provide a noninvasive, high-throughput, and low-cost screening tool to facilitate embryo selection and achieve better outcomes. Conclusions::Our study underscores the AI model’s ability to provide interpretable evidence for clinicians in assisted reproduction, highlighting its potential as a noninvasive, efficient, and cost-effective tool for improved embryo selection and enhanced IVF outcomes. The convergence of cutting-edge technology and reproductive medicine has opened new avenues for addressing infertility challenges and optimizing IVF success rates.

Objective To optimize the operational steps and processes in mouse cervical heterotopic heart transplantation by modifying the conventional cuff technique for vascular anastomosis and consequently establish a more stable cervical heterotopic heart transplantation model in mice.Methods C57BL/6 male mice (6～8 weeks old,weighing 20～24 g)were categorized into control (conventional cuff technique)and experimental groups (our"Anchoring Node"technique).Time for each surgical step,frequencies of vascular everting and vascular trimming,and the reasons for failure were recorded and compared between the 2 groups. Postoperative survival of heart allograft was determined by daily observation and touching,and the mice with the survival time>48 h were considered as successful model establishment.On the 7th and 14th days after surgery,HE staining was used to observe the pathologic changes in the vascular tissues at anastomosis.The expression of troponin T (cTnT)in the heart on the 7th day was detected with immunofluorescence assay. Results ① In the 25 hearts from each group,2 hearts from the experimental group and 8 from the control group failed,and the survival rate of heart allografts was 92％and 68％,respectively.In the experimental group,arterial and venous everting occurred at an average of 1 .16 times,with an average frequency of trimming of 0.04 times,while in the control group,arterial and venous everting was 2.00 and 2.28 times,respectively,with an average frequency of trimming of 0.21 and 0.46 times,respectively.② Significant differences were observed in the overall duration for cervical heterotopic heart transplantation (77.22±3.82 vs 87.49±8.01 min),vascular separation plus cannulation (30.06±2.68 vs 36.50±6.67 min),and cervical anastomosis (7.31±1 .08 vs 12.34±2.58 min)between the experimental and control groups (all P<0.05).③HE staining displayed that vascular patency was observed in the experimental group on the 7th and 14th days after surgery.④cTnT staining indicated no massive myocardial necrosis was seen in both groups. Conclusion Based on conventional cuff technique for mouse cervical heterotopic heart transplantation,our modified"Anchoring Node"technique ensures the stability and efficiency of one-man microscopic operation with controllable quality,with the advantages of longer postoperative survival of heart allograft,high patency rate of anastomotic vessels,good cardiac function,and fewer postoperative complications.