Objective: To evaluate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating tumor deposits (TDs) from metastatic lymph nodes (MLNs) in rectal cancer. Materials and Methods: A retrospective analysis was conducted on 70 patients with rectal cancer, including 168 lesions (70 TDs and 98 MLNs confirmed by histopathology), who underwent pretreatment MRI and subsequent surgery between March 2019 and December 2022. The morphological characteristics of TDs and MLNs, along with quantitative parameters derived from DCE-MRI (K trans , kep, and v e) and DWI (ADCmin, ADCmax, and ADCmean), were analyzed and compared between the two groups.Multivariable binary logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of significant individual quantitative parameters and combined parameters in distinguishing TDs from MLNs. Results: All morphological features, including size, shape, border, and signal intensity, as well as all DCE-MRI parameters showed significant differences between TDs and MLNs (all P < 0.05). However, ADC values did not demonstrate significant differences (all P > 0.05). Among the single quantitative parameters, v e had the highest diagnostic accuracy, with an area under the ROC curve (AUC) of 0.772 for distinguishing TDs from MLNs. A multivariable logistic regression model incorporating short axis, border, v e, and ADC mean improved diagnostic performance, achieving an AUC of 0.833 (P = 0.027). Conclusion The combination of morphological features, DCE-MRI parameters, and ADC values can effectively aid in the preoperative differentiation of TDs from MLNs in rectal cancer.

Objective: To evaluate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating tumor deposits (TDs) from metastatic lymph nodes (MLNs) in rectal cancer. Materials and Methods: A retrospective analysis was conducted on 70 patients with rectal cancer, including 168 lesions (70 TDs and 98 MLNs confirmed by histopathology), who underwent pretreatment MRI and subsequent surgery between March 2019 and December 2022. The morphological characteristics of TDs and MLNs, along with quantitative parameters derived from DCE-MRI (K trans , kep, and v e) and DWI (ADCmin, ADCmax, and ADCmean), were analyzed and compared between the two groups.Multivariable binary logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of significant individual quantitative parameters and combined parameters in distinguishing TDs from MLNs. Results: All morphological features, including size, shape, border, and signal intensity, as well as all DCE-MRI parameters showed significant differences between TDs and MLNs (all P < 0.05). However, ADC values did not demonstrate significant differences (all P > 0.05). Among the single quantitative parameters, v e had the highest diagnostic accuracy, with an area under the ROC curve (AUC) of 0.772 for distinguishing TDs from MLNs. A multivariable logistic regression model incorporating short axis, border, v e, and ADC mean improved diagnostic performance, achieving an AUC of 0.833 (P = 0.027). Conclusion The combination of morphological features, DCE-MRI parameters, and ADC values can effectively aid in the preoperative differentiation of TDs from MLNs in rectal cancer.

Objective To explore the mechanism of action of total flavonoids of Rhizoma drynariae(TFRD)in improving lipid metabolism disorders in rabbits with avascular necrosis of femoral head(SANFH)based on the peroxisome proliferator-activated receptor γ(PPARγ)/adenosine monophosphate-activated protein kinase(AMPK)pathway.Methods Sixty New Zealand rabbits were randomly divided into the control group(n=10)and the model group(n=50).The rabbit SANFH model was established by injecting Escherichia coli endotoxin and methylprednisolone.The control group was injected with the same amount of physiological saline.The SANFH model was randomly classified into five subgroups:the SANFH group,the TFRD-low group(30 mg/kg),the TFRD-medium group(60 mg/kg),the TFRD-high group(100 mg/kg)and the TFRD-high+inhibitor(TFRD 100 mg/kg+AMPK inhibiter 30 mg/kg)group,with 10 rabbits in each subgroup.After the intervention,venous blood sample was collected from the rabbit ear margin,and serum lipid levels[high-density lipoprotein cholesterol(HDL-C)and total cholesterol,triglycerides(TG)]were detected.Micro-CT was used to detect bone volume/total volume(BV/TV)(%)and trabecular quantity(Tb.N).Hematoxylin-eosin(HE)staining was used to observe histopathological changes of femur and calculate empty bone lacuna rate.TUNEL was used to detect apoptosis of femoral tissue.Real-time fluorescence quantitative reverse transcription polymerase chain reaction(qRT-PCR)was employed to analyze the expression of B-cell lymphoma/leukemia-2(Bcl-2)and Bcl-2-related X protein(Bax)mRNA.Western blot assay was used to detect the expression of tissue-related proteins(PPARγ and p-AMPK/AMPK).Results Compared with the control group,HDL-C,BV/TV,Tb.N,Bcl-2 mRNAs,PPARγ and p-AMPK/AMPK were decreased in the SANFH group,and cholesterol,TG,apoptosis rate,empty bone lacuna rate and Bax mRNA were increased(P＜0.05).Compared with the SANFH group,HDL-C,BV/TV,Tb.N,Bcl-2 mRNAs,PPARγ and p-AMPK/AMPK were increased in sequence in the TFRD-low group,the TFRD-medium group and the TFRD-high group,and cholesterol,TG,apoptosis rate,empty bone lacuna rate and Bax mRNA were decreased in turn(P＜0.05).Compared with the TFRD-high group,changes in the above indicators were reversed in the TFRD-high+inhibitor group(P＜0.05).Conclusion TFRD improves lipid metabolism disorder in SANFH rabbits by activating PPARγ/AMPK pathway.

With the rapid development of generative artificial intelligence(GAI)technologies,their widespread application in academic research and writing is continuously expanding the boundaries of sci-entific inquiry.However,this trend has also raised a series of ethical and regulatory challenges,inclu-ding issues related to authorship,content authenticity,citation accuracy,and accountability.In light of the growing involvement of AI in generating academic content,establishing an open,controllable,and trustworthy ethical governance framework has become a key task for safeguarding research integrity and maintaining trust within the academic community.This expert consensus outlines ethical requirements across key stages of AI-assisted academic writing-including topic selection,data management,citation practices,and authorship attribution.It aims to clarify the boundaries and ethical obligations surrounding AI use in academic writing,ensuring that technological tools enhance efficiency without compromising in-tegrity.The goal is to provide guidance and institutional support for building a responsible and sustainable research ecosystem.

Objective To explore the mechanism of action of total flavonoids of Rhizoma drynariae(TFRD)in improving lipid metabolism disorders in rabbits with avascular necrosis of femoral head(SANFH)based on the peroxisome proliferator-activated receptor γ(PPARγ)/adenosine monophosphate-activated protein kinase(AMPK)pathway.Methods Sixty New Zealand rabbits were randomly divided into the control group(n=10)and the model group(n=50).The rabbit SANFH model was established by injecting Escherichia coli endotoxin and methylprednisolone.The control group was injected with the same amount of physiological saline.The SANFH model was randomly classified into five subgroups:the SANFH group,the TFRD-low group(30 mg/kg),the TFRD-medium group(60 mg/kg),the TFRD-high group(100 mg/kg)and the TFRD-high+inhibitor(TFRD 100 mg/kg+AMPK inhibiter 30 mg/kg)group,with 10 rabbits in each subgroup.After the intervention,venous blood sample was collected from the rabbit ear margin,and serum lipid levels[high-density lipoprotein cholesterol(HDL-C)and total cholesterol,triglycerides(TG)]were detected.Micro-CT was used to detect bone volume/total volume(BV/TV)(%)and trabecular quantity(Tb.N).Hematoxylin-eosin(HE)staining was used to observe histopathological changes of femur and calculate empty bone lacuna rate.TUNEL was used to detect apoptosis of femoral tissue.Real-time fluorescence quantitative reverse transcription polymerase chain reaction(qRT-PCR)was employed to analyze the expression of B-cell lymphoma/leukemia-2(Bcl-2)and Bcl-2-related X protein(Bax)mRNA.Western blot assay was used to detect the expression of tissue-related proteins(PPARγ and p-AMPK/AMPK).Results Compared with the control group,HDL-C,BV/TV,Tb.N,Bcl-2 mRNAs,PPARγ and p-AMPK/AMPK were decreased in the SANFH group,and cholesterol,TG,apoptosis rate,empty bone lacuna rate and Bax mRNA were increased(P＜0.05).Compared with the SANFH group,HDL-C,BV/TV,Tb.N,Bcl-2 mRNAs,PPARγ and p-AMPK/AMPK were increased in sequence in the TFRD-low group,the TFRD-medium group and the TFRD-high group,and cholesterol,TG,apoptosis rate,empty bone lacuna rate and Bax mRNA were decreased in turn(P＜0.05).Compared with the TFRD-high group,changes in the above indicators were reversed in the TFRD-high+inhibitor group(P＜0.05).Conclusion TFRD improves lipid metabolism disorder in SANFH rabbits by activating PPARγ/AMPK pathway.

With the rapid development of generative artificial intelligence(GAI)technologies,their widespread application in academic research and writing is continuously expanding the boundaries of sci-entific inquiry.However,this trend has also raised a series of ethical and regulatory challenges,inclu-ding issues related to authorship,content authenticity,citation accuracy,and accountability.In light of the growing involvement of AI in generating academic content,establishing an open,controllable,and trustworthy ethical governance framework has become a key task for safeguarding research integrity and maintaining trust within the academic community.This expert consensus outlines ethical requirements across key stages of AI-assisted academic writing-including topic selection,data management,citation practices,and authorship attribution.It aims to clarify the boundaries and ethical obligations surrounding AI use in academic writing,ensuring that technological tools enhance efficiency without compromising in-tegrity.The goal is to provide guidance and institutional support for building a responsible and sustainable research ecosystem.

Objective: To evaluate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating tumor deposits (TDs) from metastatic lymph nodes (MLNs) in rectal cancer. Materials and Methods: A retrospective analysis was conducted on 70 patients with rectal cancer, including 168 lesions (70 TDs and 98 MLNs confirmed by histopathology), who underwent pretreatment MRI and subsequent surgery between March 2019 and December 2022. The morphological characteristics of TDs and MLNs, along with quantitative parameters derived from DCE-MRI (K trans , kep, and v e) and DWI (ADCmin, ADCmax, and ADCmean), were analyzed and compared between the two groups.Multivariable binary logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of significant individual quantitative parameters and combined parameters in distinguishing TDs from MLNs. Results: All morphological features, including size, shape, border, and signal intensity, as well as all DCE-MRI parameters showed significant differences between TDs and MLNs (all P < 0.05). However, ADC values did not demonstrate significant differences (all P > 0.05). Among the single quantitative parameters, v e had the highest diagnostic accuracy, with an area under the ROC curve (AUC) of 0.772 for distinguishing TDs from MLNs. A multivariable logistic regression model incorporating short axis, border, v e, and ADC mean improved diagnostic performance, achieving an AUC of 0.833 (P = 0.027). Conclusion The combination of morphological features, DCE-MRI parameters, and ADC values can effectively aid in the preoperative differentiation of TDs from MLNs in rectal cancer.

Cemental tear is a rare and indetectable condition unless obvious clinical signs present with the involvement of surrounding periodontal and periapical tissues. Due to its clinical manifestations similar to common dental issues, such as vertical root fracture, primary endodontic diseases, and periodontal diseases, as well as the low awareness of cemental tear for clinicians, misdiagnosis often occurs. The critical principle for cemental tear treatment is to remove torn fragments, and overlooking fragments leads to futile therapy, which could deteriorate the conditions of the affected teeth. Therefore, accurate diagnosis and subsequent appropriate interventions are vital for managing cemental tear. Novel diagnostic tools, including cone-beam computed tomography (CBCT), microscopes, and enamel matrix derivatives, have improved early detection and management, enhancing tooth retention. The implementation of standardized diagnostic criteria and treatment protocols, combined with improved clinical awareness among dental professionals, serves to mitigate risks of diagnostic errors and suboptimal therapeutic interventions. This expert consensus reviewed the epidemiology, pathogenesis, potential predisposing factors, clinical manifestations, diagnosis, differential diagnosis, treatment, and prognosis of cemental tear, aiming to provide a clinical guideline and facilitate clinicians to have a better understanding of cemental tear.
Humans ; Dental Cementum/injuries* ; Consensus ; Diagnosis, Differential ; Cone-Beam Computed Tomography ; Tooth Fractures/therapy*

Objective: To evaluate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating tumor deposits (TDs) from metastatic lymph nodes (MLNs) in rectal cancer. Materials and Methods: A retrospective analysis was conducted on 70 patients with rectal cancer, including 168 lesions (70 TDs and 98 MLNs confirmed by histopathology), who underwent pretreatment MRI and subsequent surgery between March 2019 and December 2022. The morphological characteristics of TDs and MLNs, along with quantitative parameters derived from DCE-MRI (K trans , kep, and v e) and DWI (ADCmin, ADCmax, and ADCmean), were analyzed and compared between the two groups.Multivariable binary logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of significant individual quantitative parameters and combined parameters in distinguishing TDs from MLNs. Results: All morphological features, including size, shape, border, and signal intensity, as well as all DCE-MRI parameters showed significant differences between TDs and MLNs (all P < 0.05). However, ADC values did not demonstrate significant differences (all P > 0.05). Among the single quantitative parameters, v e had the highest diagnostic accuracy, with an area under the ROC curve (AUC) of 0.772 for distinguishing TDs from MLNs. A multivariable logistic regression model incorporating short axis, border, v e, and ADC mean improved diagnostic performance, achieving an AUC of 0.833 (P = 0.027). Conclusion The combination of morphological features, DCE-MRI parameters, and ADC values can effectively aid in the preoperative differentiation of TDs from MLNs in rectal cancer.

Objective: To evaluate the feasibility of dynamic contrast-enhanced MRI (DCE-MRI) in differentiating tumor deposits (TDs) from metastatic lymph nodes (MLNs) in rectal cancer. Materials and Methods: A retrospective analysis was conducted on 70 patients with rectal cancer, including 168 lesions (70 TDs and 98 MLNs confirmed by histopathology), who underwent pretreatment MRI and subsequent surgery between March 2019 and December 2022. The morphological characteristics of TDs and MLNs, along with quantitative parameters derived from DCE-MRI (K trans , kep, and v e) and DWI (ADCmin, ADCmax, and ADCmean), were analyzed and compared between the two groups.Multivariable binary logistic regression and receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic performance of significant individual quantitative parameters and combined parameters in distinguishing TDs from MLNs. Results: All morphological features, including size, shape, border, and signal intensity, as well as all DCE-MRI parameters showed significant differences between TDs and MLNs (all P < 0.05). However, ADC values did not demonstrate significant differences (all P > 0.05). Among the single quantitative parameters, v e had the highest diagnostic accuracy, with an area under the ROC curve (AUC) of 0.772 for distinguishing TDs from MLNs. A multivariable logistic regression model incorporating short axis, border, v e, and ADC mean improved diagnostic performance, achieving an AUC of 0.833 (P = 0.027). Conclusion The combination of morphological features, DCE-MRI parameters, and ADC values can effectively aid in the preoperative differentiation of TDs from MLNs in rectal cancer.