Objective To investigate the predictive value of thromboelastography(TEG)combined with mean platelet volume(MPV)in patients with ischemic stroke after dual antiplatelet therapy.Methods A to-tal of 130 cases with ischemic stroke who received dual antiplatelet therapy in the hospital from November 2021 to December 2023 were selected as the study subjects.According to the results of follow-up 6 months af-ter treatment,they were divided into non-recurrence group(n=98)and recurrence group(n=32).Venous blood was collected from all patients for TEG and MPV tests.TEG parameters[coagulation reaction time(R),clot formation time(K),hemagglutination rate(α angle),maximum clot intensity(MA value),compos-ite index(CI)]and MPV of the two groups were compared.The predictive value of TEG combined with MPV for postoperative recurrence of patients was analyzed by receiver operating characteristic(ROC)curve.Multi-variate Logistic regression analysis was used to explore the influencing factors of relapse.Results R and K in recurrence group were lower than those in non-recurrence group,α angle,MA value,CI and MPV were higher than those in non-relapsed group,with statistical significance(P＜0.05).ROC curve analysis showed that the area under curve of the combined prediction of α angle,MA value,and MPV for recurrence after dual antiplate-let therapy in ischemic stroke patients was 0.938,which was higher than predicted separately(Z=9.983,6.711,5.036,all P＜0.001).The proportions of smoking history,atrial fibrillation,diabetes and deep vein thrombosis in relapse group were higher than those in non-recurrence group(P＜0.05).Multivariate Logistic regression analysis showed that diabetes mellitus,α Angle ≥69.39°,MA value ≥67.07 mm,MPV≥10.39 fL were all risk factors for recurrence after dual antiplatelet therapy in ischemic stroke patients(P＜0.05).Con-clusion The α angle of thrombologram,MA value and MPV can be used as important indicators to predict the recurrence of patients with ischemic stroke after dual antiplatelet therapy,and the combined application of the three is more effective.

Objective To study the distribution characteristics of blood uric acid level and blood glucose status and their potential interaction in elderly hypertensive patients. Methods The randomized study enrolled elderly patients with essential hypertension who were treated in our hospital from January 2020 to January 2022 and received antihypertensive therapy. Collected patients’ sociodemographic information, medical history, treatment history, etc., and detected their blood uric acid and blood glucose levels. Analyzed and described the subjects’ basic characteristics and the distribution of blood uric acid and blood glucose, and the potential interaction between them. Results A total of 205 subjects were included in this study, including 108 males and 97 females, with an average age of 70.94 years and an average BMI of 23.19kg/m². During the study period, the average blood pressure level was controlled at SBP 151.34±10.96mmHg and DBP 96.24±9.87mmHg, and the proportion of excellent blood pressure control reached 89.27%. The blood uric acid level of the subjects was elevated by increasing of subjects' age and BMI (P < 0.05), and blood glucose only elevated by the increasing of BMI (P < 0.001). High BMI, high DBP, family history of hypertension, high blood uric acid level, and current history of diabetes were risk factors for elevated hypertension grade. Conclusions High DBP, high BMI, high blood uric acid level, current history of diabetes and family history of hypertension are risk factors in elderly hypertensive patients, we could make clinical treatment strategies for these patients accordingly.