Objective:To explore the research hotspots and frontiers in the field of brain injury after carbon monoxide（CO）poisoning by visual analytic approach.Methods:The research literature on brain injury after CO poisoning，published from 2011 to 2020，were retrieved from the Web of Science（core collection）. The publish years of the literature were statistically analyzed，and the burst detection of key words and co-citation analysis were made by the visual analytic software CiteSpace，in order to find out research hotspots and frontiers in the field of brain injury after CO poisoning.Results:A total of 242 papers on brain injury after CO poisoning were retrieved. The cumulative frequencies of annually publication volume on brain injury after CO poisoning from 2011 to 2020 showed an exponential growth. The burst detection of key words showed that emergency department，hyperbaric oxygen therapy，and globus pallidus were the three research hotspots in this field. The co-citation analysis showed that the papers related to hyperbaric oxygen therapy were the most active，and the papers on hyperbaric oxygen therapy were closely related to those on rats in recent years，reflecting the research frontier and trend of the study on brain injury after CO poisoning.Conclusion:Brain injury after CO poisoning may involve immune response caused by structural changes of myelin basic proteins. It is the future research trend to study the pathophysiological mechanism of brain injury after CO poisoning through animal models and to investigate the clinical efficacy of hyperbaric oxygen therapy on such injuries.

Objective:To explore the research hotspots and frontiers in the field of brain injury after carbon monoxide（CO）poisoning by visual analytic approach.Methods:The research literature on brain injury after CO poisoning，published from 2011 to 2020，were retrieved from the Web of Science（core collection）. The publish years of the literature were statistically analyzed，and the burst detection of key words and co-citation analysis were made by the visual analytic software CiteSpace，in order to find out research hotspots and frontiers in the field of brain injury after CO poisoning.Results:A total of 242 papers on brain injury after CO poisoning were retrieved. The cumulative frequencies of annually publication volume on brain injury after CO poisoning from 2011 to 2020 showed an exponential growth. The burst detection of key words showed that emergency department，hyperbaric oxygen therapy，and globus pallidus were the three research hotspots in this field. The co-citation analysis showed that the papers related to hyperbaric oxygen therapy were the most active，and the papers on hyperbaric oxygen therapy were closely related to those on rats in recent years，reflecting the research frontier and trend of the study on brain injury after CO poisoning.Conclusion:Brain injury after CO poisoning may involve immune response caused by structural changes of myelin basic proteins. It is the future research trend to study the pathophysiological mechanism of brain injury after CO poisoning through animal models and to investigate the clinical efficacy of hyperbaric oxygen therapy on such injuries.

Objective To make a systematical review of the efficacy and safety of endoscopic variceal ligation versus endoscopic variceal sclerotherapy for treatment of esophageal variceal bleeding. Methods We electronically searched databases including PubMed, Web of Science, The Cochrane Library (Issue 2, 2016), CNKI, WanFang Data and from Jan., 1980, to Mar., 2015, collected randomized controlled trials (RCTs) about EVL versus EVS for the patients of esophageal variceal bleeding. Then, meta-analysis was performed using RevMan 5.3 software. Results A total of 24 studies including 2020 patients were included. The results of meta-analysis showed that, there were no signiifcant differences in the variceal eradication rate (RR=1.04, 95%CI 0.99 to 1.09, P=0.090) between the EVL group and the EVS group; Compared with the EVS group, the EVL group could significantly reduce the rate of variceal rebleeding (RR=0.69, 95%CI 0.59 to 0.81, P=0.000), the rate of mortality (RR=0.76, 95%CI 0.63 to 0.90, P=0.002) and the rate of complication (RR=0.41, 95%CI 0.26 to 0.63, P=0.000), but the rate of variceal recurrent rate of EVS group was lower than that of the EVL group (RR=1.67, 95%CI 1.40 to 2.01,P=0.000). Conclusion Current evidence shows that, the variceal eradication rate between EVL and EVS is similar, but the EVL has less incidence of variceal rebleeding and mortality and complication.