Objective:To explore the effectiveness of predictive exercise intervention combined with information-knowledge-attitude-practice (IKAP) model-based nursing in patients with gestational hypertension (GH) .Methods:Convenience sampling was used to select 130 GH patients admitted to Taizhou Hospital of Zhejiang Province from January 2022 to December 2024 for the study. Sixty-five GH patients admitted from January 2022 to June 2023 were set as control group, and 65 GH patients admitted from July 2023 to December 2024 were set as observation group. Control group implemented conventional nursing, and observation group was treated with predictive exercise intervention combined with IKAP model-based nursing on the basis of conventional nursing. Depression, delivery outcomes, and incidence of complications were compared between two groups of GH patients after intervention.Results:During the study period, no patients were excluded from observation group and one patient was withdrawn from control group for personal reasons, resulting in the inclusion of 64 patients. Patients in observation group at 6 weeks postpartum had lower scores on the Chinese version of the Edinburgh Postnatal Depression Scale than those in control group, and the incidence of premature labor, cesarean section, and lower limb swelling were lower than those in control group, and the differences were all statistically significant ( P<0.05) . Conclusions:Predictive exercise intervention combined with IKAP model-based nursing can improve the coagulation function of GH patients, reduce the incidence of lower limb swelling, alleviate the patient's postpartum depression, and facilitate safe delivery.

Objective:To explore the effectiveness of predictive exercise intervention combined with information-knowledge-attitude-practice (IKAP) model-based nursing in patients with gestational hypertension (GH) .Methods:Convenience sampling was used to select 130 GH patients admitted to Taizhou Hospital of Zhejiang Province from January 2022 to December 2024 for the study. Sixty-five GH patients admitted from January 2022 to June 2023 were set as control group, and 65 GH patients admitted from July 2023 to December 2024 were set as observation group. Control group implemented conventional nursing, and observation group was treated with predictive exercise intervention combined with IKAP model-based nursing on the basis of conventional nursing. Depression, delivery outcomes, and incidence of complications were compared between two groups of GH patients after intervention.Results:During the study period, no patients were excluded from observation group and one patient was withdrawn from control group for personal reasons, resulting in the inclusion of 64 patients. Patients in observation group at 6 weeks postpartum had lower scores on the Chinese version of the Edinburgh Postnatal Depression Scale than those in control group, and the incidence of premature labor, cesarean section, and lower limb swelling were lower than those in control group, and the differences were all statistically significant ( P<0.05) . Conclusions:Predictive exercise intervention combined with IKAP model-based nursing can improve the coagulation function of GH patients, reduce the incidence of lower limb swelling, alleviate the patient's postpartum depression, and facilitate safe delivery.

Objective To observe the value of reduced field-of-view(rFOV)diffusion weighted imaging(DWI)for differentiating low-risk and high-risk thymoma.Methods A total of 145 patients with pathologically confirmed thymoma were retrospectively collected,among them there were 96 cases of low-risk thymoma(low-risk group,including 33 cases of type A,29 cases of type AB and 34 cases of type B1 thymoma)and 49 cases of high-risk thymoma(high-risk group,including 26 cases of type B2 and 23 cases of type B3 thymoma).Conventional single-shot echo planar imaging(SSEPI)and ZOOMit sequence DWI before treatment were compared,and subjective scoring based on displaying of anatomical structures,thymoma lesions,image artifacts and overall diagnosis confidence were performed,so did objective evaluation according to image signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR)of 2 kinds of images.The apparent diffusion coefficient(ADC)obtained with DWI were compared between groups.Receiver operating characteristic(ROC)curve was drawn,and area under the curve(AUC)was calculated to analyze the efficacy of ADC for differentiating low-risk and high-risk thymoma.Results Subjective scores of displaying anatomical structures,thymoma lesions,image artifacts and overall diagnosis confidence of ZOOMit were all superior to those of SSEPI(all P＜0.001),while SNR and CNR of ZOOMit were both higher than those of SSEPI(all P＜0.001).There were statistical differences of ADCSSEPI and ADCZOOMit between groups(both P＜0.001).The AUC of ADCssEPI and ADCZOOMit for distinguishing low-risk and high-risk thymoma was 0.865 and 0.922,respectively,of the former was higher than of the latter(Z=2.091,P=0.037).Conclusion rFOV DWI could be used to differentiate low-risk and high-risk thymoma.

Objective To observe the value of reduced field-of-view(rFOV)diffusion weighted imaging(DWI)for differentiating low-risk and high-risk thymoma.Methods A total of 145 patients with pathologically confirmed thymoma were retrospectively collected,among them there were 96 cases of low-risk thymoma(low-risk group,including 33 cases of type A,29 cases of type AB and 34 cases of type B1 thymoma)and 49 cases of high-risk thymoma(high-risk group,including 26 cases of type B2 and 23 cases of type B3 thymoma).Conventional single-shot echo planar imaging(SSEPI)and ZOOMit sequence DWI before treatment were compared,and subjective scoring based on displaying of anatomical structures,thymoma lesions,image artifacts and overall diagnosis confidence were performed,so did objective evaluation according to image signal-to-noise ratio(SNR)and contrast-to-noise ratio(CNR)of 2 kinds of images.The apparent diffusion coefficient(ADC)obtained with DWI were compared between groups.Receiver operating characteristic(ROC)curve was drawn,and area under the curve(AUC)was calculated to analyze the efficacy of ADC for differentiating low-risk and high-risk thymoma.Results Subjective scores of displaying anatomical structures,thymoma lesions,image artifacts and overall diagnosis confidence of ZOOMit were all superior to those of SSEPI(all P＜0.001),while SNR and CNR of ZOOMit were both higher than those of SSEPI(all P＜0.001).There were statistical differences of ADCSSEPI and ADCZOOMit between groups(both P＜0.001).The AUC of ADCssEPI and ADCZOOMit for distinguishing low-risk and high-risk thymoma was 0.865 and 0.922,respectively,of the former was higher than of the latter(Z=2.091,P=0.037).Conclusion rFOV DWI could be used to differentiate low-risk and high-risk thymoma.

To investigate the effects of interleukin (IL)-17-mediated autophagy on the TNF receptor associated factor (TRAF6)/extracellular signal-regulated kinase (ERK)/p38 pathway and osteoclast differentiation. Mouse bone marrow-derived macrophages (BMM) were cultured with a medium containing 30 ng/mL macrophage colony stimulating factor and 50 ng/mL receptor activator of nuclear factor-kappa B ligard (RANKL), and IL-17 (0.01, 0.1, 1.0, 10 ng/mL) was added for intervention (IL-17 group). Tartrate-resistant acid phosphatase (TRAP) staining was used to observe TRAP positive multinucleated cells; phalloidin fluorescent staining was used to detect actin ring circumference; toluidine blue staining was used to analyze bone resorption lacuna formation. To further examine the mechanism of the effect of IL-17-mediated autophagy on the differentiation of osteoclasts, the control group used RANKL medium to culture mouse macrophage RAW264.7 cells, while the IL-17 group was treated with IL-17 (0.01, 0.1, 1.0, /mL). Western blot was used to detect the expression of autophagy-related proteins Beclin-1, microtubule-associated protein 1 light chain 3 (LC3) and osteoclast-related proteins c-fos and nuclear factor of activated T cell 1 (NFATc1) after treatment with different concentrations of IL-17. The expression of LC3, NFATc1, TRAF6/ERK/p38 signaling pathway related proteins were detected in IL-17 and autophagy inhibitor 3-MA group. The number of TRAP positive multinucleated cells, the circumference of the actin ring and the area of bone resorption lacuna in IL-17 group treated with IL-17 (0.01, 0.1, were significantly higher than those in the control group. In IL-17 treated RAW264.7 cells, the expression of c-fos, NFATc1, Beclin-1, LC3, TRAF6, p-ERK, and p-p38 was all significantly up-regulated (all 0.05). After treatment with the autophagy inhibitor 3-MA, the expression levels of LC3, NFATc1, TRAF6, p-ERK, and p-p38 all decreased significantly (all 0.05). IL-17 can promote the expression of autophagy proteins and enhance the differentiation ability of osteoclast precursor cells, and the TRAF6/ERK/p38 signaling pathway may be involved in this process.
Animals ; Autophagy ; Bone Resorption ; Cell Differentiation ; Extracellular Signal-Regulated MAP Kinases ; Interleukin-17 ; Mice ; NFATC Transcription Factors/metabolism* ; Osteoclasts/metabolism* ; RANK Ligand/metabolism* ; TNF Receptor-Associated Factor 6