OBJECTIVE To evaluate the quality of Yindan huoxue tongyu granules. METHODS Taking high performance liquid chromatography with ultraviolet and evaporative light scattering detection as method， the fingerprint of 15 batches of Yindan huoxue tongyu granules was established， and similarity evaluation was performed by Similarity Evaluation System of Chromatographic Fingerprint of TCM （2012 edition） to determine common peaks. The common peaks were identified by comparing with reference substance chromatograms and single decoction piece chromatograms. Network pharmacology was used to screen out core targets and pathways of identified components， construct a “component-target-pathway” network diagram， and predict the pharmacodynamic components of Yindan huoxue tongyu granules， and the content determination of these components was carried out by the same method. RESULTS HPLC fingerprints of 15 batches of Yindan huoxue tongyu granules were characterized with 40 common peaks， and 17 components including salvianolic acid B， astragaloside Ⅳ， notoginsenoside R1， and ginkgolide A were identified. Network pharmacology predicted that 17 components mainly acted on 97 core targets and 137 pathways to exert their pharmacological effect. Average contents of 13 bioactive components in 15 batches of samples were 0.126 8， 0.232 0， 0.073 8， 0.353 2， 3.620 2， 0.191 0， 0.333 3， 0.317 4， 0.785 0， 0.538 2， 0.460 0， 2.475 1 and 0.347 7 mg/g， including calycosin-7-O-β-D-glucoside， rosmarinic acid， formononetin， lithospermic acid， salvianolic acid B， ononin， ginsenoside Rb1， ginsenoside Rd， ginkgolide C， ginkgolide A， ginkgolide B， notoginsenoside R1， and astragaloside Ⅳ. CONCLUSIONS The established fingerprint of Yindan huoxue tongyu granules can reflect the overall characteristics of the preparation. The content determination method for its pharmacodynamic components， developed in combination with network pharmacology， is accurate， reliable， and exhibits good repeatability， making it suitable for evaluating the quality of Yindan huoxue tongyu granules.

Objective:To investigate the mediating role of psychological capital between the perception of decent work and work engagement among Operating Room nurses, and to provide insights for improving their work engagement.Methods:From December 2023 to February 2024, a total of 307 Operating Room nurses from four class ⅢGrade A hospitals in Beijing, Chongqing, Dalian, and Zhuhai were recruited using convenience sampling. Data were collected using a general information questionnaire, Work Engagement Scale, Decent Work Scale, and Nurses' Psychological Capital Scale. Pearson correlation analysis was conducted to examine the relationships among psychological capital, perception of decent work, and work engagement. Structural equation modeling and mediation analysis were performed using AMOS 24.0 software.Results:A total of 307 questionnaires were distributed, and 301 valid responses were collected, with an effective response rate of 98.05%. The mean scores for work engagement, perception of decent work, and psychological capital were (41.01±10.76), (67.30±17.86), and (93.30±15.15), respectively. Work engagement was positively correlated with both the perception of decent work and psychological capital (all P<0.01), and the perception of decent work was positively correlated with psychological capital ( P<0.01). Psychological capital partially mediated the relationship between the perception of decent work and work engagement, with the mediating effect accounting for 62.63%. Conclusions:Psychological capital plays a partial mediating role between the perception of decent work and work engagement among Operating Room nurses. Nursing managers can enhance nurses' work engagement by improving their perception of decent work and strengthening their psychological capital.

Objective To explore changes of topological properties and functional connectivity(FC)of global brain network in breast cancer(BC)patients accompanied by emotional disorders.Methods Forty-three female BC patients(BC group)and 43 age-and education-matched healthy controls(HC group)were prospectively enrolled.The scores of fear of cancer recurrence-total(FCR-total),fear of cancer recurrence inventory(FCRI),general anxiety disorder-7(GAD-7)and patient health questionnaire-9(PHQ-9)for 43 patients in BC group,as well as of anxiety sensitivity index-3(ASI-3),meta-cognitions about health questionnaire(MCQ-HA)and EuroQoL 5-dimension 5-level questionnaire(EQ-5D-5L)for 40 patients in BC group were obtained to evaluate emotional disorders.Meanwhile,the scores of GAD-7 and PHQ-9 were obtained in HC group to exclude for anxiety and depression.Using resting-state functional MRI(rs-fMRI),topological attributes and FC of global brain network were analyzed,and the topological attribute indicators of global brain network were compared between groups.Based on voxel-wise analysis,the regions in global brain related to FC strength(FCS)correlated with each clinical scale score in BC group were analyzed,and spatial similarity analysis of FCS was performed.The correlations of FCS at brain region level and clinical scale scores in BC group were observed.Results All patients in BC group were accompanied by emotional disorders.The clustering coefficient in BC group was lower than that in HC group(t=-2.261,P=0.027).Brain regions related to FCS values correlated with each clinical scale score in BC group were widely distributed in sensorimotor network and higher-order brain network,etc.,and their FCS values were correlated.FCS of ventrolateral nucleus of right thalamus and caudate nucleus were positively correlated with FCR-total(r=0.459,P=0.004)and FCRI(r=0.488,P=0.005).Conclusion BC patients with emotions disorders had dysfunction of brain functional segregation,as well as enhanced FCS in brain regions such as ventrolateral nucleus of right thalamus and caudate nucleus.

Objective To explore changes of topological properties and functional connectivity(FC)of global brain network in breast cancer(BC)patients accompanied by emotional disorders.Methods Forty-three female BC patients(BC group)and 43 age-and education-matched healthy controls(HC group)were prospectively enrolled.The scores of fear of cancer recurrence-total(FCR-total),fear of cancer recurrence inventory(FCRI),general anxiety disorder-7(GAD-7)and patient health questionnaire-9(PHQ-9)for 43 patients in BC group,as well as of anxiety sensitivity index-3(ASI-3),meta-cognitions about health questionnaire(MCQ-HA)and EuroQoL 5-dimension 5-level questionnaire(EQ-5D-5L)for 40 patients in BC group were obtained to evaluate emotional disorders.Meanwhile,the scores of GAD-7 and PHQ-9 were obtained in HC group to exclude for anxiety and depression.Using resting-state functional MRI(rs-fMRI),topological attributes and FC of global brain network were analyzed,and the topological attribute indicators of global brain network were compared between groups.Based on voxel-wise analysis,the regions in global brain related to FC strength(FCS)correlated with each clinical scale score in BC group were analyzed,and spatial similarity analysis of FCS was performed.The correlations of FCS at brain region level and clinical scale scores in BC group were observed.Results All patients in BC group were accompanied by emotional disorders.The clustering coefficient in BC group was lower than that in HC group(t=-2.261,P=0.027).Brain regions related to FCS values correlated with each clinical scale score in BC group were widely distributed in sensorimotor network and higher-order brain network,etc.,and their FCS values were correlated.FCS of ventrolateral nucleus of right thalamus and caudate nucleus were positively correlated with FCR-total(r=0.459,P=0.004)and FCRI(r=0.488,P=0.005).Conclusion BC patients with emotions disorders had dysfunction of brain functional segregation,as well as enhanced FCS in brain regions such as ventrolateral nucleus of right thalamus and caudate nucleus.

Objective:To investigate the mediating role of psychological capital between the perception of decent work and work engagement among Operating Room nurses, and to provide insights for improving their work engagement.Methods:From December 2023 to February 2024, a total of 307 Operating Room nurses from four class ⅢGrade A hospitals in Beijing, Chongqing, Dalian, and Zhuhai were recruited using convenience sampling. Data were collected using a general information questionnaire, Work Engagement Scale, Decent Work Scale, and Nurses' Psychological Capital Scale. Pearson correlation analysis was conducted to examine the relationships among psychological capital, perception of decent work, and work engagement. Structural equation modeling and mediation analysis were performed using AMOS 24.0 software.Results:A total of 307 questionnaires were distributed, and 301 valid responses were collected, with an effective response rate of 98.05%. The mean scores for work engagement, perception of decent work, and psychological capital were (41.01±10.76), (67.30±17.86), and (93.30±15.15), respectively. Work engagement was positively correlated with both the perception of decent work and psychological capital (all P<0.01), and the perception of decent work was positively correlated with psychological capital ( P<0.01). Psychological capital partially mediated the relationship between the perception of decent work and work engagement, with the mediating effect accounting for 62.63%. Conclusions:Psychological capital plays a partial mediating role between the perception of decent work and work engagement among Operating Room nurses. Nursing managers can enhance nurses' work engagement by improving their perception of decent work and strengthening their psychological capital.

Objective:To systematically retrieve, evaluate, and summarize evidence on insomnia screening and assessment in adult malignant tumor patients.Methods:The clinical decisions, guidelines, and expert consensus on screening and assessing insomnia in malignant tumor patients were systematically searched in clinical decision support systems, guideline websites, literature databases, and professional association websites. This study conducted methodological quality evaluation and evidence extraction, translation, and integration.Results:A total of 8 articles were included, including three clinical decisions, two evidence-based guidelines, and three expert consensuses. After extracting and summarizing evidence, 38 pieces of evidence were obtained from three aspects of general management principles, insomnia screening, and insomnia assessment.Conclusions:The insomnia screening and assessment in adult malignant tumor patients should be standardized according to evidence-based standards and combined with specific clinical situations in China.

Objective: To analyze the differences in low-frequency fluctuations (fALFF) between patients with schizophrenia (SC) and healthy controls so as to further explore the pathogenesis of schizophrenia by correlating with clinical symptoms and inflammatory cytokines. Methods: We recruited 38 SC patients and 35 demographically matched healthy subjects. Serum levels of inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA). Clinical symptoms were assessed by the Positive and Negative Symptoms Scale (PANSS). After high-resolution fMRI scanning, data processing and analysis for brain imaging (DPABI) was used to find potential differences in fALFF between the two groups. A Pearson correlation model was used to analyze the associations of functional changes with clinical symptoms and inflammatory cytokines. DPABI software and SPSS 22.0 software were used for data analysis and GRF (P<0.05) theory for multiple comparison correction. Results: ① Compared to the healthy controls, SC patients had significantly increased fALFF values in the bilateral putamen and the right cingulum, but decreased fALFF values in the left precuneus and the left superior frontal gyrus. ② The levels of TNF-α, CCL2, IL-β, IL-4, IL-6 and IL-8 were significantly higher in SC group than in the control group (z=-3.301, P=0.001; z=-3.053, P=0.002; z=-5.429, P<0.001; z=-6.562, P<0.001; z=-4.537, P<0.001; z=-2.153, P=0.031). ③ The fALFF values of the left putamen of SC group were significantly correlated with the total scores of PANSS (Left: r=0.409, P=0.025; Right: r=0.428, P=0.019). The fALFF values of the left precuneus of SC group were significantly correlated with the levels of IL-4 (r=-0.412, P=0.026); the fALFF values of right cingulum of SC group were significantly correlated with the levels of TNF-α (r=0.392, P=0.035). Conclusion: Abnormalities in inflammatory cytokines and partial brain regions are found in SC patients. More importantly, the left putamen and the right cingulum are associated with disease symptoms and inflammatory cytokines, suggesting that these regions play an important role in the pathogenesis of SC.

Objective To investigate the difference of Wechsler's cognitive test and its influencing factors in first-episode depression patients with and without sleep disorder.Methods 156 patients with de-pression were divided into two groups according to their sleep conditions,including sleep disorder group(n=77)and non-sleep disorder group(n=79).Wechsler Intelligence Scale(WAIS)and Wechsler Memory Scale(WMS)were used to assess the cognitive function,while Hamilton Depression Scale(HAMD-17) were used to assess depressive symptoms.Results (1)Sleep disorders group had lower scores on verbal IQ (95.51±16.45),performance IQ(90.94±13.87),FIQ scores(92.48±15.49)than those in the non-sleep disorder group((105.59±15.20),(96.19±13.62),(101.20±14.70)respectively),the differences were statistically significant(P<0.05).Sleep disorder group had lower scores in immediate memory(10.47 ± 3.88),short-term memory(49.87±14.35)and memory quotient(87.90±18.25)than those in the non-sleep disorder group((11.86±3.47),(56.52±13.03),(97.27±18.76)respectively),the differences were statisti-cally significant(all P<0.05).(2)Multivariate linear regression analysis showed that education and age ex-plained 24% of variance in verbal IQ(F=21.258,P<0.01).Education,sleep disorder factors explained 12.9% of variation in performance IQ(F=9.825,P<0.01).Education,sleep disorder factors explained 22.3% of variance in total IQ(F=22.847,P<0.01).Education,age,sleep disorder factors explained 28.4%of variation in short-term memory(F=23.850,P<0.01).Education and age explained 20.4% of variation in immediate memory(F=18.10,P<0.01).Education and sleep disorder factors explained 21.9% of variation in memory quotient(F=26.162,P<0.01).Conclusion The intelligence and memory impairment in first-epi-sode depression patients with sleep disorders is more serious,and the education,sleep disorder and age are the most important factors.

Objective To effectively combine the results of resting state regional homogeneity(ReHo) fMRI studies in depression.Methods Literatures between 2003-2016 on fMRI of depression in PubMed,Web of Knowledge,EBSCO host medline,CNKI,CQVIP and Wanfang Med Online were taken as research objects.Screening the relevant data according to the included and excluded standard,then,software of AES-SDM was employed to do Meta analysis,in addition,the age,gender,duration of disease,the year of education and treatment were also analyzed.Results 23 articles met the standard,including 1 036 cases,of which 507 for the depression group,529 for the control group.Meta analysis showed the significant ReHo abnormalities of Default Mode Network(DMN) which centers on left precuneus,left superior frontal gyrus and right cingulate gyrus,in addition,left lenticular nucleus,left postcentral gyrus,left cerebellum and left fusiform gyrus had significant ReHo differences.In the regression analysis,gender,age,duration of disease,years of education,disease severity were all affected factors.The difference of cingulate gyrus was the most stable,and the duration of the disease significantly affected cingulate gyrus (SDM =2.777).Conclusion The abnormalities of DMN which centers on left precuneus,left,medial superior frontal gyrus and right cingulate gyrus are the most consistent in depression,the DMN is closely related to depression.

Objective To investigate the value of end-tidal carbon dioxide partial pressure (PET CO2 )in fluid resuscitation in severe acute pancreatitis(SAP)patients.Methods SAP patients under mechanical ventilation with the need of a fluid challenge test were included.Hemodynamic parameter cardiac index(CI)and PET CO2 were conducted before and after the fluid challenge test.The value of ΔPET CO2 was used to predict fluid responsiveness. Results Totally 43 patients with SAP were prospectively recruited.31 patients had volume responsiveness, 12 patients had no volume responsiveness.Compared with no volume responsiveness group,volume responsiveness group led to a greater increase in ΔCI[(0.9 ±0.3)vs.(0.2 ±0.3),t =3.24,P <0.05]and ΔPET CO2 [(4.1 ± 1.9)vs.(0.7 ±1.2),t =4.01,P <0.05].ΔPET CO2 and ΔCI were correlated(r =0.74,P <0.05).The area under ROC curve of ΔPET CO2 was 0.872(95% CI 0.754 ~0.923,P <0.05).An increase of 5% in ΔPET CO2 predicted fluid responsiveness with a sensitivity of 86.7%,and specificity of 89.5%.Conclusion The change of ΔPET CO2 induced by fluid challenge test is an effective way to predict fluid responsiveness in SAP patients.