BACKGROUND:Siblings family protein is an exocrine protein family,which can be secreted into the extracellular matrix by a variety of cells and is adhered to extracellular matrix collagen,and in turn it will act on the cells,resulting in corresponding physiological and pathological effects.OBJECTIVE:To summarize the current research on the effects of Siblings family protein on cardiovascular diseases.METHODS:The relevant literature was searched in PubMed,Web of Science,Engineering Village and CNKI databases by computer from January 2008 to March 2024.The search terms were"Current research status,Siblings,Siblings protein family,Cardiovascular,Cardiovascular diseases"in Chinese and English.According to the inclusion criteria,search results were screened and excluded,and finally 76 papers were included for review and analysis.RESULTS AND CONCLUSION:(1)Siblings family proteins play a significant role in various cardiovascular diseases,which has great research potentials especially in valvular calcification and vascular sclerosis.(2)Some Siblings family proteins can deposit calcium salts to form hydroxyapatite core that starts to form microcalcification nodules.Moreover,they can promote positive feedback mechanism of osteoblast-like differentiation by binding RGD peptide and integrin receptors on the cell surface,and increase the expression of Siblings family proteins.(3)Integrin receptor can be a potential target for the treatment of cardiovascular calcification diseases.Clinically,calcification process can be delayed by blocking integrin receptor.

BACKGROUND:Siblings family protein is an exocrine protein family,which can be secreted into the extracellular matrix by a variety of cells and is adhered to extracellular matrix collagen,and in turn it will act on the cells,resulting in corresponding physiological and pathological effects.OBJECTIVE:To summarize the current research on the effects of Siblings family protein on cardiovascular diseases.METHODS:The relevant literature was searched in PubMed,Web of Science,Engineering Village and CNKI databases by computer from January 2008 to March 2024.The search terms were"Current research status,Siblings,Siblings protein family,Cardiovascular,Cardiovascular diseases"in Chinese and English.According to the inclusion criteria,search results were screened and excluded,and finally 76 papers were included for review and analysis.RESULTS AND CONCLUSION:(1)Siblings family proteins play a significant role in various cardiovascular diseases,which has great research potentials especially in valvular calcification and vascular sclerosis.(2)Some Siblings family proteins can deposit calcium salts to form hydroxyapatite core that starts to form microcalcification nodules.Moreover,they can promote positive feedback mechanism of osteoblast-like differentiation by binding RGD peptide and integrin receptors on the cell surface,and increase the expression of Siblings family proteins.(3)Integrin receptor can be a potential target for the treatment of cardiovascular calcification diseases.Clinically,calcification process can be delayed by blocking integrin receptor.