Cardiovascular diseases account for 40% of the total mortality in China. Patients′ lifestyle, mental health, medication compliance, and other factors have a significant impact on disease prognosis. The evaluation of left ventricular systolic function is crucial for the diagnosis, treatment, and risk stratification of cardiovascular diseases. Among them, left ventricular global longitudinal strain (LVGLS) is an accurate parameter for evaluating myocardial mechanics based on two-dimensional speckle tracking imaging technology. LVGLS has shown its value in the diagnosis, treatment, and prognosis evaluation of cardiovascular diseases such as heart failure, coronary heart disease, cardiomyopathy, valvular heart disease, and atrial fibrillation. Meanwhile, LVGLS also plays a role in the evaluation of cardiotoxicity related to tumor therapy, providing the possibility of early diagnosis and prevention of disease progression. In conclusion, LVGLS has independent diagnostic and prognostic predictive value in various diseases, and can guide treatment decisions and monitor therapeutic effects. With the advancement of technology and standardization, LVGLS is expected to play a greater role in the management of cardiovascular diseases.

Cardiovascular diseases account for 40% of the total mortality in China. Patients′ lifestyle, mental health, medication compliance, and other factors have a significant impact on disease prognosis. The evaluation of left ventricular systolic function is crucial for the diagnosis, treatment, and risk stratification of cardiovascular diseases. Among them, left ventricular global longitudinal strain (LVGLS) is an accurate parameter for evaluating myocardial mechanics based on two-dimensional speckle tracking imaging technology. LVGLS has shown its value in the diagnosis, treatment, and prognosis evaluation of cardiovascular diseases such as heart failure, coronary heart disease, cardiomyopathy, valvular heart disease, and atrial fibrillation. Meanwhile, LVGLS also plays a role in the evaluation of cardiotoxicity related to tumor therapy, providing the possibility of early diagnosis and prevention of disease progression. In conclusion, LVGLS has independent diagnostic and prognostic predictive value in various diseases, and can guide treatment decisions and monitor therapeutic effects. With the advancement of technology and standardization, LVGLS is expected to play a greater role in the management of cardiovascular diseases.

Objective:To investigate the regression of regional lymph nodes after administering neoadjuvant short-course chemoradiother-apy combined with immunotherapy in patients with locally advanced rectal cancer(LARC).Methods:This retrospective study analyzed the clinical data of 40 patients with LARC admitted to Zhongshan Hospital Affiliated to Xiamen University(32 cases)and the Union Hospital,Tongji Medical College,Huazhong University of Science and Technology(8 cases)between January 2021 and December 2022.The control and experimental groups consisted of 20 patients who underwent direct laparoscopic surgery and neoadjuvant short-course chemoradio-therapy combined with immunotherapy prior to the laparoscopic surgery,respectively.The detection of the postoperative lymph node was compared between the two groups.In addition,the pathologic complete response(pCR)rate of the primary tumor and regional lymph nodes in the experimental group was assessed.Results:The number of patients with N downstaging(18 vs.7,P<0.001)significantly in-creased,whereas the positive lymph node metastasis rate(1.4%vs.19.1%,P<0.001)and number of patients with positive lymph nodes(4 vs.16,P<0.001)significantly decreased in the experimental group compared to those in the control group.Although the number of detected lymph nodes in the experimental group was slightly lower compared to that in the control group(18.3±8.7 vs.20.4±6.5,P=0.392),it was not statistically different.Furthermore,the pCR rate of the regional lymph nodes was significantly higher than that of the primary tumor in the experimental group(80%vs.30%,P=0.001).Conclusions:Neoadjuvant short-course chemoradiotherapy combined with immunotherapy caused significant pathological remission of positive lymph nodes in patients with LARC.This study hypothesizes that a"spatial effect"con-tributes to the pathological remission of regional lymph nodes in rectal tumors.

This paper summarized professor ZHANG Boli's experience in treating stubborn bi （痹） with the herbal pair of Ruxiang （Olibanum）- Moyao （Myrrha）. The basic pathogenesis of stubborn bi is channel and collateral stasis and obstruction. Ruxiang and Moyao are thus used in mutual reinforcement to rectify qi and diffuse bi， activate blood and relieve pain， thereby removing static and obstructed qi and blood， unblocking the obstructed channels and colla-terals， which is especially suitable for stubborn bi caused by channel and collateral obstruction. In clinical practice， the herbal pair of Ruxiang-Moyao is used together with qi-moving and blood-activating medicinals to treat chest bi by expelling stasis and diffusing stagnation， dissipating cold and unblocking vessels. To treat long-term wither and weakness in late stage of stroke， the medicinals of boosting qi and invigorating blood， unblocking channels and venting collaterals can be added to the herbal pair so as to soothe and drain vessels and collaterals， harmonize and regulate qi and blood. Simiao Yongan Decoction （四妙勇安汤） can be integrated in the treatment of vessel bi by moving qi and dissolving stasis， and for the long-term stubborn vessel bi， integrated internal and external treatment is suggested by external use of Ruxiang-Moyao to vent bi with aromatics. Moreover， it is emphasized to use the herbal pair of Ruxiang-Moyao in accordance with indications and cautions.

Cancer research of Chinese medicine has formed some major fields, such as supporting healthy qi, heat clearing-detoxification and eliminating stasis-activating blood, and has made certain achievements. The "theory of anti-tumor effect with wind medicine" described the anti-tumor effects of wind medicine from a new view. In this review, and the relevant research was analyzed comprehensively. The mechanism and superiority of the anti-tumor effect of wind medicine was summarized, and the research problems was also discussed.
Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Neoplasms ; drug therapy