Background: Metabolic syndrome (MetS) has been shown to be associated with multiple factors, including central obesity, insulin resistance, lipid metabolism disorders, and elevated blood pressure, thereby increasing the risk of cardiovascular disease and type 2 diabetes. In recent years, the prevalence of MetS has risen sharply worldwide, affecting about one-third of the global population, becoming a major public health concern. Although several studies on MetS have been conducted in Mongolia, research investigating the relationship between iron metabolism and MetS, particularly among men who are most affected, is limited. This formed the basis for the present study. Aim: To investigate selected indicators of iron metabolism in men with and without MetS. Materials and Methods: A total of 227 men aged 30-60 years from Ulaanbaatar were included in this study. Participants were classified into two groups: MetS (case group) and non-MetS (control group). According to the British Columbia “High Ferritin and Iron Overload – Investigation and Management” (2021) guidelines, serum ferritin levels were categorized into three groups: <300 ng/mL as normal ferritin, 300–600 ng/mL as hyperferritinemia, and >600 ng/mL as iron overload. Result: The mean age of the participants was 45.3±8.3 years. Based on the 2009 JIS criteria for MetS (five components), 38.8% (n=88) had MetS and 61.2% (n=139) were without MetS. According to the British Columbia guidelines, 46.7% (n=106) had normal serum ferritin, 33.9% (n=77) had elevated ferritin, and 19.4% (n=44) had iron overload. When serum iron-related proteins were analyzed by group, the ferritin levels ranged from 33.30 to 1330.00 ng/mL with a mean of 320.34 in the non-MetS group, and from 43.10 to 1044.00 ng/mL with a mean of 378.28 in the MetS group (F=3.957, Sig=0.049), indicating a statistically significant difference in ferritin levels between the two groups. Other iron metabolism indicators, including serum iron, transferrin saturation (TSAT%), Unsaturated iron binding capacity (UIBC), Total iron binding capacity (TIBC), and hepcidin, did not show statistically significant differences between groups. Conclusion Among the indicators of iron metabolism, only serum ferritin levels showed a statistically significant difference between men with and without MetS. Other indicators did not differ significantly, highlighting the need for further detailed investigation.