Objective To investigate the relationship between the serum levels of CXC domain chemokine ligands(CXCLs)and CC domain chemokine ligands(CCLs)and occurrence of pulmonary infection in patients with bronchial asthma and the occurrence of pulmonary infection,as well as their predictive value.Methods A total of 288 patients with bronchial asthma in this hospital from March 2020 to May 2024 were selected as the research subjects.According to whether the patients had secondary pulmonary infection,they were divided into the non-pulmonary infection group(n=217)and the secondary pulmonary infection group(n=71).The differences in general clinical data and the expression profile levels of serum C-reactive protein(CRP),procal-citonin(PCT),CXCLs,and CCLs between the two groups of patients were detected and compared.Univariate and multivariate Logistic regression analyses were used to screen out the risk factors related to secondary pul-monary infection in patients with bronchial asthma,and the efficacy of the combined prediction of each risk factor for secondary pulmonary infection in patients with bronchial asthma was evaluated through the receiver operating characteristic(ROC)curve.Results The age,duration of antibacterial drug use,the proportion of patients applying glucocorticoids,and the proportion of patients receiving mechanical ventilation in the second-ary pulmonary infection group were all significantly longer or higher than those in the non-pulmonary infec-tion group(P＜0.05).The levels of serum CRP,PCT,CXCL5,CXCL10,CXCL13,CCL3,CCL5,CCL19 and CCL21 in the secondary pulmonary infection group were significantly higher than those in the non-pulmonary infection group(P＜0.05).Univariate and multivariate Logistic regression analyses revealed that serum CX-CL5,CXCL10,CXCL13,CCL3,CCL5,CCL19,and CCL21 were all important risk factors for secondary pulmo-nary infection in patients with bronchial asthma(P＜0.05).ROC curve analysis revealed that the independent and combined efficacy of serum CXCL5,CXCL10,CXCL13,CCL3,CCL5,CCL19,and CCL21 levels in predic-ting secondary pulmonary infections in patients with bronchial asthma was relatively high,among which the efficacy of the combined prediction was greater than that of the independent prediction of each index(P＜0.05).Conclusion The expression profile levels of serum CXCLs and CCLs in patients with bronchial asthma are correlated with secondary pulmonary infections.The combined prediction model based on the above indica-tors has a high predictive efficacy for secondary pulmonary infections in patients with bronchial asthma.

Objective:To investigate the prevalence, risk factors and outcomes of diastasis recti abdominis (DRA) in multiparas after the second delivery.Methods:From June 2017 to September 2019, 300 multiparas with an average age of (31.7±4.0) years (26 to 43 years) after the second delivery were recruited at 6 weeks postpartum from two hospitals in Wenzhou. There were 171 multiparas with two natural births,36 multiparas with one natural birth and one caesarean delivery, and 93 multiparas with two caesarean deliveries. The interrectus distance (IRD) was measured with palpation at 6 weeks, 6 months and 12 months after delivery. Data on age, height, weight before pregnancy and delivery, baby′s birth weight, abdominal circumference before pregnancy and delivery, fetus number, delivery mode and occupation type were collected. Strength and endurance of abdominal muscle was assessed using manual muscle testing and curl-ups, low back pain was assessed using Oswestry disability index(ODI), urinary incontinence was assessed with International Consultation on Incontinence guestionnaire-incontinentia urinae (ICIQ-UI) short form (ICIQ-SF), and quality of life was assessed using 36-item short form health survey (SF-36).Results:Prevalence of DRA was 51.7%(155/300), 39.3%(116/295) and 27.7%(80/289) 6 weeks, 6 months and 12 months after delivery, respectively. Logistic regression analysis indicated that age ( OR=1.39, 95 %CI:1.02-1.91, P=0.38), abdominal circumference ratio ( OR=2.31, 95 %CI:1.23-4.33, P=0.01), twins ( OR=11.41, 95 %CI:2.15-60.76, P<0.01), and cesarean section ( OR=1.44, 95 %CI:1.06-1.95, P=0.02) were the risk factors of DRA at 12 months after delivery. At 12 months after delivery, the multiparas with DRA had weaker strength and endurance of abdominal muscle ( Z=-3.62, P<0.01; Z=-8.91, P<0.01), more serious low back pain ( Z=-2.10, P=0.04), and lower quality of life on physical health ( t=-3.34, P<0.01) than the multiparas without DRA. No difference in prevalence and severity of urinary incontinence and quality of life on psychological health was found when comparing multiparas with and without DRA (χ 2=0.66, P=0.42; Z=-1.18, P=0.24; t=0.91, P=0.36). Conclusion:Multipara after the second delivery has great likelihood for DRA.Age, abdominal circumference ratio, twins, and cesarean section are the risk factors of DRA. DRA is related to abdominal muscle dysfunction, low back pain, and quality of life.

Object To study the effects of aerosol inhalation of Compound Salvia Miltiorrhiza Injection (CSMI) on the sputum rheology properties in respiratory tract of postoperative patients after pneumotectomy.Methods Patients in control group inhaled distilled water by ultrasonic nebulizer, patients in the experiment group inhaled CSMI by the same ultrasonic nebulizer.Results The sputum viscosity on the first, third, fourth, and fifth day postoperation (P