BackgroundPatients with depressive disorder often exhibit impaired decision-making functions. However， the relationship between decision-making abilities and depressive and anxiety symptoms in these patients remains unclear. ObjectiveTo explore the characteristics of decision-making behavior in patients with depressive disorder， and to analyze its relationship with clinical symptoms. MethodsA total of 48 patients diagnosed with depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders， fourth edition （DSM-IV） were recruited from the Department of Psychosomatic Medicine of the Affiliated Hospital of Southwest Medical University from October 2020 to May 2023. Concurrently， 52 healthy individuals matched for age and gender were recruited from Luzhou as the control group. Beck Depression Inventory （BDI） and Beck Anxiety Inventory （BAI） were used for assessment， and decision-making behavior was evaluated using Probabilistic Reversal Learning （PRL） task. Indicators assessed included the number of trials to criterion， perseverative errors， win-stay rate and lose-shift rate. Spearman correlation analysis was used to assess the correlation between BDI and BAI scores and PRL task indicators. ResultsThe depression group showed a significantly higher lose-shift rate compared with the control group （t=3.684， P<0.01）. There were no statistically significant differences between two groups in trials to criterion， perseverative errors and win-stay rate （t=0.329， 0.132， 0.609， P>0.05）. In depression group， BDI and BAI scores were positively correlated with the win-stay rate（r=0.450， 0.398， P<0.01）. ConclusionPatients with depressive disorder are more likely to change their decision-making strategies following negative outcomes. Furthermore， the severity of depressive and anxiety symptoms is associated with a greater propensity to maintain existing decisions after receiving positive feedback. ［Funded by 2019 Joint Project of Luzhou Science and Technology Bureau-Southwest Medical University （number， 2019LZXNYDJ39］

BackgroundWith the rapid development of the networking technologies， internet addiction has increasingly become a serious mental health issue. Previous studies have revealed the link between childhood trauma and internet addiction， while the mediating role of perceived stress in this link is not yet clear. ObjectiveTo investigate the role of medical students' perceived stress in the relationship between childhood trauma and internet addiction， so as to provide references for the intervention of internet addiction. MethodsFrom February to March 2023， a random sampling technique was used to select 1 232 undergraduate students from the School of Clinical Medical Sciences of Southwest Medical University as research subjects. The Childhood Trauma Questionnaire-Short Form （CTQ-SF）， Perceived Stress Scale （PSS）， Internet Gaming Disorder Scale （IGDS）， and Bergen Social Media Addiction Scale （BSMAS） were used for assessment. Pearson's correlation coefficients were calculated. The mediation effect of perceived stress in the relationship between childhood trauma and internet addiction was tested using Model 4 in the SPSS Process 4.1， and Bootstrapping procedure involving 5 000 replicates was employed to confirm the statistical significance. ResultsA total of 1 016 （82.47%） valid completed questionnaires were gathered. The CTQ-SF scores of medical students were positively correlated with PSS scores， IGD scores， and BSMAS scores （r=0.583， 0.474， 0.465， P<0.01）. PSS scores were positively correlated with IGD scores and BSMAS scores （r=0.369， 0.479， P<0.01）. Childhood trauma in medical students was found to positively predict perceived stress （β=0.191， P<0.01）， social media addiction （β=0.160， P<0.01）， and internet gaming disorder （β=0.106， P<0.01）. Perceived stress played a significant mediating role in the relationship between childhood trauma and internet gaming disorder， indirect effect value was 0.018 （95% CI： 0.009~0.027）， accounting for 16.98%. Perceived stress also exhibited a significant mediating role in the relationship between childhood trauma and social media addiction， indirect effect value was 0.063 （95% CI： 0.048~0.079）， accounting for 39.38%. ConclusionChildhood trauma in medical students may affect internet gaming disorder and social media addiction through perceived stress. ［Funded by 2022 Annual Research Project of Sichuan Applied Psychology Research Center，（number，CSXL-22102）］

Objective:To investigate the medication law of TCM compound patents for treating primary dilated cardiomyopathy (DCM) based on data mining.Methods:TCM compound patents for the treatment of DCM were retrieved from State Intellectual Property Office of China-Chinese Patent Publication Notice webpage from the establishment of the database to November 18, 2024. After extracting information, statistics were conducted on patent publication time, indications, drug frequency, etc. The association rules of drugs were analyzed using SPSS Modeler 18.0 software based on the Apriori algorithm, and the core drug co-occurrence relationship was visualized using Cytascape 3.9.1 software. SPSS 27.0 software was used to cluster the high-frequency drugs and core co-occurrence drugs. The MCODE plug-in of Cytascape 3.9.1 software was used for graphic clustering analysis.Results:A total of 52 patents were included in this study, with high-frequency syndromes of qi deficiency and blood stasis (16 times), qi and yin deficiency (13 times), blood stasis and water stagnation syndrome (5 times), etc. A total of 236 kinds of Chinese materia medica were involved, with high-frequency herbal medicines such as Astmgali Radix (34 times), Salvia Miltiorrhiza (24 times), Poria (22 times), Ophiopogonis Radix (19 times), etc.; common pairs were Poria → Astmgali Radix (rule support 34.62%, confidence 81.82%), Atractylodes Macrocephala → Poria (rule support 25.0%, confidence 100%), etc.; common medicinal combinations were Atractylodes Macrocephala - Astmgali Radix → Poria (rule support 21.15%, confidence 100%), Astmgali Radix-Schisandrae Chinensis Fructus → Ophiopogonis Radix (rule support 21.15%, confidence 91.67%), etc.; new prescriptions included "Poria, Atractylodes Macrocephala, Ginseng Radix et Rhizoma, Cmnamomi Mmulus, Descurainiae Semen, Aconiti Lateralis Radix Praeparaka, Polyporus", etc.; potential Chinese medicine combinations included "Aconitum Bullatifolium-Eupolyphaga Steleophaga-Myrrh-Os Costaziae-Os Draconis-Olibanum-Moschus-Pyritum", etc.Conclusion:TCM compound patents for treating DCM mainly include qi deficiency and blood stasis, qi-yin deficiency , blood stasis and water stagnation, etc. The basic treatment method is to tonify qi and nourish yin, invigorate blood circulation and eliminate blood stasis, promote water circulation and reduce swelling, and cooperate with the method of softening and dispersing knots.

Objective To explore the medication patterns of Professor Wu Wei,a renowned traditional Chinese medicine(TCM)expert of Guangdong Province,in treating coronary heart disease(CHD)and to provide insights for TCM clinical management of CHD.Methods From September 2015 to September 2024,the prescriptions for effective CHD cases treated by Professor Wu Wei at the Department of Cardiology,the First Affiliated Hospital of Guangzhou University of Chinese Medicine were collected.The prescription data were input into the TCM Inheritance Assistant System(V2.5).Data mining methods of frequency analysis,association rule analysis,association degree analysis,and cluster analysis were employed to analyze the usage frequencies of herbs,association rules among herbs,and potential novel formula combinations.Results A total of 200 prescriptions were included,comprising 134 medicinals.There were 28 herbs used over 15 times.The top 10 most frequently-used herbs were Salviae Miltiorrhizae Radix et Rhizoma,Paeoniae Radix Rubra,Chuanxiong Rhizoma,Dalbergiae Odoriferae Lignum,Ilex Pubescens Radix,Carthami Flos,Scutellariae Radix,Astragali Radix,Fici Simplicissimae Radix,and Bambusae Caulis in Taenia.The commonly-used medicinals can be primarily classified into blood-activating herbs,heat-clearing herbs,qi-tonifying herbs,yin-nourishing herbs,and qi-regulating herbs according to their therapeutic actions.Association rule analysis identified 27 herbal combinations used frequently,predominantly involving Paeoniae Radix Rubra,Salviae Miltiorrhizae Radix et Rhizoma,Dalbergiae Odoriferae Lignum,Chuanxiong Rhizoma,Ilex Pubescens Radix,and Carthami Flos.Association degree analysis revealed that Professor Wu Wei's prescriptions for CHD usually consisted of the combinations of blood-activating,heat-clearing,phlegm-resolving,yin-nourishing,qi-tonifying,qi-regulating,diuretic,and sedative herbs.Complex system entropy-based cluster analysis yielded seven potential novel formulas.Conclusion For the treatment of CHD,Professor Wu Wei focuses on the utilization of heat-clearing and toxin-resolving herbs and blood-activating and stasis-resolving agents,and frequently uses qi-tonifying,phlegm-resolving,qi-regulating,yin-nourishing,diuretic,and sedative herbs as the adjuvant drugs,which reflects his view of CHD's pathogenesis being heat-toxin and blood stasis and his emphasis on the clinical application of heat-clearing and blood-activating therapy.

Objective Based on sentinel symptoms,a nursing intervention program for gastrointestinal symptom group of postoperative chemotherapy for lung cancer was constructed and its application effect was evaluated.Methods The nursing intervention program of gastrointestinal symptom group was constructed on the basis of ref-erence guidelines,qualitative interview and expert consultation.From January 2021 to January 2022,a total of 330 patients with postoperative chemotherapy for lung cancer in a tertiary hospital in Shenyang were selected as re-search subjects.The experimental group received the gastrointestinal symptoms group nursing intervention program on the basis of routine nursing,and the control group received routine care.Patients were investigated with the M.D.Anderson Symptom Inventory and the MOS 36-Item Short-Form Health Survey before 1st chemotherapy(T1),3rd chemotherapy(T2)and 5th chemotherapy(T3).Results After the intervention,the total scores of the 2 groups and the total scores of each symptom in T2 and T3 were statistically significant(P＜0.05),and the score of the experi-mental group was lower than that of the control group.For the scores of 6 dimensions of physiological function,physical pain,overall health,vitality,emotional function,mental health in 2 groups between different time points,the differences are statistically significant(P＜0.05).Conclusion The nursing intervention program of the gastroin-testinal symptom group based on sentinel symptoms is beneficial to reduce the severity of the gastrointestinal symp-tom group and improve the quality of life for postoperative chemotherapy for lung cancer patients.

Objective:To analyze the clinical features of postpartum hepatitis flares in pregnant women with hepatitis B virus (HBV) infection.Methods:A retrospective study was conducted. Patients who met the enrollment criteria were included. Liver function and HBV virology tests were collected from pregnant women with chronic HBV infection at delivery, 6, 24, 36, and 48 weeks after delivery through the hospital information and test system. Additionally, antiviral therapy types and drug withdrawal times were collected. Statistical analysis was performed on all the resulting data.Results:A total of 533 pregnant women who met the inclusion criteria were included, with all patients aged (29.5±3.7) years old. A total of 408 cases received antiviral drugs during pregnancy to interrupt mother-to-child transmission. There was no significant difference in the levels of alanine aminotransferase (ALT, z ?=?-1.981, P ?=?0.048), aspartate aminotransferase (AST, z ?=?-3.956, P ?

The integrated management of multi-campus public hospitals is a mandate for national assessment and compul-sory requirement for high-quality advancement of public hospitals.A challenge in multi-campus hospital management is to accel-erate the standardization of various hospital campuses and facilitate the information sharing among them.Based on the manage-ment practices of multi-campus hospitals in Ningxia,this paper discussed the challenges encountered in the integrated manage-ment of multi-campus hospitals.It proposed strategies to enhance homogeneous management and inter-hospital coordination in multi-hospital and multi-campus hospital to provide valuable references.

Objective To explore the application value of"Internet+Case-based Discussion"in the standardized train-ing of traditional Chinese medicine resident physicians.Methods"Internet+Case-based Discussion"was conducted for 150 resident physicians from three grades who received training in a case hospital.K-means cluster analysis was used to group the e-valuation of resident physicians,and the teaching evaluation of different types of resident physicians was compared.Semantic net-work analysis was used to identify training suggestions and demands of resident physicians.Results There was no statistically significant difference in teaching evaluations among the three grades of resident physicians(P>0.05),and the overall accept-ance was high among resident physicians of different grades.Cluster analysis distinguished the high-scoring group from the medi-um-scoring group,and the difference was statistically significant(P<0.001).Resident physicians in the medium-scoring group believed that teaching teachers lacked close integration of teaching with case discussion and clinical auxiliary result interpretation(P<0.001).Conclusion In the standardized training of traditional Chinese medicine resident physicians,"Internet+Case-based Discussion"can effectively ensure teaching quality and promote the sharing and utilization of teaching resources.

Objective To explore the genetic polymorphism and mutation rate of 36 Y-STR loci in Sichuan Han population and provide basic data for their forensic applications.Methods Blood samples were collected from 307 unrelated male individuals and 367 father-son pairs in Sichuan Han population using FTA blood sampling cards.The Y41SE-v1.2 kit was used to type 36 Y-STR loci,and the population genetic parameters and mutation rates of each locus were calculated.The genetic relationship between Sichuan Han population and other ethnic populations was analyzed in combination with 19 other populations in China.Results A total of 79 mutations were observed in 36 Y-STR loci in 367 father-son pairs of Sichuan Han population,with an average mutation rate of 6.00×10-3.There were 74(93.67%)one-step mutations and 5(6.33%)multi-step mutations.A total of 383 alleles were found at 36 Y-STR loci in 307 Sichuan Han males.The number of alleles at each locus ranged from 5(0.016 29)to 56(0.182 41),GD ranged from 0.100 02(DYS645)to 0.959 99(DYS385),and 306 haplotypes were found.The HD,DC and HMP values were 0.999 973,99.67%and 0.003 284,respectively.The results of genetic distance(Fst)analysis showed that the Sichuan Han population had the closest genetic distance with the Chongqing Han population(0.000 9)and the furthest genetic distance with the Xinjiang Mongolian group(0.032 0).The MDS based on genetic distance was basically consistent with the results of cluster analysis.Conclusion The 36 Y-STR loci have high genetic polymorphism in the Sichuan Han population.The study data can provide data support for the construction of the Y-STR database in this region,and also provide basic genetic information for forensic investigation and population genetics research.

Objective:To explore the chain mediating effect of anxiety and flow experience on perceived stress and mobile phone addiction in nursing college students.Methods:In December 2021, a cross-sectional design survey was conducted on 4 179 freshmen and sophomores in a nursing college in Heilongjiang Province. The Chinese perceived stress scale, generalized anxiety disorder-7, flow state scale, and mobile phone addiction tendency scale were selected separately to assess perceived stress, anxiety symptoms, flow experience and mobile phone addiction. SPSS 26.0 software was used for descriptive analysis, independent sample t-test, Spearman correlation analysis, and AMOS 24.0 software was used for mediating effect test. Results:(1) Among the 3 050 nursing students, there were 714(23.41%) students who were addicted to mobile phones. (2) Spearman correlation analysis indicated that perceived stress(27.31±9.56) was positively correlated with anxiety(7.00(1.00, 10.00), r=0.441, P<0.05), flow experience((12.00±3.40), r=0.517, P<0.05), and mobile phone addiction((42.42±13.05), r=0.476, P<0.05).Anxiety was positively correlated with flow experience ( r=0.430, P<0.01) and mobile phone addiction ( r=0.538, P<0.01).Flow experience was positively correlated with mobile phone addiction ( r=0.490, P<0.01). (3) Anxiety and flow experience played seperate mediating and chain mediating roles between perceived stress and mobile phone addiction, accounting for 26.06%(0.165/0.633), 23.54%(0.149/0.633) and 3.48%(0.022/0.633) of the total effect. Conclusion:Perceived stress not only directly affects the mobile phone addiction of nursing students, but also indirectly affects mobile phone addiction through the independent and chain mediating effects of anxiety and flow experience.