Objective:To investigate the clinical characteristics,and diagnostic and curative performance of patients with peptic ulcer disease(PUD)in Lhasa region.Methods:A retrospective analysis was conducted on 237 PUD patients who received diagnosis and treatment at Lhasa People's Hospital between September 2017 and December 2019.The general information of demographics,clinical presentations,treatment and outcomes of patients were investigated and analyzed.Results:In the PUD patients of this region,180 cases were male patients(75.9%),which was more than 57 female patients(24.1%),and 89 cases(37.6%)had smoking history with long term and 70 cases(29.5%)had history of heavy drinking.In the common comorbidities,39 cases(16.5%)were chronic liver disease,24 cases(10.1%)were hypertension,and 8 cases(3.4%)were arthritis(gout).Clinical symptoms presented in 234 PUD patients(98.7%),and the most common symptoms were respectively abdominal pain(200 cases,84.4%),hematemesis or melena(122 cases,51.5%),heartburn(90 cases,38.0%),and abdominal distension(84 cases,35.4%).The number of patients with multiple ulcers was 131 cases(55.3%),which was more than that of patients with single ulcers(106 cases,44.7%).The distribution of ulcer locations,from most to least frequent,was as follows:gastric angle(124 cases,52.3%),gastric body(72 cases,30.4%),antrum(69 cases,29.1%),pylorus(48 cases,20.3%),duodenal bulb(29 cases,12.2%)and gastric fundus(14 cases,5.9%).In the 235 patients whose treatment plans could be tracked,229 cases(97.4%)received standard acid-suppressive therapy and gastric mucosal protectant.In the 237 PUD patients,166 cases received follow-up,and 161 PUD patients provided feedbacks for symptom.The result showed that the symptoms of 158(98.1%)patients were alleviated or disappeared.In the 166 patients who received follow-up,49 cases underwent reexamination of endoscopy,and 11 cases(22.4%)of them appeared recurrence of ulcer.During the period of study,7 patients(4.2%)of 166 patients who received follow-up re-admitted to hospital due to PUD,and 7 patients(4.2%)died,and the main reasons of death involved to gastrointestinal bleeding,gastric cancer,stomach-related diseases,liver cancer,and coronary heart disease.Conclusion:The result of this study provided important information of clinical characteristics of PUD in the Lhasa region.The prognostic research of that is helpful to better understand the epidemiological characteristics and the status of clinical management for PUD in this region.However,this study still need larger sample size and further research to confirm and expand these results.

Objective To compare and analyze the visual outcome and safety of phacoemulsification with small incision non-phacoemulsification for cataract and provide a reference for the selection of surgery methods in Tibet.Methods A prospective cohort study was performed.Eighty eyes of 80 consecutive patients with age-related cataract were included in Titet Autonomous Region Tibetan Tradition Medicine Hospital from July to August 2016.The eyes were assigned to non-phacoemulsification extracapsular cataract extraction with small incision combined with intraocular lens (IOL) implantation group (small incision group) and phacoemulsification extracapsular cataract extraction combined with IOL implantation group (phacoemulsification group),with 40 eyes for each group.The uncorrected visual outcome and complications were compared between the two groups after surgery.Results There were no significant differences in gender,age,preoperative visual acuity,and lens nuclear hardness between the two groups (all at P＞0.05).The eyes in various post-operative uncorrected visual acuity outcome was not significantly different 1 day and 5 days after surgery between the two groups (both at P＞0.05).In the fifth day after surgery,the eye number in various post-operative uncorrected visual acuity outcome was not significantly different in the eyes with grade Ⅱ and Ⅲ nuclei between the two groups (Z =0.503,P =0.478;Z =0.952,P =0.329).The eye number of acuity ≥0.5 in the small incision group was significantly more than that in the phacoemulsification group in the eyes with grade Ⅳ nuclei (Z =4.501,P =0.034).The eye number with post-operative transiently ocular hypertension was increased in small incision group compared with phacoemulsification group.Conclusions Non-phacoemulsification surgery with small incision has comparable visual outcome with phacoemulsification surgery,and small incision nonphacoemulsification surgery combined with IOL implantation can serve as the preferred surgical method in basic level medical institutions of Tibet.